{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:45:53Z","timestamp":1787071553587,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"ABSTRACT<\/jats:title>\n \n Background:<\/jats:title>\n Accurate and early diagnosis of dysplastic lesions is crucial for successful treatment. A decrease in E-cadherin expression has been observed in dysplastic lesions and tumors. Therefore, the aim of this study was to investigate the expression of E-cadherin, a cell membrane adhesive protein involved in tissue structure and differentiation, in oral reticular lichen planus, erosive lichen planus, and lichenoid lesions.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This descriptive cross-sectional study was conducted on 65 oral samples (20 reticular lichen planus, 20 erosive lichen planus, and 20 lichenoid lesions, with 5 samples of healthy mucosa), to evaluate the expression of E-cadherin using immunohistochemical methods. Data were analyzed using SPSS software (version 25), descriptive statistics, Chi-square tests, and Fisher\u2019s exact tests, with a significance threshold set at\n P<\/jats:italic>\n < 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The majority of patients were female (72.3%) and primarily in the sixth and seventh decades of life (49.2%). A significant difference was observed between the studied groups regarding staining status (\n P<\/jats:italic>\n = 0.038), with erosive lichen planus showing the highest frequency of alterations in E-cadherin expression (45%). In addition, a significant difference was noted between staining status and lesion location (\n P<\/jats:italic>\n = 0.004), with the highest frequency of E-cadherin expression changes occurring in buccal mucosal samples (30%).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n E-cadherin expression in erosive lichen planus is significantly lower than in healthy tissue, reticular lichen planus, and lichenoid lesions. Given the similar reduction observed in squamous cell carcinoma samples, evaluating E-cadherin expression may aid in the early recognition of malignant changes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/drj.drj_447_23","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:00:16Z","timestamp":1758628816000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparative study of E-cadherin expression between reticular, erosive oral lichen planus and lichenoid lesions"],"prefix":"10.4103","volume":"22","author":[{"given":"Laleh","family":"Maleki","sequence":"first","affiliation":[{"name":"Dental Research Center, Department of Oral and Maxillofacial Pathology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Jahanshahi","sequence":"additional","affiliation":[{"name":"Dental Research Center, Department of Oral and Maxillofacial Pathology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Forooz","family":"Keshani","sequence":"additional","affiliation":[{"name":"Dental Research Center, Department of Oral and Maxillofacial Pathology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samira Fotoohi","family":"Ashiin","sequence":"additional","affiliation":[{"name":"Dental Students Research Committee, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9]]},"reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s12105-019-01020-6","article-title":"Oral epithelial dysplasia and premalignancy","volume":"13","author":"Woo","year":"2019","journal-title":"Head Neck Pathol"},{"key":"R2-20250925","first-page":"323","article-title":"Molecular analysis of oral lichen planus. 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