{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:07:55Z","timestamp":1784552875790,"version":"3.55.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to compare the efficacy of rectal misoprostol combined with intramyometrial normal saline versus intramyometrial vasopressin in reducing blood loss during laparoscopic myomectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This was a randomized, double blind, controlled trial (CTRI\/2023\/05\/053204). A total of 70 women scheduled for laparoscopic myomectomy were enrolled and equally randomized into two groups: Group I (received rectal misoprostol 400 \u00b5g 1 h before surgery) and Group II (received intramyometrial vasopressin 20 IU in 200 ml NS dilution). Final analysis was conducted on 64 patients due to missing data (4 in Group I and 2 in Group II). The primary outcome was intraoperative blood loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Baseline clinical characteristics were similar between the groups. Intraoperative blood loss was significantly higher in the misoprostol Group I compared to the vasopressin Group II (320.9 \u00b1 131.9 mL vs. 246 \u00b1 119.3 mL;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). Similarly, the mean drop in hemoglobin was greater in Group I (2.38 \u00b1 1 g\/dL) than in Group II (1.5 \u00b1 1.2 g\/dL;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). Although operative time was longer in Group I (median [95% confidence interval]: 120 [90\u2013158.2] min vs. 96 [90\u2013135.89] min), the difference was not statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.49). Blood transfusion was required in 4 patients in Group I and 1 patient in Group II. Intraoperative mean arterial pressure was significantly higher in Group II (110 \u00b1 13.3 mmHg vs. 101 \u00b1 13.7 mmHg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). Postoperative complications were comparable, with low rates of fever in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Vasopressin was more effective than misoprostol in reducing intraoperative blood loss and postoperative hemoglobin drop during laparoscopic myomectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/gmit.gmit-d-25-00083","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:00:29Z","timestamp":1784304029000},"page":"254-260","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Randomized Clinical Trial Comparing the Effect of Rectal Misoprostol with Intramyometrial Vasopressin on Blood Loss during Laparoscopic Myomectomy"],"prefix":"10.4103","volume":"15","author":[{"given":"Sangam","family":"Jha","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, AIIMS, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas Chandra","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, AIIMS, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharda","family":"Jha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, AIIMS, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"R2-20260720","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jmig.2007.01.013","article-title":"Italian multicenter study on complications of laparoscopic myomectomy","volume":"14","author":"Sizzi","year":"2007","journal-title":"J Minim 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