{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T15:42:06Z","timestamp":1792424526655,"version":"4.5.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:p>Cornual pregnancy (CP) is a subtype of ectopic pregnancy that is implanted in the interstitial segment of the fallopian tube which is defined as the tubal section crossing uterine muscular tissue. Widely recognized risk factors for CP are endometriosis, uterine leiomyomata, or pelvic inflammatory disease; all these diseases can cause tubal anatomic changes and consequently alter embryo physiological implant process. Many treatment options are available for this condition each one must be tailored according to patient and operating scenario. The incidence of uterine ruptures in the scarred uterus appears to be low, but the fear of it remains and therefore medical treatment might be favored over cornual wedge resection. The actual risk of uterine rupture after medical treatment is unknown. Multiple testing strategies exist to diagnose CP, but caution needs to be used to avoid a false diagnosis.<\/jats:p>","DOI":"10.4103\/gmit.gmit_10_23","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T09:23:46Z","timestamp":1691659426000},"page":"130-134","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":29,"title":["Cornual Pregnancy"],"prefix":"10.4103","volume":"12","author":[{"given":"Maria","family":"Gaetani","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Di Gennaro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Vimercati","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amerigo","family":"Vitagliano","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Dellino","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Malvasi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Loizzi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore","family":"Cicinelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Di Naro","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Lacalandra","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca Raffaello","family":"Damiani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic, University of Bari, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ajog.2009.07.054","article-title":"Current diagnosis and treatment of interstitial pregnancy","volume":"202","author":"Moawad","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1576\/toag.9.4.249.27355","article-title":"Management of cornual (interstitial) pregnancy","volume":"9","author":"Radwan","year":"2007","journal-title":"Obstet Gynaecol"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ijsu.2018.03.025","article-title":"Laparoscopic treatment of cornual heterotopic pregnancy:A retrospective cohort study","volume":"53","author":"Xu","year":"2018","journal-title":"Int J Surg"},{"key":"R4-20240830","first-page":"105","article-title":"Angular pregnancy:A review of cases reported in the past 80 years","volume":"1","author":"Rankin","year":"2014","journal-title":"Gynecol Case Rev"},{"key":"R5-20240830","first-page":"702","article-title":"Angular pregnancy:An eccentric implantation within uterine cavity","volume":"33","author":"Mustafa","year":"2021","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"R6-20240830","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s13304-020-00778-7","article-title":"Extra-uterine bilateral tubal ectopic pregnancy","volume":"72","author":"Damiani","year":"2020","journal-title":"Updates Surg"},{"key":"R7-20240830","first-page":"423","article-title":"Unilateral twin tubal pregnancy:A case report and review of the literature","volume":"89","author":"Betti","year":"2018","journal-title":"Acta Biomed"},{"key":"R8-20240830","first-page":"550","article-title":"Cornual pregnancy after surgical treatment of an incarcerated fallopian tube:A case report","volume":"58","author":"Damiani","year":"2013","journal-title":"J Reprod Med"},{"key":"R9-20240830","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1055\/s-0043-100107","article-title":"Recurrent interstitial pregnancy:A review of the literature","volume":"77","author":"Egger","year":"2017","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"R10-20240830","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1503\/cmaj.050222","article-title":"Diagnosis and treatment of ectopic pregnancy","volume":"173","author":"Murray","year":"2005","journal-title":"CMAJ"},{"key":"R11-20240830","doi-asserted-by":"crossref","first-page":"262","DOI":"10.31083\/j.ceog4912262","article-title":"Ectopic pregnancy:An overview","volume":"49","author":"Di Gennaro","year":"2022","journal-title":"Clin Exp Obstet Gynecol"},{"key":"R12-20240830","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.fertnstert.2011.10.037","article-title":"Performance of human chorionic gonadotropin curves in women at risk for ectopic pregnancy:Exceptions to the rules","volume":"97","author":"Morse","year":"2012","journal-title":"Fertil Steril"},{"key":"R13-20240830","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/01.AOG.0000128174.48843.12","article-title":"Symptomatic patients with an early viable intrauterine pregnancy:HCG curves redefined","volume":"104","author":"Barnhart","year":"2004","journal-title":"Obstet Gynecol"},{"key":"R14-20240830","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jogc.2017.03.087","article-title":"Can the presence of a surrounding endometrium differentiate eccentrically located intrauterine pregnancy from interstitial ectopic pregnancy?","volume":"39","author":"Grant","year":"2017","journal-title":"J Obstet Gynaecol Can"},{"key":"R15-20240830","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00404-016-4069-y","article-title":"Non-tubal ectopic pregnancy","volume":"294","author":"Parker","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"R16-20240830","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.tjog.2020.11.028","article-title":"Interstitial ectopic pregnancy:A more confident diagnosis with three-dimensional sonography","volume":"60","author":"Lin","year":"2021","journal-title":"Taiwan J Obstet Gynecol"},{"key":"R17-20240830","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12884-022-04470-z","article-title":"The role of three-dimensional MRI in the differentiation between angular pregnancy and interstitial pregnancy","volume":"22","author":"Gao","year":"2022","journal-title":"BMC Pregnancy Childbirth"},{"key":"R19-20240830","first-page":"e9642","article-title":"Methotrexate for cornual ectopic pregnancy","volume":"12","author":"Parker","year":"2020","journal-title":"Cureus"},{"key":"R20-20240830","first-page":"e15","article-title":"Diagnosis and management of ectopic pregnancy","volume":"123","author":"Elson","year":"2016","journal-title":"BJOG"},{"key":"R21-20240830","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/01443615.2013.789834","article-title":"Pivotal points in interstitial pregnancy:New insights in conservative medical treatment of non-ruptured interstitial pregnancy","volume":"34","author":"Pellegrino","year":"2014","journal-title":"J Obstet Gynaecol"},{"key":"R22-20240830","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5603\/GP.2020.0071","article-title":"The role of day 0 and day 4 \u03b2-human chorionic gonadotropin values and initial ultrasound findings in predicting the success of methotrexate treatment in ectopic pregnancy","volume":"91","author":"Tasgoz","year":"2020","journal-title":"Ginekol Pol"},{"key":"R23-20240830","first-page":"1193","article-title":"Surgical management of interstitial (cornual) ectopic pregnancy:Many ways to peel an orange!Fertil Steril","volume":"115","author":"Bhagavath","year":"2021"},{"key":"R24-20240830","doi-asserted-by":"crossref","first-page":"73","DOI":"10.52054\/FVVO.13.1.009","article-title":"Methotrexate injection for interstitial pregnancy:Hysteroscopic conservative mini-invasive approach","volume":"13","author":"Casadio","year":"2021","journal-title":"Facts Views Vis Obgyn"},{"key":"R25-20240830","doi-asserted-by":"crossref","first-page":"bcr2017223998","DOI":"10.1136\/bcr-2017-223998","article-title":"Cornual ectopic pregnancy:Laparoscopic management step by step","volume":"2018","author":"Varun","year":"2018","journal-title":"BMJ Case Rep"},{"key":"R26-20240830","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.fertnstert.2021.05.082","article-title":"Hysteroscopy-assisted laparoscopic salpingectomy for interstitial pregnancy without cornual resection","volume":"116","author":"Nezhat","year":"2021","journal-title":"Fertil Steril"},{"key":"R27-20240830","first-page":"167","article-title":"Interstitial pregnancy:Cornuostomy or wedge resection?J Chin Med Assoc","volume":"82","author":"Jiang","year":"2019"},{"key":"R28-20240830","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/ajo.12497","article-title":"Cornual wedge resection for interstitial pregnancy and postoperative outcome","volume":"57","author":"Liao","year":"2017","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"R29-20240830","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1080\/09513590.2020.1716328","article-title":"Laparoscopic management of a cornual pregnancy following failed methotrexate treatment:Case report and review of literature","volume":"36","author":"Tinelli","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"R30-20240830","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jmig.2021.11.004","article-title":"Cornual pregnancy","volume":"29","author":"Biffi","year":"2022","journal-title":"J Minim Invasive Gynecol"},{"key":"R31-20240830","first-page":"e19280","article-title":"Large interstitial ectopic pregnancy:Management by laparoscopic cornuostomy following initial misdiagnosis","volume":"13","author":"Mittal","year":"2021","journal-title":"Cureus"},{"key":"R32-20240830","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4293\/108680813X13753907292836","article-title":"Interstitial ectopic pregnancy:Conservative surgical management","volume":"18","author":"Warda","year":"2014","journal-title":"JSLS"},{"key":"R33-20240830","first-page":"e14249","article-title":"Use of the purse-string suture to conservatively manage a cornual ectopic pregnancy","volume":"13","author":"Oshodi","year":"2021","journal-title":"Cureus"},{"key":"R34-20240830","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/ijgo.13271","article-title":"Abdominal pregnancy during the COVID-19 pandemic","volume":"150","author":"Damiani","year":"2020","journal-title":"Int J Gynaecol Obstet"}],"container-title":["Gynecology and Minimally Invasive Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/gmit.gmit_10_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:53:49Z","timestamp":1787756029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/gmit.gmit_10_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/gmit.gmit_10_23","relation":{},"ISSN":["2213-3070","2213-3089"],"issn-type":[{"value":"2213-3070","type":"print"},{"value":"2213-3089","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2023-02-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}