{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:13:10Z","timestamp":1788783190792,"version":"build-2803163510"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"ABSTRACT<\/jats:title>\n \n Background:<\/jats:title>\n This study compared bone regeneration in rabbit calvarial defects using two different xenografts with a barrier membrane by histological, histomorphometric, and micro-computed tomography (micro-CT) analyses.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n This study was designed as a single-blind interventional experimental animal study that conducted on 20 male New Zealand rabbits. The rabbits were anesthetized, a full-thickness mucoperiosteal flap was elevated, and four bone defects with 8 mm diameter were created in their calvaria at the two sides of their midsagittal suture. Two defects were randomly filled with Bio-Oss and NOVA xenografts. The other two defects remained empty. Except for one control defect, the remaining three were covered with a resorbable membrane. Ten rabbits were sacrificed after 4 and the remaining 10 after 8 weeks. Histological sections underwent micro-CT and histological assessments for new bone formation, bone maturation, residual particles, degree of inflammation, foreign body reaction, and soft-tissue formation.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The percentage of new bone formation increased at 8 weeks compared with 4 weeks and had a similar trend in Bio-Oss and NOVA groups (\n P<\/jats:italic>\n > 0.05). The percentage of new bone formation was slightly higher in defects with membrane at 8 weeks (\n P<\/jats:italic>\n > 0.05). The newly formed bone was a combination of woven and lamellar bone in all groups (\n P<\/jats:italic>\n > 0.05). Micro-CT showed no significant difference in bone microstructure. The difference in other parameters was not significant among the groups either (\n P<\/jats:italic>\n > 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Considering the similar rate of new bone formation and residual particles, both Bio-Oss and NOVA may be successfully used as scaffold with a barrier membrane for regeneration of bone defects.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/drj.drj_120_25","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:00:24Z","timestamp":1788782424000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of bone regeneration in rabbit calvarial defects following the use of two different xenografts with a barrier membrane: A histological, histomorphometric, and micro-computed tomography study"],"prefix":"10.4103","volume":"23","author":[{"given":"Maede","family":"Tamizi","sequence":"first","affiliation":[{"name":"Department of Periodontics, Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Birang","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Moghare","family":"Abed","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Dental Implants Research Center, School of Dentistry, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad","family":"Razavi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Dental Implant Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7]]},"reference":[{"key":"R1-20260907","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/clr.12395","article-title":"Defect healing with various bone substitutes","volume":"26","author":"Yip","year":"2015","journal-title":"Clin Oral Implants Res"},{"key":"R2-20260907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jdent.2016.03.010","article-title":"Comparative effectiveness of natural and synthetic bone grafts in oral and maxillofacial surgery prior to insertion of dental implants: Systematic review and network meta-analysis of parallel and cluster randomized controlled trials","volume":"48","author":"Papageorgiou","year":"2016","journal-title":"J Dent"},{"key":"R3-20260907","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3390\/ma11102004","article-title":"Bone healing in rabbit calvaria defects using a synthetic bone substitute: A histological and micro-CT comparative study","volume":"11","author":"Leventis","year":"2018","journal-title":"Materials (Basel)"},{"key":"R4-20260907","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1600-0501.2005.01257.x","article-title":"Bone healing and graft resorption of autograft, anorganic bovine bone and beta-tricalcium phosphate. 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