{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:07:38Z","timestamp":1784552858282,"version":"3.55.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women everywhere. PCOS without insulin resistance (IR) is much less severe than PCOS with IR, and the severity is less in the nonobese. Management and treatment of IR are imperative in PCOS management. As a major cause of female fertility issues, PCOS is yet to be fully understood. The symptoms of PCOS create a mental burden on the patient, which needs to be taken care of. Management of IR has significantly helped in reducing the symptoms of PCOS. Many studies have shown that there is no one solution to IR and PCOS. In this review, we examine the various pathophysiological processes, clinical impacts, and management of PCOS and IR. We also focus on how the combination of lifestyle changes, such as improving activity levels, consuming nutrient-rich whole foods, maintaining good mental health, quality sleep, pharmaceutical support and dietary supplements, is currently recognized as the management of IR and PCOS.<\/jats:p>","DOI":"10.4103\/gmit.gmit-d-25-00185","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:00:27Z","timestamp":1784304027000},"page":"199-206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Insulin Resistance in Polycystic Ovary Syndrome: Mechanistic Insights and Therapeutic Perspectives Independent of Obesity"],"prefix":"10.4103","volume":"15","author":[{"given":"Bethal","family":"Abhinethri","sequence":"first","affiliation":[{"name":"Department of Medical Writing, Innvocept Global Solutions Pvt. 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