{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:21Z","timestamp":1787841321316,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Oral lichen planus (OLP) is a chronic autoimmune condition requiring prompt treatment to alleviate the signs and symptoms. There is weak evidence emphasizing the efficacy of any one therapy. Steroids, of all the therapies, have proved to be effective and hence considered as the standard care for OLP. However, the complications associated with it further worsen the patient's condition. Alternative safe approaches such as herbal interventions (HIs) have been tried in OLP. Their efficacies could only be evaluated from properly designed research protocols such as randomized controlled trials (RCTs). The present systematic review aims to assess the efficacy of HIs compared to steroids in RCTs involving OLP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>An extensive search for HIs in OLP was conducted in PubMed, MEDLINE, Cochrane Central Register of Controlled Trials, Scopus, and gray literature. Eight studies fulfilled the eligibility criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In all the studies, clinical severity was significantly reduced in within-group comparisons, whereas between-group comparisons showed nonsignificant results, except for total glucosides of paeony capsules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Efficacy of herbal therapy in OLP should be weighed against the high bias in the studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_320_20","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T02:48:38Z","timestamp":1608432518000},"page":"311-319","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of Herbal Interventions in Oral Lichen Planus: A Systematic Review"],"prefix":"10.4103","volume":"11","author":[{"given":"Ashita R.","family":"Kalaskar","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology, Government Dental College and Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul R.","family":"Bhowate","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, DMIMS (DU), Sawangi (Meghe), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritesh R.","family":"Kalaskar","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Government Dental College and Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheelpriya R.","family":"Walde","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance, Gurunanak College of Pharmacy, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana D.","family":"Ramteke","sequence":"additional","affiliation":[{"name":"Department of Kaumar Hritya, Shri Ayurvedic College and Hospital, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka P.","family":"Banode","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sharad Pawar Dental College, DMIMS DU, Sawangi (Meghe), Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,12,20]]},"reference":[{"key":"R1-20250920","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/154411130201300405","article-title":"The pathogenesis of oral lichen planus","volume":"13","author":"Sugerman","year":"2002","journal-title":"Crit Rev Oral Biol Med"},{"key":"R2-20250920","first-page":"26","article-title":"Oral lichen planus.Update for the general practitioner","volume":"69","author":"Stoopler","year":"2003","journal-title":"N Y State Dent J"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1054\/bjom.2000.0335","article-title":"Oral lichen planus: A review","volume":"38","author":"Mollaoglu","year":"2000","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R4-20250920","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0733-8635(02)00067-0","article-title":"The clinical manifestations and treatment of oral lichen planus","volume":"21","author":"Eisen","year":"2003","journal-title":"Dermatol Clin"},{"key":"R5-20250920","first-page":"494","article-title":"Oral lichen planus: Clinical presentation and management","volume":"68","author":"Edwards","year":"2002","journal-title":"J Can Dent Assoc"},{"key":"R6-20250920","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1177\/10454411980090010501","article-title":"Update on oral lichen planus: Etiopathogenesis and management","volume":"9","author":"Scully","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1600-0714.2010.00946.x","article-title":"Pathogenesis of oral lichen planus--a review","volume":"39","author":"Roopashree","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"R8-20250920","first-page":"80","article-title":"Topical Corticosteroids in Oral Pathology.Vol 16","author":"Krasteva","year":"2010","journal-title":"Journal of IMAB-Annual Proceeding (Scientific Paper)"},{"key":"R9-20250920","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2334\/josnusd.50.377","article-title":"Steroids in the treatment of lichen planus: A review","volume":"50","author":"Thingprasom","year":"2008","journal-title":"J Oral Sci"},{"key":"R10-20250920","doi-asserted-by":"crossref","first-page":"460","DOI":"10.4103\/0019-5154.139874","article-title":"Systemic side-effects of topical corticosteroids","volume":"59","author":"Dhar","year":"2014","journal-title":"Indian J Dermatol"},{"key":"R11-20250920","first-page":"198","volume":"4","author":"Singh","year":"2013","journal-title":"Turmeric a new treatment option for lichen planus: A pilot study Natl J Maxillofac Surg"},{"key":"R12-20250920","first-page":"503","article-title":"A self-controlled single blinded clinical trial to evaluate oral lichen planus after topical treatment with Aloe vera","volume":"21","author":"Kareman","year":"2013","journal-title":"J GHR"},{"key":"R13-20250920","doi-asserted-by":"crossref","first-page":"222","DOI":"10.4103\/0019-5154.156315","article-title":"Oral lichen planus: An update on etiology, pathogenesis, clinical presentation, diagnosis and management","volume":"60","author":"Gupta","year":"2015","journal-title":"Indian J Dermatol"},{"key":"R14-20250920","first-page":"CD001168","article-title":"Interventions for treating oral lichen planus","volume":"7","author":"Thongprasom","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"R15-20250920","first-page":"CD008092","article-title":"Interventions for erosive lichen planus affecting mucosal sites","volume":"2","author":"Cheng","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"R16-20250920","doi-asserted-by":"crossref","first-page":"377","DOI":"10.2334\/josnusd.50.377","article-title":"Steroids in the treatment of lichen: A review","volume":"50","author":"Thongprasom","year":"2008","journal-title":"J Oral Sci"},{"key":"R18-20250920","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/MAJ.0b013e3182171164","article-title":"Comparison of Aloe vera mouthwash with triamcinolone acetonide 0.1% on oral lichen planus: A randomized double-blinded clinical trial","volume":"342","author":"Mansourian","year":"2011","journal-title":"Am J Med Sci"},{"key":"R19-20250920","first-page":"151","article-title":"Effect of cedar honey in the treatment of oral lichen planus","volume":"26","author":"Sanatkhani","year":"2014","journal-title":"Iran J Otorhinolaryngol"},{"key":"R20-20250920","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15171\/joddd.2015.005","article-title":"A randomized placebo-controlled double blind clinical trial of quercetin for treatment of oral lichen planus","volume":"9","author":"Amirchaghmaghi","year":"2015","journal-title":"J Dent Res Dent Clin Dent Prospect"},{"key":"R21-20250920","first-page":"789","article-title":"Comparative efficacy of topical curcumin and triamcinilone for oral lichen planus: A Randomized, controlled clinical trial","volume":"12","author":"Kia","year":"2015","journal-title":"J Dent Tehran Univ Med Sci"},{"key":"R22-20250920","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.intimp.2016.03.035","article-title":"Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids","volume":"36","author":"Zhou","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"R23-20250920","first-page":"134","article-title":"Evaluation of the Efficacy of curcumin in the treatment of oral lichen planus: A randomized controlled trial","volume":"10","author":"Amirchaghmaghi","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"R24-20250920","first-page":"89","article-title":"Evaluation of efficacy of 1% curcuminoids as local application in management of oral lichen planus interventional study","volume":"11","author":"Thomas","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"R25-20250920","first-page":"658","article-title":"Evaluation of the efficacy of lycopene in the management of oral lichen planus: A pilot randomized clinical trial","volume":"75","author":"Arbabi-Kalati","year":"2017","journal-title":"Tehran Univ Med J"},{"key":"R26-20250920","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1600-0714.2009.00830.x","article-title":"Topical tacrolimus and pimecrolimus in the treatment of oral lichen planus: An update","volume":"39","author":"Lopez-Jornet","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"R27-20250920","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1468-3083.2010.03583.x","article-title":"Efficacy of sulfasalazine in the treatment of generalized lichen planus: Randomized double-blinded clinical trial on 52 patients","volume":"24","author":"Omidian","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R28-20250920","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0304-3835(95)03827-J","article-title":"Anti-tumour and antioxidant activity of natural curcuminoids","volume":"94","author":"Ruby","year":"1995","journal-title":"Cancer Lett"},{"key":"R29-20250920","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4103\/0976-9668.107253","article-title":"Role of curcumin in systemic and oral health: An overview","volume":"4","author":"Nagpal","year":"2013","journal-title":"J Nat Sci Biol Med"},{"key":"R30-20250920","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1021\/jf101077s","article-title":"Antioxidant\/lipoxygenase inhibitory activities and chemical compositions of selected essential oils","volume":"58","author":"Wei","year":"2010","journal-title":"J Agric Food Chem"},{"key":"R31-20250920","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.clindermatol.2009.05.015","article-title":"Cosmeceuticals and natural products: Wound healing","volume":"27","author":"Davis","year":"2009","journal-title":"Clin Dermatol"},{"key":"R32-20250920","first-page":"CD001168","article-title":"Interventions for treating oral lichen planus","volume":"7","author":"Thongprasom","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"R33-20250920","first-page":"ZE10","article-title":"medical management of oral lichen planus: A systematic review","volume":"10","author":"Singh","year":"2016","journal-title":"J Clin Diagn Res"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_320_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:48:36Z","timestamp":1787838516000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_320_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/ccd.ccd_320_20","relation":{},"ISSN":["0976-237X","0976-2361"],"issn-type":[{"value":"0976-237X","type":"print"},{"value":"0976-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"2020-04-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}