{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:37:18Z","timestamp":1781307438952,"version":"3.54.1"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":730,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>\nObjectives: The aim of this study was to evaluate and assess knowledge and attitude of dental students about medication-related osteonecrosis of the jaw (MRONJ), to optimize future training programs in this field. Materials and Methods: A cross-sectional study was administrated. Ninety-eight participants agreed to complete an anonymous questionnaire. It was divided into two sections: the first section was about general information such as interviewer's gender and date of birth; the second section included questions about bisphosphonates (BPs), others medication associated to osteonecrosis of the jaw (ONJ), risk factors, and prevention of osteonecrosis. Descriptive statistics were computed and the odds ratio was used to compare the odds for the groups. Results: Ninety-nine percent of participants declared to know BPs, but only 26.9% of 4th year and 34.8% of 6th year students knew the correct definition of MRONJ. Almost all of students identified the importance to report, in anamnesis, the use of BPs, as well as to check-up patients before the beginning of treatment; on the other hand, the knowledge about how invasive dental treatment might be carried out in patients under therapy was not adequate. In addition, half of the students did not recognize any active principle or commercial name of BPs. The situation was even worse regarding alternative drugs involved in ONJ. Conclusions: These findings are alarming and the lack of knowledge about MRONJ suggests that greater educational efforts should be performed about this pathology at undergraduate level.\n<\/jats:p>","DOI":"10.4103\/ejd.ejd_27_17","type":"journal-article","created":{"date-parts":[[2017,11,24]],"date-time":"2017-11-24T05:32:28Z","timestamp":1511501548000},"page":"461-468","source":"Crossref","is-referenced-by-count":27,"title":["Dental students' knowledge of medication-related osteonecrosis of the jaw"],"prefix":"10.1055","volume":"11","author":[{"given":"Daniele","family":"Rosella","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo-Facial Sciences, \u201cSapienza\u201d University of Rome, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Papi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo-Facial Sciences, \u201cSapienza\u201d University of Rome, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Pompa","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo-Facial Sciences, \u201cSapienza\u201d University of Rome, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Capogreco","sequence":"additional","affiliation":[{"name":"Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo-Facial Sciences, \u201cSapienza\u201d University of Rome, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo-Facial Sciences, \u201cSapienza\u201d University of Rome, Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2019,10,1]]},"reference":[{"key":"key-10.4103\/1305-7456.219180-1","first-page":"1938","volume-title":"American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw-2014 update","author":"Ruggiero","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/1305-7456.219180-2","first-page":"2","volume-title":"American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws--2009 update","author":"Ruggiero","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/1305-7456.219180-3","first-page":"420","volume-title":"Guidance on the use of bisphosphonates in solid tumours: Recommendations of an international expert panel","author":"Aapro","year":"2008","journal-title":"Ann Oncol"},{"key":"key-10.4103\/1305-7456.219180-4","first-page":"1771","volume-title":"Malignancy associated hypercalcaemia-responsiveness to IV bisphosphonates and prognosis in a palliative population","author":"Mallik","year":"2016","journal-title":"Support Care Cancer"},{"key":"key-10.4103\/1305-7456.219180-5","first-page":"3483","volume-title":"Prospective observational study of treatment pattern, effectiveness and safety of zoledronic acid therapy beyond 24 months in patients with multiple myeloma or bone metastases from solid tumors","author":"Van","year":"2013","journal-title":"Support Care Cancer"},{"key":"key-10.4103\/1305-7456.219180-6","first-page":"301","volume-title":"Treatment of postmenopausal osteoporosis with delayed-release risedronate 35 mg weekly for 2 years","author":"McClung","year":"2013","journal-title":"Osteoporos Int"},{"key":"key-10.4103\/1305-7456.219180-7","first-page":"311","volume-title":"Effect of oral monthly ibandronate on bone microarchitecture in women with osteopenia-a randomized placebo-controlled trial","author":"Chapurlat","year":"2013","journal-title":"Osteoporos Int"},{"key":"key-10.4103\/1305-7456.219180-8","first-page":"1424","volume-title":"Risedronate in children with osteogenesis imperfecta: A randomised, double-blind, placebo-controlled trial","author":"Bishop","year":"2013","journal-title":"Lancet"},{"key":"key-10.4103\/1305-7456.219180-9","first-page":"468","volume-title":"Efficacy, tolerability, and safety of risedronate in Japanese patients with Paget's disease of bone","author":"Yoh","year":"2010","journal-title":"J Bone Miner Metab"},{"key":"key-10.4103\/1305-7456.219180-10","first-page":"325","volume-title":"Clinical potential of RANKL inhibition for the management of postmenopausal osteoporosis and other metabolic bone diseases","author":"Delmas","year":"2008","journal-title":"J Clin Densitom"},{"key":"key-10.4103\/1305-7456.219180-11","first-page":"813","volume-title":"Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: A randomised, double-blind study","author":"Fizazi","year":"2011","journal-title":"Lancet"},{"key":"key-10.4103\/1305-7456.219180-12","first-page":"97","volume-title":"Medication-related osteonecrosis of the jaw: Clinical and practical guidelines","author":"Rosella","year":"2016","journal-title":"J Int Soc Prev Community Dent"},{"key":"key-10.4103\/1305-7456.219180-13","first-page":"117","volume-title":"Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid","author":"Dimopoulos","year":"2009","journal-title":"Ann Oncol"},{"key":"key-10.4103\/1305-7456.219180-14","first-page":"137","volume-title":"Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates.The experience of the National Cancer Institute of Milan","author":"Ripamonti","year":"2009","journal-title":"Ann Oncol"},{"key":"key-10.4103\/1305-7456.219180-15","first-page":"11","volume-title":"Bisphosphonates and Osteonecrosis of the jaw: The oral surgeon's perspective","author":"Pompa","year":"2012","journal-title":"Eur J Inflamm"},{"key":"key-10.4103\/1305-7456.219180-16","first-page":"1341","volume-title":"Incidence, risk factors, and outcomes of osteonecrosis of the jaw: Integrated analysis from three blinded active-controlled phase III trials in cancer patients with bone metastases","author":"Saad","year":"2012","journal-title":"Ann Oncol"},{"key":"key-10.4103\/1305-7456.219180-17","first-page":"243","volume-title":"Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure","author":"Lo","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/1305-7456.219180-18","first-page":"193","volume-title":"Impact of dental care in the prevention of bisphosphonate-associated 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