{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T04:28:24Z","timestamp":1649219304921},"reference-count":8,"publisher":"Georg Thieme Verlag KG","issue":"03","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":442,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Dent"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Patients with plasma cell myeloma may initially present to their dentists or dental surgeons with toothache, loose teeth, or gingival masses. An X-ray of the jaw can reveal osteolyses. In addition, accumulation of monoclonal light chains in AL-amyloidosis can lead to macroglossia. It is prudent that the dentist or dental surgeon recognizes the underlying disease and refers the patient to the oncologist or hematologist for further workup to prevent the complications of plasma cell myeloma such as renal impairment, fractures, bone pain, infections, hypercalcemia, anemia, or heart failure. Another area where the dentist or dental surgeon is involved with patients suffering from plasma cell myeloma is prevention and therapy of osteonecrosis of the jaw, occurring after administration of bisphosphonates or denosumab for osteolytic bone disease. The case report presented here shows a patient complaining of toothache for whom recognition of a systemic disease by the dentist led to the diagnosis of plasma cell myeloma, highlighting the need for interdisciplinary cooperation. As recent years have seen many changes in the management of patients with plasma cell myeloma, an update for dentists and dental surgeons is warranted.<\/jats:p>","DOI":"10.4103\/ejd.ejd_412_17","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T11:25:29Z","timestamp":1533036329000},"page":"443-445","source":"Crossref","is-referenced-by-count":0,"title":["Toothache as the initial symptom of plasma cell myeloma"],"prefix":"10.1055","volume":"12","author":[{"given":"Tobias","family":"Wehrhahn","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hematology and Transfusion Medicine, Cantonal Hospital Aarau, Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Bargetzi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Hematology and Transfusion Medicine, Cantonal Hospital Aarau, Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Buitrago-Tellez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Spital Zofingen, Zofingen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Cantelmi","sequence":"additional","affiliation":[{"name":"Private Practice, Zofingen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"key-10.4103\/1305-7456.237870-1","unstructured":"McKenna RW, Kyle RA, Kuehl WM, Harris NL, Coupland RW, Fend F. Plasma cell neoplasms. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al., editors. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th ed. Lyon: IARC; 2017."},{"key":"key-10.4103\/1305-7456.237870-2","first-page":"2197","volume-title":"Multiple myeloma","author":"R\u00f6llig","year":"2015","journal-title":"Lancet"},{"key":"key-10.4103\/1305-7456.237870-3","first-page":"e538","volume-title":"International myeloma working group updated criteria for the diagnosis of multiple myeloma","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"key":"key-10.4103\/1305-7456.237870-4","first-page":"w14100","volume-title":"Current status and updated recommendations for diagnosis and treatment of plasma cell myeloma in Switzerland","author":"Samaras","year":"2015","journal-title":"Swiss Med Wkly"},{"key":"key-10.4103\/1305-7456.237870-5","doi-asserted-by":"crossref","unstructured":"Shah A, Latoo S, Ahmad I. Multiple myeloma and dentistry. In: Gupta A, editor. Multiple Myeloma \u2013 An Overview; 2012. Available from: https:\/\/www.intechopen.com\/books\/multiple-myeloma-an-overview\/multiple-myeloma-and-dentistry. [Last accessed on 2018 Jul 15].","DOI":"10.5772\/31490"},{"key":"key-10.4103\/1305-7456.237870-6","first-page":"209","volume-title":"Multiple myeloma presenting as gingival mass","author":"Shah","year":"2010","journal-title":"J Maxillofac Oral Surg"},{"key":"key-10.4103\/1305-7456.237870-7","first-page":"55","volume-title":"Multiple myeloma presenting with a maxillary lesion as the first sign","author":"Ramaiah","year":"2015","journal-title":"Imaging Sci Dent"},{"key":"key-10.4103\/1305-7456.237870-8","first-page":"2863","volume-title":"Revised international staging system for multiple myeloma: A report from international myeloma working group","author":"Palumbo","year":"2015","journal-title":"J Clin Oncol"}],"container-title":["European Journal of Dentistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/ejd.ejd_412_17.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T15:22:18Z","timestamp":1571671338000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/ejd.ejd_412_17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":8,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2019,9,16]]},"published-print":{"date-parts":[[2018,7]]}},"URL":"https:\/\/doi.org\/10.4103\/ejd.ejd_412_17","relation":{},"ISSN":["1305-7456","1305-7464"],"issn-type":[{"value":"1305-7456","type":"print"},{"value":"1305-7464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]}}}