{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:38:03Z","timestamp":1786653483824,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The study aimed to evaluate the clinical outcome and complications after thrombolysis in patients with left-sided prosthetic valve thrombosis (PVT) in relation to the time of onset of symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This was a prospective, observational, single-center study carried out from January 2020 to June 2022 at a tertiary care center in India. A total of 50 patients with PVT were included in the study. Patients underwent thrombolysis either with streptokinase or tenecteplase as per their individual clinical status. Clinical profile and treatment outcomes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PVT was more in females (64%) as compared to males (36%). The majority of the patients were in the age group of 31\u201340 years (38%) with a mean age of presentation being 32.7 years. Majority of the patients (39 patients) had symptom onset between 0 and 7 days (78%) while 11 patients (22%) presented beyond 7 days. Streptokinase was used for thrombolysis in 37 patients while Tenecteplase was used in 13 patients. In our study, majority of the patients 30 (60%) had a complete response to thrombolysis while 10 (20%) patients had a partial response, and no response to thrombolysis was seen in 10 (20%) patients. Hemorrhagic stroke was seen in 4 (8%) patients. Among 6 deaths, 3 were due to hemorrhagic stroke and 3 were due to cardiogenic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Early thrombolysis within 7 days of symptom onset provides a good response to thrombolysis after which the response to thrombolysis is more likely to be suboptimal.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/heartviews.heartviews_98_24","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:00:20Z","timestamp":1759341620000},"page":"96-101","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Time to Thrombolysis and Outcomes in Patients with Left-sided Prosthetic Valve Thrombosis: Is Thrombolysis Worth Beyond 7 Days?"],"prefix":"10.4103","volume":"26","author":[{"given":"Vatsal","family":"Kayal","sequence":"first","affiliation":[{"name":"Department of Cardiology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhagya Narayan","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit Kumar","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh Kumar","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Cardiology, LPS Institute of Cardiology, Kanpur, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dheerendra","family":"Kuber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, ABVIMS and Dr. RML Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"R2-20251007","first-page":"214","article-title":"Thrombolysis for left-sided prosthetic valve thrombosis: Short- and long-term outcomes","volume":"25","author":"Gupta","year":"2016","journal-title":"J Heart Valve Dis"},{"key":"R3-20251007","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13019-020-01324-7","article-title":"Thrombolytic treatment of prosthetic valve thrombosis: A study using Urokinase","volume":"15","author":"Huang","year":"2020","journal-title":"J Cardiothorac Surg"},{"key":"R4-20251007","first-page":"196","article-title":"Valve thrombosis and thrombolytic therapy in modern era: A case report","volume":"2","author":"Aguilar-Molina","year":"2021","journal-title":"Arch Peru Cardiol Cir Cardiovasc"},{"key":"R5-20251007","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0002-9149(93)90740-4","article-title":"Comparison of transthoracic and transesophageal echocardiography for detection of abnormalities of prosthetic and bioprosthetic valves in the mitral and aortic positions","volume":"71","author":"Daniel","year":"1993","journal-title":"Am J Cardiol"},{"key":"R6-20251007","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jcmg.2012.10.016","article-title":"Comparison of different TEE-guided thrombolytic regimens for prosthetic valve thrombosis: The TROIA trial","volume":"6","author":"\u00d6zkan","year":"2013","journal-title":"JACC Cardiovasc 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treated with streptokinase or tenecteplase","volume":"73","author":"Kiran","year":"2021","journal-title":"Indian Heart J"},{"key":"R14-20251007","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/jocs.12510","article-title":"Prosthetic valve thrombosis","volume":"30","author":"Separham","year":"2015","journal-title":"J Card Surg"},{"key":"R15-20251007","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S0735-1097(02)02871-1","article-title":"The thrombosed prosthetic valve: Current recommendations based on evidence from the literature","volume":"41","author":"Alpert","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"R16-20251007","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.18203\/2320-6012.ijrms20191079","article-title":"Study of prosthetic heart valve thrombosis and outcomes after thrombolysis","volume":"7","author":"Patil","year":"2019","journal-title":"Int J Res Med 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Consensus conference on prosthetic valve thrombosis","volume":"30","author":"Lengyel","year":"1997","journal-title":"J Am Coll Cardiol"}],"container-title":["Heart Views"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/heartviews.heartviews_98_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:38:07Z","timestamp":1786649887000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/heartviews.heartviews_98_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/heartviews.heartviews_98_24","relation":{},"ISSN":["1995-705X","0976-5123"],"issn-type":[{"value":"1995-705X","type":"print"},{"value":"0976-5123","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-08-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}