{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:25:28Z","timestamp":1787775928514,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>Acquired factor XIII (FXIII) deficiency is a rare disorder that could be associated with autoimmune and malignant disorders with a high risk of bleeding. In acute leukemias, acquired FXIII deficiency has been reported and replacement of FXIII helped to control significant bleeding. Here, we report four cases of myeloid neoplasms to have acquired FXIII deficiency with interesting concomitant RUNX1 mutation in the molecular background of two patients. Correction of bleeding complications was successful in all patients with FXIII substitution by FXIII concentrate in three patients and cryoprecipitate in one patient. Studying the association of FXIII deficiency with molecular abnormalities in such neoplasms is needed for better understanding and detection of common pathophysiologic pathways. This could help to avoid severe bleeding during diagnostic or therapeutic interventions in patients at risk.<\/jats:p>","DOI":"10.4103\/hemoncstem.hemoncstem-d-24-00034","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T03:00:11Z","timestamp":1737342011000},"page":"245-247","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Acquired factor XIII deficiency in myeloid neoplasms: case series and review of literature"],"prefix":"10.4103","volume":"17","author":[{"given":"Alfadil","family":"Haroon","sequence":"first","affiliation":[{"name":"Adult Hematology, Stem Cell Transplant and Cellular Therapy Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa F","family":"Mohammed Saleh","sequence":"additional","affiliation":[{"name":"Adult Hematology, Stem Cell Transplant and Cellular Therapy Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"},{"name":"Clinical Hematology Unit, Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alahmari","sequence":"additional","affiliation":[{"name":"Adult Hematology, Stem Cell Transplant and Cellular Therapy Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed","family":"Osman","sequence":"additional","affiliation":[{"name":"Adult Hematology, Stem Cell Transplant and Cellular Therapy Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Adult Hematology, Stem Cell Transplant and Cellular Therapy Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazzaa","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Adult Hematology, Stem Cell Transplant and Cellular Therapy Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Aljurf","sequence":"additional","affiliation":[{"name":"Adult Hematology, Stem Cell Transplant and Cellular Therapy Section, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"R1-20250123","doi-asserted-by":"crossref","first-page":"160","DOI":"10.5482\/HAMO-13-08-0046","article-title":"Coagulation factor XIII deficiency. Diagnosis, prevalence and management of inherited and acquired forms","volume":"34","author":"Biswas","year":"2014","journal-title":"Hamostaseologie"},{"key":"R2-20250123","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.transci.2018.10.013","article-title":"Acquired factor XIII deficiency: a review","volume":"57","author":"Yan","year":"2018","journal-title":"Transf Apheresis Sci"},{"key":"R3-20250123","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ijlh.12756","article-title":"Factor XIII deficiency diagnosis: challenges and tools","volume":"40","author":"Karimi","year":"2018","journal-title":"Int J Lab Hematol"},{"key":"R4-20250123","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1160\/TH12-08-0604","article-title":"Acquired factor XIII deficiency: a therapeutic challenge","volume":"109","author":"Boehlen","year":"2013","journal-title":"Thromb Haemost"},{"key":"R5-20250123","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1182\/blood.V124.21.1528.1528","article-title":"Factor XIII deficiency in patients with acute leukemia: one out of three is presenting with deficiency","volume":"124","author":"Vagge","year":"2014","journal-title":"Blood"},{"key":"R6-20250123","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.3324\/haematol.2013.089045","article-title":"Hyperfibrinolysis and acquired factor XIII deficiency in newly diagnosed pediatric malignancies","volume":"98","author":"Wiegering","year":"2013","journal-title":"Haematologica"},{"key":"R7-20250123","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1182\/blood-2020-141382","article-title":"Transcription factor RUNX1 regulates factor FXIIIA subunit (F13A1) expression in megakaryocytic cells and platelet F13A1 expression is downregulated in RUNX1 haplodeficiency","volume":"136","author":"Songdej","year":"2020","journal-title":"Blood"},{"key":"R8-20250123","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/BF01651269","article-title":"Factor XIII deficiency in adults with acute leukemia: results of a substitution therapy with factor XIII (author\u2019s transl)","volume":"55","author":"Havemann","year":"1977","journal-title":"Klin Wochenschr"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/hemoncstem.hemoncstem-D-24-00034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:46:23Z","timestamp":1787773583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/hemoncstem.hemoncstem-D-24-00034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/hemoncstem.hemoncstem-d-24-00034","relation":{},"ISSN":["1658-3876","2589-0646"],"issn-type":[{"value":"1658-3876","type":"print"},{"value":"2589-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2024-08-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}