{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:43:46Z","timestamp":1786725826790,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim:<\/jats:title>\n                    <jats:p>Oxidative stress markers have been firmly established as elevated in oral squamous cell carcinomas (OSCCs). These markers play a crucial role in the pathogenic mechanism underlying the accumulation of advanced glycation end products (AGEs) and their respective receptors. The primary objective of this study is to discern and compare the levels of receptors of AGEs (RAGEs) within tissue samples from patients diagnosed with oral submucous fibrosis (OSMF) at varying stages, oral leukoplakia at various stages, and OSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A cross-sectional investigation was conducted, enrolling a total of 49 patients, distributed across three distinct groups. Tissue samples were meticulously collected from the aforementioned patient groups. Subsequently, these samples underwent a process of homogenization and centrifugation. The supernatant obtained was subjected to enzyme-linked immunosorbent assay analysis to precisely determine the concentration of RAGE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The concentration of RAGEs was found to be significantly higher at various stages of OSMF when compared to the reference group of OSCC (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). This difference was statistically significant, indicating a substantial association. In contrast, the levels of RAGE in patients with hyperkeratosis accompanied by epithelial dysplasia at various stages were observed to be lower than those in the OSCC group, with the difference in concentration being statistically insignificant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This comprehensive study has provided compelling evidence demonstrating the heightened levels of RAGE in OSMF when compared to OSCC. These findings collectively suggest the potential utility of anti-RAGE interventions as a promising avenue for novel therapeutic strategies in potentially malignant disorders such as OSMF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_427_23","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T15:42:27Z","timestamp":1720539747000},"page":"71-76","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Quantitative Assessment of Receptors of Advanced Glycation End Products Expression in Tissue Samples from Patients with oral Submucous Fibrosis, Leukoplakia, and Oral Squamous Cell Carcinoma"],"prefix":"10.4103","volume":"15","author":[{"given":"Palati","family":"Sinduja","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratibha","family":"Ramani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saravanan","family":"Sekaran","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"R1-20260507","doi-asserted-by":"crossref","first-page":"271","DOI":"10.4054\/DemRes.2002.7.5","article-title":"The cancer transition in Japan since 1951","volume":"7","author":"Gersten","year":"2002","journal-title":"Demogr Res"},{"key":"R2-20260507","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/j.1468-0009.2005.00398.x","article-title":"The epidemiologic transition: A theory of the epidemiology of population change. 1971","volume":"83","author":"Omran","year":"2005","journal-title":"Milbank Q"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"1","DOI":"10.47203\/IJCH.2019.v31i01.001","article-title":"Cancer scenario in India and its comparison with rest of the world and future perspectives","volume":"31","author":"Kishore","year":"2019","journal-title":"Indian J Comm Health"},{"key":"R5-20260507","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1875-595x.2012.00131.x","article-title":"Oral cancer in India continues in epidemic proportions: Evidence base and policy initiatives","volume":"63","author":"Gupta","year":"2013","journal-title":"Int Dent J"},{"key":"R6-20260507","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/jomfp.JOMFP_113_17","article-title":"Oral cancer statistics in India on the basis of first report of 29 population-based cancer registries","volume":"22","author":"Sharma","year":"2018","journal-title":"J Oral Maxillofac Pathol"},{"key":"R7-20260507","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.oooo.2017.12.011","article-title":"Oral potentially malignant disorders: Risk of progression to malignancy","volume":"125","author":"Speight","year":"2018","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"R8-20260507","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/j.1600-0714.2007.00584.x","article-title":"Oral epithelial dysplasia classification systems: Predictive value, utility, weaknesses and scope for improvement","volume":"37","author":"Warnakulasuriya","year":"2008","journal-title":"J Oral Pathol Med"},{"key":"R9-20260507","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/1097-0142(19840201)53:3<563::AID-CNCR2820530332>3.0.CO;2-F","article-title":"Oral leukoplakia and malignant transformation. 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