{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:59:26Z","timestamp":1790171966545,"version":"4.1.0"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sagliker syndrome (SS), commonly referred to as \u201cUglifying human face Syndrome,\u201d is a rare but serious outcome of chronic kidney disease characterized by skeletal deformities, especially in the skull and jaws, due to uncontrolled secondary hyperparathyroidism (SHPT). The diagnosis is made through a combination of clinical symptoms, radiographic evidence (demonstrating bone deformities), and laboratory evaluations. Timely and effective treatment of SHPT is essential to prevent or lessen the onset of SS. Treatment includes managing phosphorus levels (through dietary changes, phosphate binders, and dialysis), correcting Vitamin D deficiency, and performing parathyroid surgery. A 23-year-old male from a semi-urban area came to our department with huge facial deformity. Following the hematological test, we discovered markedly elevated levels of parathyroid hormone, elevated alkaline phosphatase, and markedly elevated levels of urea and creatinine. In addition, the serum calcium level was also increased. The patient was referred to a higher center for consultation regarding endocrinal evaluation and further treatment plans.<\/jats:p>","DOI":"10.4103\/ccd.ccd_241_26","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:01:21Z","timestamp":1790078481000},"page":"226-229","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Sagliker Syndrome: A Diagnostic Challenge"],"prefix":"10.4103","volume":"17","author":[{"given":"Arani","family":"Datta","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Gurunanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SK. Abdul","family":"Mahmud","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Gurunanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudra Prasad","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Gurunanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeshna","family":"Bagchi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Gurunanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehebuba","family":"Sultana","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Gurunanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunit","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Gurunanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mousumi","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Microbiology, Gurunanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"R1-20260923","first-page":"488","article-title":"Leontiasis ossea, slipped epiphyses, and granulosa cell tumor of testis with renal disease; report of a case with autopsy findings","volume":"56","author":"Cohen","year":"1953","journal-title":"AMA Arch Pathol"},{"key":"R2-20260923","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.semnephrol.2004.06.021","article-title":"Sagliker syndrome: Uglifying human face appearance in late and severe secondary hyperparathyroidism in chronic renal failure","volume":"24","author":"Sagliker","year":"2004","journal-title":"Semin Nephrol"},{"key":"R3-20260923","doi-asserted-by":"crossref","first-page":"176","DOI":"10.18203\/2349-3259.ijct20251214","article-title":"The face of Sagliker's syndrome in maxillofacial aspect: A brief review","volume":"12","author":"Bansod","year":"2025","journal-title":"Int J Clin Trials"},{"key":"R4-20260923","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1053\/j.jrn.2007.10.023","article-title":"International study on Sagliker syndrome and uglifying human face appearance in severe and late secondary hyperparathyroidism in chronic kidney disease patients","volume":"18","author":"Sagliker","year":"2008","journal-title":"J Ren Nutr"},{"key":"R5-20260923","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1053\/j.jrn.2011.10.030","article-title":"International evaluation of unrecognizably uglifying human faces in late and severe secondary hyperparathyroidism in chronic kidney disease (Sagliker syndrome): A unique catastrophic entity with cytogenetic studies and GNAS1 mutations","volume":"22","author":"Yildiz","year":"2012","journal-title":"J Ren Nutr"},{"key":"R6-20260923","first-page":"e51956","article-title":"Sagliker syndrome in a patient with secondary hyperparathyroidism and chronic kidney disease: A case report from Palestine","volume":"16","author":"Ahmad","year":"2024","journal-title":"Cureus"},{"key":"R7-20260923","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1053\/j.jrn.2010.06.002","article-title":"Audiological findings in chronic kidney disease patients with Sagliker syndrome","volume":"20","author":"Erkan","year":"2010","journal-title":"J Ren Nutr"},{"key":"R8-20260923","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1053\/j.jrn.2006.04.018","article-title":"Neurologic manifestations in Sagliker syndrome: Uglifying human face appearance in severe and late secondary hyperparathyroidism in chronic renal failure patients","volume":"16","author":"Giray","year":"2006","journal-title":"J Ren Nutr"},{"key":"R9-20260923","first-page":"e64399","article-title":"Sagliker syndrome: A case report of facial deformities and renal osteodystrophy secondary to hyperparathyroidism in end-stage renal disease","volume":"16","author":"Garc\u00eda Romero","year":"2024","journal-title":"Cureus"},{"key":"R10-20260923","article-title":"An Unprecedented Association; Coronary Artery Disease and Sagliker Syndrome","author":"Y\u0131lmaz","journal-title":"International Journal of the Cardiovascular Academy"},{"key":"R11-20260923","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4274\/mirt.galenos.2023.24382","article-title":"Bone and parathyroid scintigraphy findings in Sagliker syndrome","volume":"33","author":"Erol","year":"2024","journal-title":"Mol Imaging Radionucl Ther"},{"key":"R12-20260923","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/08998280.2019.1624092","article-title":"Sagliker syndrome in a patient with end-stage renal disease with secondary hyperparathyroidism","volume":"32","author":"Panezai","year":"2019","journal-title":"Baylor Univ Med Cent Proc"},{"key":"R13-20260923","first-page":"e101753","article-title":"Severe manifestation of hyperparathyroidism with Sagliker syndrome: A case report","volume":"18","author":"Morantes Salazar","year":"2026","journal-title":"Cureus"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_241_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:01:20Z","timestamp":1790168480000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_241_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ccd.ccd_241_26","relation":{},"ISSN":["0976-237X","0976-2361"],"issn-type":[{"value":"0976-237X","type":"print"},{"value":"0976-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-04-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}