{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:22:38Z","timestamp":1787757758551,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The objective was to investigate the microscopic artifacts made in the uterus of cervical high-grade squamous intraepithelial lesion (HSIL) resected by hysterectomy through minimally invasive (H-MI) procedures and to verify whether these specimens are suitable for histopathological assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This single-center retrospective study analyzed 28 patients with cervical HSIL, consisting of 21 premenopausal and seven postmenopausal women, who underwent H-MI. The proportion of the cervical mucosa covered by intact surface epithelium (residual ratio [RR]) was measured on microscopically. Surgical margin\u2019s status was also verified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All cases developed detachment of the cervical surface epithelium to a varying extent. The RR was significantly higher in the premenopausal patients (median: 75.5%) than in the postmenopausal patients (median: 37.6%). Among the premenopausal patients, the RR was lower in the cases on whom uterine manipulator (UM) was used (median: 70.5%) than in the cases without UM use (median 92.7%). Among the 21 cases whose resected uterus contained HSIL, the vaginal resection margin was not assessable in three (14.2%) of the seven postmenopausal cases due to the artifact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although transvaginal manipulation of the uterus causes detachment of the cervical surface epithelium, H-MI for cervical HSIL provides an acceptable specimen for histological assessment in premenopausal patients, even if UM is used. In postmenopausal women, H-MI easily develops artifactual loss of cervical surface epithelium, sometimes providing an unfavorable specimen for microscopic assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/gmit.gmit_68_22","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T09:23:46Z","timestamp":1691659426000},"page":"148-152","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Hysterectomy through Minimally Invasive Surgery for Cervical High-grade Intraepithelial Neoplasia: Reassessment of the Specimens\u2019 Eligibility for Histological Examination"],"prefix":"10.4103","volume":"12","author":[{"given":"Shuichi","family":"Kurihara","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka Hospital, Ogusu, Minami-Ku, Fukuoka, Japan"},{"name":"Department of Obstetrics and Gynecology, Japanese Red Cross Matsuyama Hospital, Matsuyama, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichiro","family":"Hamasaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka Hospital, Ogusu, Minami-Ku, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachiko","family":"Onjo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka Hospital, Ogusu, Minami-Ku, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Pathology, Japanese Red Cross Fukuoka Hospital, Ogusu, Minami-Ku, Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Japanese Red Cross Fukuoka 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