{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:22:56Z","timestamp":1787844176849,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>We present a patient diagnosed with high-grade cervical intraepithelial neoplasia (CIN) combined with macroscopic lesions of the vaginal epithelium. There was no lesion in pelvic magnetic resonance imaging examination, and histopathological examination revealed CIN3 and vaginal intraepithelial neoplasia (VAIN) 3 without invasion. We chose minimally invasive surgery for her and total laparoscopic hysterectomy with partial resection of the vagina was carried out. To determine appropriate surgical margins, vaginal colpotomy was performed. No recurrence of VAIN has been observed to date that passed for 9 months either.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/gmit.gmit_119_19","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T07:44:14Z","timestamp":1619768654000},"page":"124-126","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Successful Endoscopic Treatment for High-grade Cervical Intraepithelial Neoplasia with Gross Lesions of the Vagina"],"prefix":"10.4103","volume":"10","author":[{"given":"Koyo","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miho","family":"Kitai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasumi","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Sakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Nagao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20240830","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(08)70103-7","article-title":"Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: A retrospective cohort study","volume":"9","author":"McCredie","year":"2008","journal-title":"Lancet Oncol"},{"key":"R2-11-20240830","doi-asserted-by":"crossref","first-page":"113.e1","DOI":"10.1016\/j.ajog.2008.02.026","article-title":"Incidence of vaginal intraepithelial neoplasia after hysterectomy for cervical intraepithelial neoplasia: A retrospective study","volume":"199","author":"Schockaert","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"R3-11-20240830","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1006\/gyno.2001.6401","article-title":"Clinical features and risk of recurrence among patients with vaginal intraepithelial neoplasia","volume":"83","author":"Dodge","year":"2001","journal-title":"Gynecol Oncol"},{"key":"R4-11-20240830","doi-asserted-by":"crossref","first-page":"e0167386","DOI":"10.1371\/journal.pone.0167386","article-title":"Detection of human papillomavirus infection in patients with vaginal intraepithelial neoplasia","volume":"11","author":"Lamos","year":"2016","journal-title":"PLoS One"},{"key":"R5-11-20240830","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/AOG.0b013e31819bd6e0","article-title":"Human papillomavirus type-distribution in vulvar and vaginal cancers and their associated precursors","volume":"113","author":"Smith","year":"2009","journal-title":"Obstet Gynecol"},{"key":"R6-11-20240830","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/jnci\/93.4.315","article-title":"Human papillomavirus type 16 variants and risk of cervical cancer","volume":"93","author":"Hildesheim","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"R7-11-20240830","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/jnci\/92.9.709","article-title":"Evidence for a causal association between human papillomavirus and a subset of head and neck cancers","volume":"92","author":"Gillison","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"R8-11-20240830","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/jnci\/87.11.796","article-title":"Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. International Biological Study on Cervical Cancer (IBSCC) Study Group","volume":"87","author":"Bosch","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"R9-11-20240830","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/jnci\/85.1.19","article-title":"History of circumcision, medical conditions, and sexual activity and risk of penile cancer","volume":"85","author":"Maden","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"R10-11-20240830","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1056\/NEJMoa061760","article-title":"Quadrivalent vaccine against human papillomavirus to prevent anogenital diseases","volume":"356","author":"Garland","year":"2007","journal-title":"N Engl J Med"}],"container-title":["Gynecology and Minimally Invasive Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/GMIT.GMIT_119_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:13:12Z","timestamp":1787843592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/GMIT.GMIT_119_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/gmit.gmit_119_19","relation":{},"ISSN":["2213-3070"],"issn-type":[{"value":"2213-3070","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}