{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:33:29Z","timestamp":1787070809753,"version":"build-2736575974"},"reference-count":75,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis aimed to assess the efficacy of autologous platelet concentrate (APCs) in comparison with coronally-advanced flap alone or in combination with connective tissue graft or other biomaterials or bioactive agents for root coverage (RC) of Miller\u2019s Class I and II gingival recession defects by measuring the keratinized mucosa width (KMW).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines. An electronic search of the literature was conducted in PubMed, EMBASE, Scopus, Cochrane, Web of Science, Magiran, Scientific Information Database, and Irandoc for randomized clinical trials (RCTs) that used APCs for RC in their intervention group. Eligible articles were retrieved by assessment of titles and abstracts and then the full texts. The risk of bias was assessed by the Cochrane Library Risk of Bias Assessment Tool. Meta-analysis was carried out by RevMan 5.3 software. In the case of homogeneity, variables were reported as weighted mean difference (WMD) with 95% confidence interval (CI) for each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The search yielded 689 articles; out of which, 32 were eligible for study inclusion. Meta-analysis did not show any additional effect for RC and KMW with APCs. Clinical parameters were as follows: RC: WMD = \u22121.57 mm (95% CI: \u22122.49, \u22120.659;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) and KMW: \u22120.106 mm (95% CI: \u22120.3222, 0.110;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.337).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The application of APCs for RC of Miller\u2019s Class I and II gingival recession defects does not seem to improve the clinical parameters.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/drj.drj_437_22","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T01:06:49Z","timestamp":1732669609000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of autologous platelet concentrates for root coverage of Miller\u2019s Class I and II gingival recession defects: A systematic review and meta-analysis"],"prefix":"10.4103","volume":"21","author":[{"given":"Jaber","family":"Yaghini","sequence":"first","affiliation":[{"name":"Department of Periodontology, Dental Implant Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Mogharehabed","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Implant Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awat","family":"Feizi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Yazdanfar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Dental Student\u2019s Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11]]},"reference":[{"key":"R1-20241127","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1902\/jop.2010.090237","article-title":"Clinical evaluation of single-stage advanced versus rotated flaps in the treatment of gingival recessions","volume":"81","author":"Santana","year":"2010","journal-title":"J Periodontol"},{"key":"R3-20241127","article-title":"Periodontologia clinica e implantologia odontologica\/Clinical Periodontology and Implant Dentistry","author":"Lindhe","year":"2009","journal-title":"M\u00e9dica Panamericana"},{"key":"R4-20241127","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2842.1982.tb01032.x","article-title":"A retrospective study of the fit of jacket crowns placed around gold posts and cores, and the associated gingival health","volume":"9","author":"Turner","year":"1982","journal-title":"J Oral Rehabil"},{"key":"R5-20241127","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1902\/jop.1973.44.3.158","article-title":"Root surface caries: Review of the literature and significance of the problem","volume":"44","author":"Jordan","year":"1973","journal-title":"J Periodontol"},{"key":"R6-20241127","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1902\/jop.2016.150625","article-title":"Long-term outcomes of untreated buccal gingival recessions: A systematic review and meta-analysis","volume":"87","author":"Chambrone","year":"2016","journal-title":"J Periodontol"},{"key":"R7-20241127","article-title":"Oral health of United States adults","author":"Miller","year":"1987","journal-title":"The National Survey of Oral Health in US Employed Adults and Seniors, 1985-86"},{"key":"R8-20241127","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1902\/jop.2015.130674","article-title":"Periodontal soft tissue root coverage procedures: A systematic review from the AAP regeneration workshop","volume":"86","author":"Chambrone","year":"2015","journal-title":"J Periodontol"},{"key":"R9-20241127","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1902\/jop.2000.71.9.1506","article-title":"Treatment of multiple recession-type defects in patients with esthetic demands","volume":"71","author":"Zucchelli","year":"2000","journal-title":"J Periodontol"},{"key":"R10-20241127","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1902\/jop.2000.71.2.188","article-title":"Coronally advanced flap procedure for root coverage. 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