{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:20:53Z","timestamp":1787847653610,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:p>Studies indicate that rapid weight gain at critical development stages, such as the lactation period, is associated with the development of obesity, cardiovascular diseases, and diabetes in the long term. In addition to metabolic changes during adulthood, overweight\/obesity may influence reproductive function. Human and animal studies suggest that lifestyle changes through exercise and\/or controlled diet result in improved semen quality in obese individuals. However, the relationship between exercise volume\/intensity and reproductive capacity effects remains inconclusive. The present study aimed to evaluate the effects of moderate intensity endurance training and high-intensity interval training (HIIT) on the reproductive parameters of lactating overfed male Wistar rats. Postnatal overfeeding was induced by applying the litter size reduction method. Forty males Wistar rats were used, divided into four groups: one with control litters (CLs) (10 animals\/litter-sedentary) and three with small litters (SLs) (4 animals\/litter), divided into sedentary, moderate endurance training, and HIIT. Morphologic, metabolic, and reproductive variables were analyzed. SL sedentary group showed increased body weight, adiposity, and decreased relative weight of the seminal vesicle, prostate, and epididymis as well as changes in the insulin tolerance and oral glucose tolerance tests glycemic tests compared to CL sedentary group. Endurance and HIIT protocols were efficient in improving the glycemic metabolism, central fat accumulation of trained groups and did not affect reproductive parameters. Endurance and HIIT protocols proved to be effective in reversing these metabolic changes without impairing the evaluated reproductive parameters.<\/jats:p>","DOI":"10.4103\/cjp.cjp_96_20","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T07:40:45Z","timestamp":1619595645000},"page":"106-114","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Moderate Intensity Endurance Training and High-Intensity Interval Training on the Reproductive Parameters of Wistar Rats Overfed in Infancy"],"prefix":"10.4103","volume":"64","author":[{"given":"Mariana","family":"Bolotari","sequence":"first","affiliation":[{"name":"Department of Medicine, Postgraduate Health Program, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Eliza","family":"Andreazzi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Postgraduate Health Program, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Gabriel","family":"de Lade","sequence":"additional","affiliation":[{"name":"Department of Medicine, Postgraduate Health Program, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinicius Moreira","family":"Gon\u00e7alves Costa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Postgraduate Health Program, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"de Oliveira Guerra","sequence":"additional","affiliation":[{"name":"Department of Medicine, Postgraduate Health Program, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera Maria","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Medicine, Postgraduate Health Program, Federal University of Juiz de Fora, Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,4,28]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10540-005-2888-3","article-title":"Neonatal programming of body weight regulation and energetic metabolism","volume":"25","author":"de Moura","year":"2005","journal-title":"Biosci Rep"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"409","DOI":"10.5812\/Kowsar.1726913X.3366","article-title":"Metabolic programming: Origin of non-communicable diseases in early life nutrition","volume":"9","author":"Kiani","year":"2011","journal-title":"Inter J Endocrinol Metab"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.mce.2013.09.008","article-title":"Fetal programming of sexual development and reproductive function","volume":"382","author":"Zambrano","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3945\/jn.112.172825","article-title":"Postnatal overfeeding in rodents by litter size reduction induces major short- and long-term pathophysiological consequences","volume":"143","author":"Habbout","year":"2013","journal-title":"J Nutr"},{"key":"R5-20240830","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.fertnstert.2009.01.100","article-title":"Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinic","volume":"93","author":"Chavarro","year":"2010","journal-title":"Fertil Steril"},{"key":"R6-20240830","doi-asserted-by":"crossref","first-page":"R123","DOI":"10.1530\/REP-17-0161","article-title":"Obesity, a serious etiologic factor for male subfertility in modern society","volume":"154","author":"Liu","year":"2017","journal-title":"Reproduction"},{"key":"R7-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4755-8-24","article-title":"Does weight loss improve semen quality and reproductive hormones? 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