{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:42:45Z","timestamp":1787071365626,"version":"build-2736575974"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Odontogenic myxoma (OM) is a rare benign tumor of mesenchymal origin, representing 3%\u20136% of odontogenic tumors and more commonly affecting the mandible. Histologically, it consists of stellate and spindle-shaped cells within a myxoid stroma, with fibromyxoma considered a collagen-rich variant. Most OMs are intraosseous, showing slow growth but infiltrative behavior, with recurrence rates of up to 43% following incomplete excision. Peripheral OMs (POMs), in contrast, are exceptionally uncommon extraosseous lesions arising in gingival or perigingival tissues. Although less aggressive, their clinical presentation is often nonspecific, mimicking other benign or malignant conditions, which complicates diagnosis. Treatment ranges from conservative enucleation to wide surgical resection depending on size and aggressiveness, with long-term follow-up being crucial. This article reports two surgically treated cases: one peripheral lesion with fibromyxoid features and one central intraosseous form, highlighting diagnostic considerations, management strategies, and current literature perspectives.<\/jats:p>","DOI":"10.4103\/ccd.ccd_518_25","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T05:00:11Z","timestamp":1774587611000},"page":"58-61","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Myxoma Unveiled: Insights from Central and Peripheral Variants through Two Rare Cases"],"prefix":"10.4103","volume":"17","author":[{"given":"Akram","family":"Belmehdi","sequence":"first","affiliation":[{"name":"D\u00e9partement de Chirurgie Orale, Facult\u00e9 de M\u00e9decine Dentaire de Rabat, Universit\u00e9 Mohammed V de Rabat, Maroc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Cherradi","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'anatomie Pathologique, Universit\u00e9 Mohammed V de Rabat, H\u00f4pital des Sp\u00e9cialit\u00e9s, H\u00f4pital Universitaire Ibn Sina de Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafsa El","family":"Ouazzani","sequence":"additional","affiliation":[{"name":"D\u00e9partement d'anatomie Pathologique, Universit\u00e9 Mohammed V de Rabat, H\u00f4pital des Sp\u00e9cialit\u00e9s, H\u00f4pital Universitaire Ibn Sina de Rabat, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloua","family":"Dghoughi","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Chirurgie Orale, Facult\u00e9 de M\u00e9decine Dentaire de Rabat, Universit\u00e9 Mohammed V de Rabat, Maroc"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,26]]},"reference":[{"key":"R2-20260420","first-page":"168","article-title":"The world health organization classification of odontogenic lesions: A summary of the changes of the 2022 (5th) Edition","volume":"38","author":"Soluk-Tekkesin","year":"2022","journal-title":"Turk Patoloji Derg"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"e39158","DOI":"10.1016\/j.heliyon.2024.e39158","article-title":"Odontogenic myxoma: A clinicopathological study over 15 years and immunohistochemical analysis","volume":"10","author":"Juengsomjit","year":"2024","journal-title":"Heliyon"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4317\/medoral.19842","article-title":"Odontogenic myxofibroma: A concise review of the literature with emphasis on the surgical approach","volume":"20","author":"Meleti","year":"2015","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.bjoms.2019.09.005","article-title":"Recurrence rate of odontogenic myxoma after different treatments: A systematic review","volume":"57","author":"Saalim","year":"2019","journal-title":"Br J Oral Maxillofac Surg"},{"key":"R6-20260420","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.2174\/1874210601812011079","article-title":"Peripheral odontogenic myxoma: Report of two new cases with a critical review of the literature","volume":"12","author":"Mascitti","year":"2019","journal-title":"Open Dent J"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"100078","DOI":"10.1016\/j.adoms.2021.100078","article-title":"Peripheral odontogenic myxoma; a rare case report with an extensive literature review","volume":"3","author":"Tatsis","year":"2021","journal-title":"Adv Oral Maxillofac Surg"},{"key":"R8-20260420","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4103\/0970-9290.191896","article-title":"Peripheral odontogenic myxoma","volume":"27","author":"Tasnime","year":"2016","journal-title":"Indian J Dent Res"},{"key":"R9-20260420","doi-asserted-by":"crossref","first-page":"178","DOI":"10.5125\/jkaoms.2017.43.3.178","article-title":"Peripheral odontogenic myxoma in a 12-year-old girl: A rare entity","volume":"43","author":"Kanitkar","year":"2017","journal-title":"J Korean Assoc Oral Maxillofac Surg"},{"key":"R10-20260420","doi-asserted-by":"crossref","first-page":"e637","DOI":"10.4317\/jced.58080","article-title":"Odontogenic myxoma: Follow-Up of 13 cases after conservative surgical treatment and review of the literature","volume":"13","author":"Martins","year":"2021","journal-title":"J Clin Exp Dent"},{"key":"R11-20260420","doi-asserted-by":"crossref","first-page":"e13214","DOI":"10.1111\/eci.13214","article-title":"Odontogenic myxoma: Systematic review and bias analysis","volume":"50","author":"Dotta","year":"2020","journal-title":"Eur J Clin Invest"},{"key":"R12-20260420","doi-asserted-by":"crossref","first-page":"1093412","DOI":"10.1155\/2021\/1093412","article-title":"Central odontogenic myxoma: A radiographic analysis","volume":"2021","author":"Ghazali","year":"2021","journal-title":"Int J Dent"},{"key":"R13-20260420","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4103\/0970-9290.38934","article-title":"Odontogenic myxoma of maxilla","volume":"19","author":"Sivakumar","year":"2008","journal-title":"Indian J Dent Res"},{"key":"R14-20260420","doi-asserted-by":"crossref","first-page":"3","DOI":"10.9790\/0853-0120305","article-title":"The histological spectrum of myxoma, myxofibroma\/fibromyxoma and odontogenic fibroma: \u201ca chicken and egg situation\u201d","volume":"1","author":"Mehendiratta","year":"2012","journal-title":"IOSR J Dent Med Sci"},{"key":"R15-20260420","doi-asserted-by":"crossref","first-page":"20160232","DOI":"10.1259\/dmfr.20160232","article-title":"Characteristic features of the odontogenic myxoma on cone beam computed tomography","volume":"46","author":"Wang","year":"2017","journal-title":"Dentomaxillofac Radiol"},{"key":"R16-20260420","first-page":"112","article-title":"Peripheral odontogenic myxoma of Zygoma and orbital region \u2013 A unique case report with review of literature","volume":"14","author":"Nikunj","year":"2024","journal-title":"Ann Maxillofac Surg"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_518_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:44:59Z","timestamp":1787067899000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_518_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ccd.ccd_518_25","relation":{},"ISSN":["0976-237X","0976-2361"],"issn-type":[{"value":"0976-237X","type":"print"},{"value":"0976-2361","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}