{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:37:51Z","timestamp":1787841471796,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Invasive hydatidiform mole, a form of gestational trophoblastic neoplasm in reproductive-age women, poses a significant threat to life due to its associated signs and symptoms. This case report details the management of a 24-year-old Chinese woman with no prior pregnancy history, who presented at our hospital 23 days postcurettage, experiencing persistent vaginal bleeding for 3 days. While two rounds of chemotherapy effectively reduced human chorionic gonadotropin levels, a subsequent magnetic resonance imaging (MRI) revealed suspicious growth lesions in the uterus. High-intensity focused ultrasound (HIFU) treatment was administered under ultrasound guidance, resulting in notable grayscale changes to optimize the efficacy of chemotherapy and restrict lesion progression. Subsequent ultrasound and MRI assessments during follow-up demonstrated a transparent texture in the muscle layer at the lesion site. This case suggests that the combination of chemotherapy and HIFU, guided by ultrasound, may represent a promising therapeutic approach for managing invasive hydatidiform mole.<\/jats:p>","DOI":"10.4103\/gmit.gmit_86_23","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T07:03:39Z","timestamp":1721372619000},"page":"184-188","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Integrating High-intensity Focused Ultrasound with Chemotherapy for the Treatment of Invasive Hydatidiform Mole in Reproductive-age Women"],"prefix":"10.4103","volume":"13","author":[{"given":"Yongmiao","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hangzhou Women\u2019s Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiqing","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hangzhou Red Cross Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hangzhou Women\u2019s Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Hangzhou Women\u2019s Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjun","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hangzhou Women\u2019s Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Hangzhou Women\u2019s Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gynecological, Chengdu Focused Ultrasound Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Gynecological, Chengdu Focused Ultrasound Hospital, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"issue":"Suppl 6","key":"R1-20240830","doi-asserted-by":"crossref","first-page":"i39","DOI":"10.1093\/annonc\/mdt345","article-title":"Gestational trophoblastic disease: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"24","author":"Seckl","year":"2013","journal-title":"Ann Oncol"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bpobgyn.2020.12.001","article-title":"Clinical presentation and diagnosis of gestational trophoblastic disease","volume":"74","author":"Lok","year":"2021","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.6004\/jnccn.2019.0053","article-title":"Gestational trophoblastic neoplasia, version 2.2019, NCCN clinical practice guidelines in oncology","volume":"17","author":"Abu-Rustum","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0020-7292(02)00063-2","article-title":"FIGO staging for gestational trophoblastic neoplasia 2000. 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