{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:28:00Z","timestamp":1787761680795,"version":"build-2784847793"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"\n Objectives:<\/jats:title>\n Uterine fibroids and adenomyosis are common gynecological conditions that often require surgical treatment. Minimally invasive interventions such as ultrasound-guided high-intensity focused ultrasound (USgHIFU) are gaining popularity as they avoid surgical morbidity and conserve the uterus. We present a single-center experience on the use of USgHIFU for the treatment of fibroids and adenomyosis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This was a retrospective study of 167 patients who underwent USgHIFU for uterine fibroids and adenomyosis between July 2018 and December 2020. Relevant demographic data and pre- and post-intervention fibroid volume, symptom severity scores (SSS), and health-related quality of life (QOL) scores were collected and compared. The paired\n t<\/jats:italic>\n -test or Wilcoxon signed-rank test was used to compare the difference before and after treatment.\n P<\/jats:italic>\n < 0.001 was considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n One hundred and sixty-seven patients with fibroids or adenomyosis were included in this study. The mean age of the cohort was 42-year-old. USgHIFU treatment led to a reduction in mean fibroid volume, improvement in SSS, and health-related QOL scores. The average reduction in mean fibroid volume was 68% and 75% at 6 and 12 months, respectively. There was a significant reduction in SSS (46.9 [pre] vs. 15.6 [post],\n P<\/jats:italic>\n < 0.001) and improvement in health-related QOL scores at 6 months (58 [pre] vs. 86 [post],\n P<\/jats:italic>\n < 0.001). The re-intervention rate following USgHIFU was 7.7% and successful pregnancy post USgHIFU was reported in 6 patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n USgHIFU is safe and effective. In women who desire fertility or are not suitable for surgery, it is a good alternative option. It should be included in the armamentarium for the treatment of uterine fibroids and adenomyosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/gmit.gmit_102_22","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T01:52:16Z","timestamp":1675907536000},"page":"15-25","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["High-intensity Focused Ultrasound for the Treatment of Fibroids"],"prefix":"10.4103","volume":"12","author":[{"given":"Smita","family":"Jindal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KeenWhye","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20240830","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/01.grf.0000159538.27221.8c","article-title":"Role, epidemiology, and natural history of benign uterine mass lesions","volume":"48","author":"Ryan","year":"2005","journal-title":"Clin Obstet Gynecol"},{"key":"R2-4-20240830","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.fertnstert.2008.01.051","article-title":"Fibroids and infertility: An updated systematic review of the evidence","volume":"91","author":"Pritts","year":"2009","journal-title":"Fertil Steril"},{"key":"R3-4-20240830","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1177\/1933719111432867","article-title":"Medical treatment of uterine leiomyoma","volume":"19","author":"Sabry","year":"2012","journal-title":"Reprod Sci"},{"key":"R4-4-20240830","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/AOG.0b013e3182841594","article-title":"Complications of hysterectomy","volume":"121","author":"Clarke-Pearson","year":"2013","journal-title":"Obstet Gynecol"},{"key":"R5-4-20240830","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4103\/GMIT.GMIT_12_18","article-title":"Size, type, and location of myoma as predictors for successful laparoscopic myomectomy: A tertiary government hospital experience","volume":"7","author":"Martinez","year":"2018","journal-title":"Gynecol Minim Invasive Ther"},{"key":"R6-4-20240830","doi-asserted-by":"crossref","first-page":"6","DOI":"10.4103\/GMIT.GMIT_21_19","article-title":"The significant risk factors of intra-operative hemorrhage during laparoscopic myomectomy: A systematic review","volume":"9","author":"Sleiman","year":"2020","journal-title":"Gynecol Minim Invasive Ther"},{"key":"R7-4-20240830","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4103\/GMIT.GMIT_88_19","article-title":"Iatrogenic parasitic myoma with two recurrence times after subsequent myomectomy: A rare and complicated case report","volume":"9","author":"Li","year":"2020","journal-title":"Gynecol Minim Invasive Ther"},{"key":"R8-4-20240830","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/aogs.12920","article-title":"Trial of labor after myomectomy and uterine rupture: A systematic review","volume":"95","author":"Gambacorti-Passerini","year":"2016","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R9-4-20240830","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1085\/jgp.26.2.179","article-title":"A new method for the generation and use of focused ultrasound in experimental biology","volume":"26","author":"Lynn","year":"1942","journal-title":"J Gen Physiol"},{"key":"R10-4-20240830","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bpobgyn.2017.09.002","article-title":"High-intensity focused ultrasound therapy","volume":"46","author":"Cheung","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R11-4-20240830","doi-asserted-by":"crossref","first-page":"839","DOI":"10.3390\/jcm11030839","article-title":"Should ultrasound-guided high frequency focused ultrasound be considered as an alternative non-surgical treatment of uterine fibroids in non-Asiatic countries? 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