{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:19:43Z","timestamp":1787771983277,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Dentinogenic ghost cell tumor (DGCT) is a rare odontogenic neoplasm, representing a solid variant of the calcifying odontogenic cyst (COC), accounting for 2%\u201314% of all COCs and &lt;0.5% of odontogenic tumors. Its unique histological and clinical characteristics, coupled with its potential for local invasiveness, underscore the necessity for accurate diagnosis and management. This article reports two cases of DGCT Case 1involves a 13-year-old boy presented with the absence of permanent teeth 4 and 5. Radiographic examinations revealed a mixed radiolucent\u2013radiopaque lesion in the left mandible associated with the impacted permanent teeth. The lesion exhibited well-defined borders and significant calcifications. Microscopic analysis revealed islands of odontogenic epithelium with features resembling ameloblasts, numerous ghost cells, and areas of dystrophic calcification, confirming the diagnosis of DGCT. Case 2 involves A 67-year-old male presented with an exophytic lesion on the left side of the mandibular alveolar mucosa. On pathologic examination, the sample revealed features that led to the diagnosis of a peripheral DGCT. In the first case, given the lesion\u2019s size and location, a surgical excision was performed using an intraoral approach under general anesthesia, including a margin of healthy tissue. Short-term follow-ups were conducted every 3 months, and no recurrence was noted after 6 months. In the second case, an excision biopsy and short-term follow-up were conducted. This case highlights the clinical presentation, radiographic features, and histopathological characteristics of two cases of DGCT, emphasizing the importance of surgical intervention and regular follow-up in managing this rare neoplasm. Enhanced awareness and understanding of DGCT are essential for timely diagnosis and effective treatment, particularly in pediatric patients presenting with dental abnormalities.<\/jats:p>","DOI":"10.4103\/drj.drj_212_25","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T07:00:26Z","timestamp":1772089226000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Dentinogenic ghost cell tumor: Two case reports and review of the literature"],"prefix":"10.4103","volume":"23","author":[{"given":"Neda","family":"Kargahi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Dental Research Center, Dental Research Institute, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvin","family":"Mahzoni","sequence":"additional","affiliation":[{"name":"Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbass","family":"Haghighat","sequence":"additional","affiliation":[{"name":"Departments of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Khozeimeh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nedasadat","family":"Mirmohammadsadeghi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Dental Students\u2019 Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahya","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology, Dental Students\u2019 Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2]]},"reference":[{"key":"R1-20260226","doi-asserted-by":"crossref","first-page":"192","DOI":"10.5306\/wjco.v10.i4.192","article-title":"Dentinogenic ghost cell tumor: A case report","volume":"10","author":"Patankar","year":"2019","journal-title":"World J Clin Oncol"},{"key":"R2-20260226","doi-asserted-by":"crossref","first-page":"e936787","DOI":"10.12659\/AJCR.936787","article-title":"Recurrent dentinogenic ghost cell tumor: A case report","volume":"23","author":"Alzaid","year":"2022","journal-title":"Am J Case Rep"},{"key":"R3-20260226","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11282-024-00764-4","article-title":"Central dentinogenic ghost cell tumor of the maxilla: A case report with new imaging findings and review of the literature","volume":"40","author":"Yoshida","year":"2024","journal-title":"Oral Radiol"},{"key":"R4-20260226","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s12105-021-01347-z","article-title":"Comparative analysis between dentinogenic ghost cell tumor and ghost cell odontogenic carcinoma: A systematic review","volume":"15","author":"de Souza Vieira","year":"2021","journal-title":"Head Neck Pathol"},{"key":"R5-20260226","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13256-023-03861-w","article-title":"Dentinogenic ghost cell tumor treated with a combination of marsupialization and radical resection: A case report and review of the literature","volume":"17","author":"Toyodome","year":"2023","journal-title":"J Med Case Rep"},{"key":"R6-20260226","doi-asserted-by":"crossref","first-page":"148","DOI":"10.17796\/1053-4625-46.2.10","article-title":"Dentinogenic ghost cell tumor associated with odontoma: A unique histopathological entity and its surgical management","volume":"46","author":"Urs","year":"2022","journal-title":"J Clin Pediatr Dent"},{"key":"R8-20260226","doi-asserted-by":"crossref","first-page":"e7442","DOI":"10.1002\/ccr3.7442","article-title":"Arare case of dentinogenic ghost cell tumor with concomitant odontoma","volume":"11","author":"Okui","year":"2023","journal-title":"Clin Case Rep"},{"key":"R9-20260226","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1308\/003588413X13511609957010","article-title":"Maxillary dentinogenic ghost cell tumour","volume":"95","author":"Biggs","year":"2013","journal-title":"Ann R Coll Surg Engl"}],"container-title":["Dental Research Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/drj.drj_212_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:23:43Z","timestamp":1787768623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/drj.drj_212_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":8,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/drj.drj_212_25","relation":{},"ISSN":["1735-3327","2008-0255"],"issn-type":[{"value":"1735-3327","type":"print"},{"value":"2008-0255","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"2025-04-26","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}