{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:48:41Z","timestamp":1792900121281,"version":"4.5.0"},"reference-count":21,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\nBackground:<\/jats:title>\nHematolymphoid neoplasms (HLNs) presenting as body cavity effusions are not a common finding. They may be the first manifestation of the disease. A diagnosis on effusion cytology may provide an early breakthrough for effective clinical management.<\/jats:p>\n<\/jats:sec>\n\nAims:<\/jats:title>\nStudy the cytomorphology of HLNs in effusion cytology, determine common types, sites involved and uncover useful cytomorphologic clues to subclassify them.<\/jats:p>\n<\/jats:sec>\n\nMaterials and Methods:<\/jats:title>\nTwenty-four biopsy-proven HLN cases with malignant body cavity effusions and 8 cases suspicious for HLN on cytology but negative on biopsy are included in this study. Effusion cytology smears were reviewed for cytomorphological features: cellularity, cell size, nuclear features, accompanying cells, karyorrhexis, and mitoses.<\/jats:p>\n<\/jats:sec>\n\nResults:<\/jats:title>\nDiffuse large B-cell lymphoma (37%) was the most common lymphoma type presenting as effusion followed by peripheral T-cell lymphoma (25%). Pleural effusion (75%) was most frequent presentation followed by peritoneal effusion (20.8%). Pericardial effusion was rare (4.1%). The common cytologic features of HLNs in effusions: high cellularity, lymphoid looking cells with nuclear enlargement, dyscohesive nature, and accompanying small lymphocytes. Mitosis and karyorrhexis were higher in high-grade HLNs when compared to low-grade HLNs. Myelomatous effusion showed plasmacytoid cells. Very large, blastoid looking cells with folded nuclei, high N: C ratio, and prominent nucleoli were seen in leukemic effusion.<\/jats:p>\n<\/jats:sec>\n\nConclusion:<\/jats:title>\nHLNs have characteristic cytomorphology and an attempt to subclassify them should be made on effusion cytology. Reactive lymphocyte-rich effusions cannot be distinguished from low-grade lymphomas based on cytomorphology alone. Ancillary tests such as immunocytochemistry, flow cytometry, and\/or molecular techniques may prove more useful in this regard.<\/jats:p>\n<\/jats:sec>","DOI":"10.4103\/cytojournal.cytojournal_48_17","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T04:22:51Z","timestamp":1528950171000},"page":"15","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hematolymphoid neoplasms in effusion cytology"],"prefix":"10.25259","volume":"15","author":[{"given":"Vidya","family":"Monappa","sequence":"first","affiliation":[{"name":"Address: Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saritha M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Pathology, St Johns Medical College, Bengaluru, Karnataka, 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