{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:39:43Z","timestamp":1786649983944,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Heart failure with reduced ejection fraction (HFrEF) in Qatar has not been well characterized in the outpatient setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To describe the characteristics of patients with HFrEF who had improvement in their left ventricular ejection fraction (LVEF) and independent predictors of improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study conducted at the advanced heart failure (HF) clinic in Qatar recruited patients who visited the clinic between January 2017 and December 2018. Adult patients were eligible if they were diagnosed with HFrEF (LVEF &lt; 40%) and had two echocardiograms separated by at least 6 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Of 582 eligible patients, 161 (27.7%) had improved LVEF. They were younger (53.4 vs. 57.3 years,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002) and had shorter duration of HF diagnosis (4.3 vs. 5.6 years,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). They experienced lower rates of all-cause hospitalization (20.5% vs. 38.0%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001) and emergency department visits (25.5% vs. 35.9%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), without a difference in hospital mortality rate, than those without LVEF improvement. Decreased odds ratio of improved LVEF was associated with per year increase in age (adjusted odds ratio [aOR]: 0.98, 95% confidence interval [CI]: 0.97\u20130.99,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03), presence of left bundle branch block (aOR: 0.40, 95% CI: 0.20\u20130.80,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), duration of HF diagnosis (aOR: 0.85, 95% CI: 0.78\u20130.94,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001), and ischemic HF etiology (aOR: 0.50, 95% CI: 0.30\u20130.77,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001; compared with dilated etiology). Beta-blocker therapy was associated with higher odds of LVEF improvement (aOR: 2.65, 95% CI: 1.02\u20136.88,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Patients with HFrEF with improved LVEF were younger, had a nonischemic cardiomyopathy, and had significantly fewer hospitalizations and emergency department visits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/heartviews.heartviews_34_24","type":"journal-article","created":{"date-parts":[[2025,1,4]],"date-time":"2025-01-04T09:00:20Z","timestamp":1735981220000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Characteristics and Outcomes of Heart Failure Outpatients with Improvement in Ejection Fraction in Qatar"],"prefix":"10.4103","volume":"25","author":[{"given":"Rasha","family":"Kaddoura","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jassim Zaheen","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Izham Mohamed","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, QU Health, Qatar University, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajvir","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ammar","family":"Chapra","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisam","family":"Alsadi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha Al","family":"Amri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahseen","family":"Hamamyh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar","family":"Fallouh","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farras","family":"Elasad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Salah","family":"Abdelghani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumaya Alsaadi","family":"Alyafei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Badr","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashfaq","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Heart Hospital, Hamad Medical Corporation, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,4]]},"reference":[{"key":"R1-20260423","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cardfail.2021.01.022","article-title":"Universal definition and classification of heart failure","volume":"27","author":"Bozkurt","year":"2021","journal-title":"J Card Fail"},{"key":"R2-20260423","doi-asserted-by":"crossref","first-page":"e011077","DOI":"10.1161\/JAHA.118.011077","article-title":"Characteristics, outcomes, and treatment of 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History"}},{"value":"2024-08-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}