{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:09Z","timestamp":1787840769850,"version":"build-2784847793"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The goal of this study was to assess the techniques used in earlier conducted clinical investigations on the chemomechanical eradication of dentinal caries, as well as to assess the variances in pain perception, the time required for complete caries excavation, and how microbiological analysis compared before and following caries removal in primary teeth for both Papacarie and Carisolv.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>An electronic search was conducted utilizing the databases PubMed, Google Scholar, EBSCOhost, Scopus, and the Cochrane Library. The following categories were included during the assessment process: full text randomized and controlled clinical trials published between January 2000 and December 2021 in the English language only. Adolescent and child patients with open dentinal carious lesion in primary teeth were included. The methodology of the seven clinical studies chosen was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Findings of the study reported that the microbiota in carious dentine was dramatically reduced with the Papacarie therapy, and the pain perception decreased more in the Papacarie group, whereas Carisolv treatment took longer time for complete caries excavation as compared to Papacarie.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In conclusion, Papacarie had a beneficial impact by decreasing pain and time taken during caries excavation in primary teeth. The tooth surface treated with Papacarie also demonstrated a reduced bacterial count as compared to Carisolv chemomechanical caries removal approach. Overall, Papacarie and Carisolv are viable minimally invasive and painless techniques for effective caries removal in pediatric patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/drj.drj_205_23","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T06:00:09Z","timestamp":1756101609000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Comparative evaluation of Papacarie and Carisolv in effective chemomechanical carious dentin removal in primary teeth: A systematic review"],"prefix":"10.4103","volume":"22","author":[{"given":"Mahesh Vilasrao","family":"Dadpe","sequence":"first","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, MIDSR Dental College, Latur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja Balaji","family":"Shelke","sequence":"additional","affiliation":[{"name":"Department of Pediatric 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