{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:21:25Z","timestamp":1787757685187,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Oro-facial-digital syndrome (OFD) is a disorder with varied inheritance patterns. They deal mainly with abnormalities of the face, digits, i.e., fingers and toes, and oral cavity. Hypoplasia of nasal alar cartilage, broad nasal bridge, frontal bossing, and micrognathia are the common facial abnormalities observed in its multiple potential forms. Among the oral features, lobulated tongue, multiple frenulae, and cleft lip\/palate are the common findings. The subject presented in our case manifested cleft of the hard palate at the time of presentation, along with other diverse features, which could not match any of the defined OFD types in literature. Furthermore, follow-up of the infant observed closure of the palate spontaneously, without any intervention. Hence, the purpose is to add to the knowledge the typical features of this unspecified type of OFD, along with this unique unprompted cleft palate closure, which aroused the need of close watch in such cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ccd.ccd_754_20","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T13:16:11Z","timestamp":1640092571000},"page":"454-458","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Oro-Facial-Digital Syndrome"],"prefix":"10.4103","volume":"12","author":[{"given":"Prashant Kumar","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nowneet Kumar","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-21-20240901","first-page":"47","article-title":"Oral-facial-digital syndrome Type I (clinical case)","volume":"285","author":"Horlenko","year":"2018","journal-title":"Georgian Med News"},{"key":"R2-21-20240901","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1016\/j.joms.2018.12.018","article-title":"Spontaneous bone regeneration after closure of the hard palate cleft: A literature review","volume":"77","author":"Scheuermann","year":"2019","journal-title":"J Oral Maxillofac Surg"},{"key":"R3-21-20240901","first-page":"697","article-title":"A comprehensive evaluation of an OFDI syndrome from child to teenager","volume":"60","author":"Belengeanu","year":"2019","journal-title":"Rom J Morphol Embryol"},{"key":"R4-21-20240901","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4103\/0970-9290.114920","article-title":"Orofacial digital syndrome","volume":"24","author":"Dave","year":"2013","journal-title":"Indian J Dent Res"},{"key":"R5-21-20240901","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4103\/0970-4388.130980","article-title":"Oro-facial-digital syndrome type 1: A case report","volume":"32","author":"Dhull","year":"2014","journal-title":"J Indian Soc Pedod Prev Dent"},{"key":"R6-21-20240901","doi-asserted-by":"crossref","first-page":"872","DOI":"10.4103\/njcp.njcp_451_18","article-title":"Papillon-Le\u00e1ge and psaume syndrome patient with multiple dental and orofacial anomalies","volume":"22","author":"Kilinc","year":"2019","journal-title":"Niger J Clin Pract"},{"key":"R7-21-20240901","doi-asserted-by":"crossref","first-page":"151","DOI":"10.4103\/0970-0358.44925","article-title":"Maxillonasal dysplasia (Binder's syndrome) and its treatment with costal cartilage graft: A follow-up study","volume":"41","author":"Bhatt","year":"2008","journal-title":"Indian J Plast Surg"},{"key":"R8-21-20240901","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/jmedgenet-2016-104436","article-title":"Fifteen years of research on oral-facial-digital syndromes: From 1 to 16 causal genes","volume":"54","author":"Bruel","year":"2017","journal-title":"J Med Genet"},{"key":"R9-21-20240901","first-page":"127","article-title":"Oral-facial-digital syndrome (OFD): 31-year follow-up management and monitoring","volume":"32","author":"Minervini","year":"2018","journal-title":"J Biol Regul Homeost Agents"},{"key":"R10-21-20240901","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s40368-015-0193-9","article-title":"Orofacial manifestations and dental considerations in association with Varadi-Papp syndrome: Report of a rare case","volume":"17","author":"Chhabra","year":"2016","journal-title":"Eur Arch Paediatr Dent"}],"container-title":["Contemporary Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_754_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:50:19Z","timestamp":1787755819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ccd.ccd_754_20"}},"subtitle":["Unspecified Type with the Spontaneous Fusion of Cleft Palate"],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/ccd.ccd_754_20","relation":{},"ISSN":["0976-237X"],"issn-type":[{"value":"0976-237X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}