{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:08:30Z","timestamp":1793606910571,"version":"4.5.0"},"reference-count":20,"publisher":"Scientific Scholar","content-domain":{"domain":["cytojournal.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>Ovarian cancer is a heterogeneous disease having the highest gynecologic fatality in the United States with a 5-year survival rate of 46.5%. Poor overall prognosis is mostly attributed to inadequate screening tools, and the majority of diagnoses occur at late stages of the disease. Due to genetic and biological underpinnings, ovarian high-grade serous carcinomas (HGSC) have etiologic evidence in the distal fallopian tube. Fallopian tube screening modalities are aggressively investigated, but few describe cytological characteristics of benign tubal specimens to help in the comparative detection of HGSC precursor cells. Here, we describe fimbrial cytomorphological and nuclear features of tubal specimens (<jats:italic>n<\/jats:italic> = 75) from patients clinically indicated for salpingectomy, bilateral or unilateral salpingo-oophorectomy, and hysterectomies for any diagnosis other than ovarian or peritoneal cancer. Fallopian tube histology was used as the diagnostic reference. A total of 75 samples had benign diagnoses. The benign cytological characteristics of fimbrial tubal specimens included ciliated cells in clustered arrangements with mild nuclear membrane irregularity, mild anisonucleosis, round and\/or oval nuclei, hyperchromatic chromatin, and mild nuclear membrane irregularity. In contrast, none of the cytology samples had spindle-shaped nuclei, significantly marked anisonucleosis (<jats:italic>n<\/jats:italic> = 1), nor had hypochromasia as a characteristic feature. These cytological characteristics could be a potential area of distinction from HGSC precursor cells. Our study establishes cytomorphological characteristics of nonmalignant tubal cells which help underscore the importance of distinguishing malignant HGSC precursors through fimbrial brush sampling in minimally invasive approach.<\/jats:p>","DOI":"10.4103\/cytojournal.cytojournal_58_17","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T07:44:23Z","timestamp":1542008663000},"page":"28","update-policy":"https:\/\/doi.org\/10.25259\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Cytology of the fallopian tube: A screening model for high-grade serous carcinoma"],"prefix":"10.25259","volume":"15","author":[{"given":"Maya","family":"Dhanani","sequence":"first","affiliation":[{"name":"Address: Department of Medical and Surgical Gynecology, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aziza","family":"Nassar","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa S.","family":"Charles","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, Loma Linda University School of Medicine, Loma Linda, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tri","family":"Dinh","sequence":"additional","affiliation":[{"name":"Address: Department of Medical and Surgical Gynecology, Mayo Clinic, Jacksonville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-1","article-title":"SEER Cancer Statistics Review, 1975-2015, National Cancer Institute","author":"Noone"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/AOG.0b013e318264f794","article-title":"Ten-year relative survival for epithelial ovarian cancer","volume":"120","author":"Baldwin","year":"2012","journal-title":"Obstet Gynecol"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-3","article-title":"The Next Four Decades, The Older Population in the United States: 2010 to 2050. Report No.: P25-1138","author":"Vincent","year":"2010"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-4","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1002\/cncr.29258","article-title":"The past, present, and future of cancer incidence in the United States: 1975 through 2020","volume":"121","author":"Weir","year":"2015","journal-title":"Cancer"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-5","doi-asserted-by":"crossref","first-page":"7547","DOI":"10.1073\/pnas.1017300108","article-title":"Modeling high-grade serous ovarian carcinogenesis from the fallopian tube","volume":"108","author":"Karst","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/PGP.0000000000000207","article-title":"Molecular alterations of TP53 are a defining feature of ovarian high-grade serous carcinoma: A Rereview of cases lacking TP53 mutations in the cancer genome atlas ovarian study","volume":"35","author":"Vang","year":"2016","journal-title":"Int J Gynecol Pathol"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/PAP.0b013e3181b4fffa","article-title":"Ovarian low-grade and high-grade serous carcinoma: Pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems","volume":"16","author":"Vang","year":"2009","journal-title":"Adv Anat Pathol"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-8","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/978-1-4419-0489-8_14","article-title":"Surface epithelial tumors of the ovary","volume-title":"Blaustein's Pathology of the Female Genital Tract","author":"Seidman","year":"2011","edition":"6th ed"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/path.2091","article-title":"A candidate precursor to serous carcinoma that originates in the distal fallopian tube","volume":"211","author":"Lee","year":"2007","journal-title":"J Pathol"},{"issue":"Suppl 2","key":"10.4103\/cytojournal.cytojournal_58_17\/ref-10","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1016\/j.ijgo.2015.06.007","article-title":"Cancer of the ovary, fallopian tube, and peritoneum","volume":"131","author":"Berek","year":"2015","journal-title":"Int J Gynaecol Obstet"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: Evidence for a causal relationship","volume":"31","author":"Kindelberger","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-12","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1200\/JCO.2008.16.4814","article-title":"Serous tubal intraepithelial carcinoma: Its potential role in primary peritoneal serous carcinoma and serous cancer prevention","volume":"26","author":"Carlson","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-13","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1001\/jama.2011.766","article-title":"Effect of screening on ovarian cancer mortality: The prostate, lung, colorectal and ovarian (PLCO) cancer screening randomized controlled trial","volume":"305","author":"Buys","year":"2011","journal-title":"JAMA"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-14","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0140-6736(15)01224-6","article-title":"Ovarian cancer screening and mortality in the UK collaborative trial of ovarian cancer screening (UKCTOCS): A randomised controlled trial","volume":"387","author":"Jacobs","year":"2016","journal-title":"Lancet"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-15","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1525-1438.2007.01035.x","article-title":"A randomized study of screening for ovarian cancer: A multicenter study in Japan","volume":"18","author":"Kobayashi","year":"2008","journal-title":"Int J Gynecol Cancer"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-16","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/bjc.2013.402","article-title":"Early detection of ovarian and fallopian tube cancer by examination of cytological samples from the endometrial cavity","volume":"109","author":"Otsuka","year":"2013","journal-title":"Br J Cancer"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-17","first-page":"404","article-title":"Serous tubal intraepithelial carcinoma arising from the intrauterine portion of the fallopian tube after bilateral salpingo-oophorectomy","volume":"37","author":"Yoshida","year":"2016","journal-title":"Eur J Gynaecol Oncol"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-18","article-title":"Tubal cytology of the fallopian tube as a promising tool for ovarian cancer early detection","volume":"125","author":"Chen","year":"2017","journal-title":"J Vis Exp"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-19","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1159\/000353825","article-title":"Cytologic findings in experimental in vivo fallopian tube brush specimens","volume":"57","author":"Rodriguez","year":"2013","journal-title":"Acta Cytol"},{"key":"10.4103\/cytojournal.cytojournal_58_17\/ref-20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ygyno.2017.04.015","article-title":"Frequency of \u201cincidental\u201d serous tubal intraepithelial carcinoma (STIC) in women without a history of or genetic risk factor for high-grade serous carcinoma: A six-year study","volume":"146","author":"Meserve","year":"2017","journal-title":"Gynecol Oncol"}],"container-title":["CytoJournal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/cytojournal.com\/cytology-of-the-fallopian-tube-a-screening-model-for-high-grade-serous-carcinoma\/","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/cytojournal.com\/cytology-of-the-fallopian-tube-a-screening-model-for-high-grade-serous-carcinoma\/","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,24]],"date-time":"2020-01-24T04:17:13Z","timestamp":1579839433000},"score":1,"resource":{"primary":{"URL":"https:\/\/cytojournal.com\/cytology-of-the-fallopian-tube-a-screening-model-for-high-grade-serous-carcinoma\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":20,"alternative-id":["10.4103\/cytojournal.cytojournal_58_17"],"URL":"https:\/\/doi.org\/10.4103\/cytojournal.cytojournal_58_17","relation":{},"ISSN":["0974-5963"],"issn-type":[{"value":"0974-5963","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]},"article-number":"28"}}