{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:48:45Z","timestamp":1770742125590,"version":"3.49.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Background and Objectives:<\/jats:title>\n            <jats:p>Endoscopic therapy is an option for the treatment of refractory gastroesophageal reflux disease (GERD). We aimed to evaluate the efficacy and safety of transoral incisionless fundoplication with the Medigus ultrasonic surgical endostapler (MUSE\u2122) for refractory GERD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Materials and Methods:<\/jats:title>\n            <jats:p>Patients with 2 years of documented GERD symptoms and at least 6 months of proton-pump inhibitors (PPIs) therapy were enrolled in four medical centers from March 2017 to March 2019. The GERD health-related quality of life (HRQL) score, GERD questionnaire score, total acid exposure on esophageal pH probe monitoring, the gastroesophageal flap valve (GEFV), esophageal manometry, and PPIs dosage were compared between the pre- and post-MUSE procedure. All of the side effects were recorded.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>A reduction of at least 50% in the GERD-HRQL score was observed in 77.8% (42\/54) patients. Most patients 74.1% (40\/54) discontinued PPIs and 11.1% (6\/54) reported a \u226550% dose reduction. The percentage of patients who had normalized acid exposure time after the procedure was 46.9% (23\/49). The existence of hiatal hernia at baseline was negatively correlated with the curative effect. Mild pain was common and resolved within 48 h postprocedure. Serious complications were pneumoperitoneum (one case), mediastinal emphysema combined with pleural effusion (two cases).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Endoscopic anterior fundoplication with MUSE was an effective treatment for refractory GERD, but still needs refinement and improvement in safety aspect. Esophageal hiatal hernia may affect the efficacy of MUSE. (www.chictr.org.cn, ChiCTR2000034350)<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/eus-d-21-00244","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T06:53:44Z","timestamp":1654671224000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of endoscopic anterior fundoplication with a novel ultrasonic surgical endostapler for gastroesophageal reflux disease: Six-month results from a multicenter prospective trial"],"prefix":"10.1097","volume":"12","author":[{"given":"Lihua","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai First People\u2019s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengliang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Renji Hospital of Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jimin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroesophageal Reflux Disease, Chinese PLA Rocket Force Characteristic Medical Center, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunsheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, The First Medical Center, Chinese PLA General Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2022,6,8]]},"reference":[{"key":"R1-20250826","first-page":"1","article-title":"Review of antireflux procedures for proton pump inhibitor nonresponsive gastroesophageal reflux disease","volume":"30","author":"Hillman","year":"2017","journal-title":"Dis Esophagus"},{"key":"R2-20250826","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1111\/dote.12374","article-title":"Factors associated with nonresponse to proton pump inhibitors therapy in patients referred for esophageal pH-impedance monitoring","volume":"29","author":"Garros","year":"2016","journal-title":"Dis Esophagus"},{"key":"R3-20250826","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/bcpt.13023","article-title":"Side effects of long-term proton pump inhibitor use:A review","volume":"123","author":"Haastrup","year":"2018","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"R4-20250826","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5056\/jnm18001","article-title":"Advantages and disadvantages of long-term proton pump inhibitor use","volume":"24","author":"Kinoshita","year":"2018","journal-title":"J Neurogastroenterol Motil"},{"key":"R5-20250826","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s12664-017-0796-7","article-title":"Treatment of gastroesophageal reflux disease using radiofrequency ablation (Stretta procedure):An interim analysis of a randomized trial","volume":"36","author":"Kalapala","year":"2017","journal-title":"Indian J Gastroenterol"},{"key":"R6-20250826","doi-asserted-by":"crossref","first-page":"173","DOI":"10.21614\/chirurgia.113.2.173","article-title":"Transoral incisionless fundoplication (TIF 2.0):A meta-analysis of three randomized, controlled clinical trials","volume":"113","author":"Gerson","year":"2018","journal-title":"Chirurgia 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Ther"},{"key":"R13-20250826","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00423-017-1606-5","article-title":"Modern diagnosis and treatment of hiatal hernias","volume":"402","author":"Siegal","year":"2017","journal-title":"Langenbecks Arch Surg"},{"key":"R14-20250826","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1007\/s00464-017-5431-2","article-title":"Systematic review and meta-analysis of controlled and prospective cohort efficacy studies of endoscopic radiofrequency for treatment of gastroesophageal reflux disease","volume":"31","author":"Fass","year":"2017","journal-title":"Surg Endosc"},{"key":"R15-20250826","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/den.13727","article-title":"Endoscopic treatment of proton pump inhibitor-refractory gastroesophageal reflux disease with anti-reflux mucosectomy:Experience of 109 cases","volume":"33","author":"Sumi","year":"2021","journal-title":"Dig Endos"},{"key":"R16-20250826","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12876-020-01310-2","article-title":"Stretta radiofrequency treatment vs. Toupet fundoplication for gastroesophageal reflux disease:A comparative study","volume":"20","author":"Ma","year":"2020","journal-title":"BMC Gastroenterol"}],"container-title":["Endoscopic 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