{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:18:31Z","timestamp":1785251911750,"version":"3.55.0"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":533,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\n          Objective: Oxidative stress (OS) refers to the disequilibrium between free radicals and antioxidant defense mechanisms and is significantly implicated in the pathogenesis of chronic degenerative and inflammatory diseases such as chronic periodontal disease (CP) and diabetes mellitus (DM). This study aimed to evaluate the total antioxidants capacity (TAOC) and total oxidants status (TOS) in the gingival crevicular fluid (GCF) in CP participants with type II DM. Materials and Methods: A total of 80 participants were allotted into four groups as follows: Group 1: Generalized CP (GCP) without type II DM (n = 20); Group 2: GCP with type II DM (n = 20); Group 3: Type II DM without CP (n = 20); and Group 4: Systemically and periodontally healthy (PH) (n = 20). Clinical parameters such as plaque index, gingival index, probing pocket depth, and clinical attachment level were recorded. Pooled GCF was collected followed by the estimation of TAOC, TOS, and OS index (OSI) using Erel O Colorimetric analysis. Results: The clinical parameters recorded showed the statistically significant difference (P &lt; 0.001) between the groups. The mean TAOC value was the highest in PH group. The mean TOS and OSI were higher in Group 1, 2, and 3 participants when compared to the PH participants. All the biochemical parameters evaluated showed a statistically significant difference (P &lt; 0.001) between groups. Conclusions: The study further validates the use of OSI as a marker for periodontal disease activity and emphasizes the role of OS in the pathogenesis of Type II diabetic patients with the chronic periodontal disease.<\/jats:p>","DOI":"10.4103\/ejd.ejd_244_17","type":"journal-article","created":{"date-parts":[[2018,6,7]],"date-time":"2018-06-07T09:40:35Z","timestamp":1528364435000},"page":"225-231","source":"Crossref","is-referenced-by-count":33,"title":["Oxidative stress in chronic periodontitis patients with type II diabetes mellitus"],"prefix":"10.1055","volume":"12","author":[{"given":"Ruby Ramya","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devapriya","family":"Appukuttan","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhayanand John","family":"Victor","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Balasundaram","sequence":"additional","affiliation":[{"name":"Department of Periodontics, SRM Dental College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"key-10.4103\/1305-7456.233860-1","first-page":"409","volume-title":"Beyond the red complex and into more complexity: The polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology","author":"Hajishengallis","year":"2012","journal-title":"Mol Oral Microbiol"},{"key":"key-10.4103\/1305-7456.233860-2","first-page":"66","volume-title":"The bacteria of periodontal 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