{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:37:42Z","timestamp":1787071062339,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:p>Regenerative endodontic treatment (RET) promotes tissue regeneration and root development in immature necrotic teeth. This case series examines RET outcomes in varied cases, including immature and mature teeth with periapical pathology, failed root canal treatments, large cyst-like lesions, and internal inflammatory root resorption. Five cases were treated using standardized RET protocols, including sodium hypochlorite and ethylenediaminetetraacetic acid irrigation, intracanal medicaments, and biological scaffolds (blood clot, platelet-rich plasma, and platelet-rich fibrin). Canals were sealed with biocompatible materials, followed by clinical and radiographic monitoring. All patients remained asymptomatic, with radiographic evidence of periapical healing. Some teeth showed canal narrowing due to calcific tissue deposition. Despite the absence of pulp sensibility responses, all cases demonstrated successful healing. RET is a promising, versatile approach for managing complex endodontic conditions. Success depends on effective disinfection, scaffold selection, and individualized planning. Continued research and protocol refinement are essential for broader clinical application.<\/jats:p>","DOI":"10.4103\/ccd.ccd_269_25","type":"journal-article","created":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:00:15Z","timestamp":1761984015000},"page":"207-213","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A Case Series on Regenerative Endodontic Treatment: Clinical Applications and Outcomes"],"prefix":"10.4103","volume":"16","author":[{"given":"Swati","family":"Markandey","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haridas Das","family":"Adhikari","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Dr. R. Ahmed Dental College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,31]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.joen.2015.07.004","article-title":"Management of teeth with persistent apical periodontitis after root canal treatment using regenerative endodontic therapy","volume":"41","author":"Saoud","year":"2015","journal-title":"J Endod"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s00784-021-04123-z","article-title":"Management of internal inflammatory root resorption using injectable platelet-rich fibrin revascularization technique: A clinical study with cone-beam computed tomography evaluation","volume":"26","author":"Nageh","year":"2022","journal-title":"Clin Oral Investig"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.joen.2014.07.027","article-title":"Treatment of a large cystlike inflammatory periapical lesion associated with mature necrotic teeth using regenerative endodontic therapy","volume":"40","author":"Saoud","year":"2014","journal-title":"J Endod"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"e37","DOI":"10.1016\/j.tripleo.2005.07.008","article-title":"Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution","volume":"101","author":"Dohan","year":"2006","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/scrt218","article-title":"Platelet-rich plasma preparation for regenerative medicine: Optimization and quantification of cytokines and growth factors","volume":"4","author":"Amable","year":"2013","journal-title":"Stem Cell Res Ther"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.joen.2012.06.018","article-title":"Direct effect of intracanal medicaments on survival of stem cells of the apical papilla","volume":"38","author":"Ruparel","year":"2012","journal-title":"J Endod"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1600-9657.1995.tb00473.x","article-title":"Short versus long-term calcium hydroxide treatment of established inflammatory root resorption in replanted dog teeth","volume":"11","author":"Trope","year":"1995","journal-title":"Endod Dent Traumatol"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"530","DOI":"10.4103\/jcd.jcd_535_21","article-title":"Treatment outcome of regenerative endodontic procedures in mature permanent teeth compared to nonsurgical endodontic treatment: A systematic review and meta-analysis","volume":"24","author":"Nangia","year":"2021","journal-title":"J Conserv Dent"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.tripleo.2004.05.002","article-title":"Cytotoxicity evaluation of gutta-percha solvents: Chloroform and GP-solvent (limonene)","volume":"98","author":"Vajrabhaya","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12903-024-04064-5","article-title":"Does the use of different scaffolds have an impact on the therapeutic efficacy of regenerative endodontic procedures? A systematic evaluation and meta-analysis","volume":"24","author":"Yang","year":"2024","journal-title":"BMC Oral Health"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"e12195","DOI":"10.1111\/jicd.12195","article-title":"Calcium silicate-based cements: Composition, properties, and clinical applications","volume":"8","author":"Dawood","year":"2017","journal-title":"J Investig Clin Dent"},{"key":"R14-20260420","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/j.joen.2017.06.018","article-title":"Revascularization-associated intracanal calcification: Assessment of prevalence and contributing factors","volume":"43","author":"Song","year":"2017","journal-title":"J Endod"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_269_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:40:56Z","timestamp":1787067656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_269_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/ccd.ccd_269_25","relation":{},"ISSN":["0976-237X","0976-2361"],"issn-type":[{"value":"0976-237X","type":"print"},{"value":"0976-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2025-06-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}