{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:43:00Z","timestamp":1787071380986,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background<\/jats:title>\n Acute respiratory failure (ARF) is common in lung cancer patients and could be related to tumor progression, effects of treatment, or comorbid illnesses. Data on the short-term outcomes of these patients, especially those requiring invasive mechanical ventilation (IMV), remain scarce.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The National Inpatient Sample database (2016\u20132019) was used to identify lung cancer admissions using International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10-CM) codes. ARF and IMV subgroups within lung cancer hospitalizations were identified using ICD-10-CM codes. Baseline variables were analyzed using\n \u03c7<\/jats:italic>\n 2<\/jats:sup>\n test for categorical data and adjusted Wald tests for continuous data. Results were reported as percentages and mean\u2009\u00b1\u2009standard deviation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We identified 581,805 (24.7%) admissions for lung cancer with ARF during the study period. All-cause inpatient mortality was six times higher in lung cancer admissions with ARF compared to the non-ARF cohort (18.50% vs. 3.19%;\n P<\/jats:italic>\n < 0.001). Similarly, lung cancer admissions with ARF that required IMV had significantly higher mortality compared to the cohort that did not require IMV (44.86% vs. 12.59%;\n P<\/jats:italic>\n < 0.001). Lung cancer admissions with ARF requiring IMV had longer stay in the hospital (11.19 vs. 6.69 days;\n P<\/jats:italic>\n < 0.001). The total hospitalization cost was more than two times higher for lung cancer admissions with ARF requiring IMV ($40,024.2 vs. $16,260.5;\n P<\/jats:italic>\n < 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n In this largest study to date, we provide insight into the incidence and outcomes of lung cancer admissions with ARF. Lung cancer admissions with ARF, especially those requiring IMV, were associated with worse outcomes, longer hospital stays, and significantly higher healthcare costs. Compared to historical data, the outcomes in this large database have improved.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/hemoncstem.hemoncstem-d-25-00025","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T09:00:07Z","timestamp":1757667607000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology and outcomes of hospitalized patients with lung cancer and acute respiratory failure: National inpatient database analysis"],"prefix":"10.4103","author":[{"given":"Martina","family":"Tripcovici","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittni J.","family":"Clopton","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman O.","family":"Soubani","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,12]]},"reference":[{"key":"R1-20250912","doi-asserted-by":"crossref","first-page":"836","DOI":"10.21037\/atm-21-298","article-title":"Clinical outcomes in patients with lung cancer admitted to intensive care units","volume":"9","author":"Park","year":"2021","journal-title":"Ann Transl Med"},{"key":"R2-20250912","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/annonc\/mdu234","article-title":"Lung Cancer in Critical Care (LUCCA) Study Investigators. Intensive care in patients with lung cancer: a multinational study","volume":"25","author":"Soares","year":"2014","journal-title":"Ann Oncol"},{"key":"R3-20250912","first-page":"60","article-title":"Outcome of lung cancer patients admitted to the intensive care unit with acute respiratory failure","volume":"17","author":"Anisoglou","year":"2013","journal-title":"Hippokratia"},{"key":"R4-20250912","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1002\/cncr.35128","article-title":"Lung cancer statistics, 2023","volume":"130","author":"Kratzer","year":"2024","journal-title":"Cancer"},{"key":"R5-20250912","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"R6-20250912","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1056\/NEJMoa1916623","article-title":"The effect of advances in lung-cancer treatment on population mortality","volume":"383","author":"Howlader","year":"2020","journal-title":"N Engl J Med"},{"key":"R7-20250912","doi-asserted-by":"crossref","first-page":"e069008","DOI":"10.1136\/bmj-2021-069008","article-title":"Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study","volume":"376","author":"Potter","year":"2022","journal-title":"BMJ"},{"key":"R8-20250912","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1378\/chest.14-0477","article-title":"Aggressiveness of intensive care use among patients with lung cancer in the Surveillance, Epidemiology, and End Results-Medicare registry","volume":"146","author":"Cooke","year":"2014","journal-title":"Chest"},{"key":"R9-20250912","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/JTO.0b013e318200f9eb","article-title":"The outcome of medical intensive care for lung cancer patients: the case for optimism","volume":"6","author":"Soubani","year":"2011","journal-title":"J Thorac Oncol"},{"key":"R10-20250912","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1001\/jama.1986.03380240058028","article-title":"Outcome of lung cancer patients requiring mechanical ventilation for pulmonary failure","volume":"256","author":"Ewer","year":"1986","journal-title":"JAMA"},{"key":"R11-20250912","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.rmed.2003.07.009","article-title":"Outcome of lung cancer patients with acute respiratory failure requiring mechanical ventilation","volume":"98","author":"Lin","year":"2004","journal-title":"Respir Med"},{"key":"R12-20250912","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.medin.2021.08.005","article-title":"Determinants of mortality in cancer patients with unscheduled admission to the intensive care unit: a prospective multicenter study","volume":"46","author":"Canton-Bulnes","year":"2022","journal-title":"Med Intensiva (Engl Ed)"},{"key":"R13-20250912","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1378\/chest.13-1870","article-title":"Brazilian Research in Intensive Care Network (BRICNet). Outcomes for patients with cancer admitted to the ICU requiring ventilatory support: results from a prospective multicenter study","volume":"146","author":"Azevedo","year":"2014","journal-title":"Chest"},{"key":"R14-20250912","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1378\/chest.06-2244","article-title":"Prognosis of lung cancer patients with life-threatening complications","volume":"131","author":"Soares","year":"2007","journal-title":"Chest"},{"key":"R15-20250912","first-page":"2945","article-title":"Performance status (PS): a simple predictor of short-term outcome of cancer patients with solid tumors admitted to the intensive care unit (ICU)","volume":"27","author":"Christodoulou","year":"2007","journal-title":"Anticancer Res"},{"key":"R16-20250912","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s001340000701","article-title":"Predictive factors of death in primary lung cancer patients on admission to the intensive care unit","volume":"26","author":"Boussat","year":"2000","journal-title":"Intensive Care Med"},{"key":"R17-20250912","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00003246-200103000-00009","article-title":"Improved survival in cancer patients requiring mechanical ventilatory support: impact of noninvasive mechanical ventilatory support","volume":"29","author":"Azoulay","year":"2001","journal-title":"Crit Care Med"},{"key":"R18-20250912","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1183\/09031936.00031607","article-title":"Outcome and prognostic factors of lung cancer patients admitted to the medical intensive care unit","volume":"31","author":"Adam","year":"2008","journal-title":"Eur Respir J"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/hemoncstem.HEMONCSTEM-D-25-00025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:45:17Z","timestamp":1787067917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/hemoncstem.HEMONCSTEM-D-25-00025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,12]]},"references-count":18,"URL":"https:\/\/doi.org\/10.4103\/hemoncstem.hemoncstem-d-25-00025","relation":{},"ISSN":["1658-3876","2589-0646"],"issn-type":[{"value":"1658-3876","type":"print"},{"value":"2589-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,12]]},"assertion":[{"value":"2025-06-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}