{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:42:40Z","timestamp":1786725760092,"version":"build-2736575974"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objective of the study was to evaluate caries development and retention rate of resin-based hydrophilic and hydrophobic fissure sealants based on the randomized clinical trials in which the investigators have studied this subject.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A literature screen was conducted in some databases, including PubMed, Scopus, Embase, ISI Web of Science, and Cochrane Library, to select randomized clinical trials that compared the caries development\/retention rate of resin-based hydrophilic and hydrophobic fissure sealants until March 2025. The risk of bias of the included studies was assessed using version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2), and the meta-analysis was performed using a random-effect model. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 20,945 articles were initially retrieved for screening, and fourteen studies were identified as eligible for inclusion in the quantitative analysis. The RoB assessment showed a high risk of bias in 5 studies, some concerns in 5, and low risk in 4. Caries development was reported in 11 studies, and retention rate in 14. The meta-analysis results showed a statistically significant difference for caries development (odds ratio [OR]: 0.490, 95% confidence interval [CI]: 0.277\u20130.867;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.014), whereas the retention rate (OR: 0.859, 95% CI: 0.596\u20131.237;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.414) indicated no statistically significant differences. The quality of evidence for both outcomes was rated as very low according to the GRADE system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It could be concluded that hydrophilic and hydrophobic resin-based fissure sealants are approximately equal in caries development and retention rate, with very low quality of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance:<\/jats:title>\n                    <jats:p>In clinical practice, resin-based hydrophilic fissure sealants could be applied on susceptible tooth surfaces; in case of difficult isolation, with an almost equal clinical success for hydrophobic fissure sealants.<\/jats:p>\n                  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