{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:27:55Z","timestamp":1786649275197,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Electrical impedance spectroscopy (EIS) has recently developed as a novel diagnostic device for screening and evaluating cervical dysplasia, prostate cancer, breast cancer, and basal cell carcinoma. The current study aimed to validate and evaluate bioimpedance as a diagnostic tool for tobacco-induced oral lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>\n                      The study comprised 50 oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs) tissue specimens for\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      study and 320 subjects for\n                      <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                      study. Bioimpedance device prepared and calibrated. EIS measurements were done for the habit and control groups and were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The impedance value in the control group was significantly higher compared to the OPMD and OSCC groups. Diagnosis based on bioimpedance spectroscopy measurements has a sensitivity of 95.9% and a specificity of 86.7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Bioimpedance device can help in decision-making for differentiating OPMD and OSCC cases and their management, especially in primary healthcare settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_290_24","type":"journal-article","created":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T17:00:13Z","timestamp":1752512413000},"page":"104-110","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Bioimpedance a Diagnostic Tool for Tobacco-induced Oral Lesions \u2013 A Mixed Model Cross-sectional 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