{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:30:56Z","timestamp":1787758256512,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"\n Background:<\/jats:title>\n Coronary artery bypass grafting is the standard of care for patients with obstructive left main (LM) coronary disease. In poor surgical candidates, high-risk percutaneous coronary artery intervention (PCI) is an alternative.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n We investigated a retrospective cohort of patients who underwent LM PCI from January 2010 to March 2014 (\n n<\/jats:italic>\n = 89). Obstructive LM disease was defined as 50% angiographic obstruction of luminal flow, and the primary endpoint was inhospital mortality. Ventricular assist device (VAD) was defined as the use of either intra-aortic balloon pump (IABP) or Impella 2.5 devices before, during, or following PCI.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 89 patients with LM PCI were divided into those with (\n n<\/jats:italic>\n = 39) and without (\n n<\/jats:italic>\n = 50) VAD support. The former group was further divided into those with support from either Impella 2.5 (\n n<\/jats:italic>\n = 28) or IABP (\n n<\/jats:italic>\n = 11). Age, race, and gender did not differ between patients who received unassisted LM-PCI from those with VAD support (\n P<\/jats:italic>\n = 0.142, 1.0, and 0.776, respectively). The angiographic stenosis of atherosclerotic lesions in LM, proximal left anterior descending artery, and other native\/surgical coronary vessels was similar between the groups. The duration of hospitalization was significantly longer for patients with VAD support compared to those without (7.19 \u00b1 6.89 vs. 2.78 \u00b1 3.39,\n P<\/jats:italic>\n < 0.001). The incidence of cardiogenic shock and inhospital mortality was significantly higher in the VAD group (\n P<\/jats:italic>\n = 0.009 and 0.001, respectively). Overall, inhospital mortality was 9% (8\/89). The IABP and Impella 2.5 groups had mortality proportions of 46% (5\/11) and 11% (3\/28), respectively;\n P<\/jats:italic>\n = 0.028. For all patients, inhospital mortality was higher for those with versus without cardiogenic shock (56% or 5\/9 vs. 4% or 3\/80;\n P<\/jats:italic>\n < 0.001), and for those with versus without left ventricular systolic function <40% (17% vs. 2%;\n P<\/jats:italic>\n < 0.025).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In a selected group of patients with LM disease, unsupported PCI appears to be a feasible and safe procedure. In high-risk patients, the use of Impella 2.5 appears to be superior to IABP in LM PCI resulting in favorable short-term outcomes.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/heartviews.heartviews_6_22","type":"journal-article","created":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T14:23:08Z","timestamp":1666448588000},"page":"150-156","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Left Ventricular Support for Unprotected Left Main Coronary Artery Interventions (The Dayton Heart and Vascular Impella Registry)"],"prefix":"10.4103","volume":"23","author":[{"given":"Ali Abdul","family":"Jabbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaser","family":"Jbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali J.","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Mufti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omair","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Markert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Joffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Fishbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240902","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/01.CIR.79.6.1171","article-title":"Asymptomatic left main coronary artery disease in the Coronary Artery Surgery Study (CASS) 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