{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:46:13Z","timestamp":1792172773959,"version":"4.4.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    T-cell receptor alpha\/beta+ T-cell\/CD19+ B-cell (TCR\u03b1\u03b2+\/CD19+) depletion of allografts is increasingly used as a graft manipulation strategy for allogeneic hematopoietic stem cell transplantation (HSCT) for hematologic malignancies. While outcomes using this approach are encouraging, limited data exist on associated costs and healthcare resource utilization (HRU). We conducted a single-center analysis comparing costs and HRU through HSCT day +100 in patients who received a TCR\u03b1\u03b2+\/CD19+-depleted (TCD) HSCT (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200920) to a contemporary cohort of patients who received a non-TCD HSCT (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u200922). Median total inpatient costs through day +100 were $623,085 (interquartile range (IQR): $356,466\u20131,081,013] for TCD HSCTs and $451,876 (IQR: $313,601\u2013787,351) for non-TCD HSCTs (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.234). Engraftment was rapid, with a median time to neutrophil engraftment of 10.0 versus 21.0 days (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001) and platelet engraftment of 11.0 versus 22.0 days (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001) for TCD and non-TCD HSCTs, respectively. Length of stay for the initial admission was shorter for patients who received a TCD HSCT (28.5 vs. 34.0 days,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.001). Readmission through day +100 was required for 12 (60.0%) TCD patients and 6 (27.3%) non-TCD (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    \u2009=\u20090.060). In summary, while clinical outcomes were comparable, costs and HRU were not decreased after TCR\u03b1\u03b2+\/CD19+ depletion.\n                  <\/jats:p>","DOI":"10.4103\/hemoncstem.hemoncstem-d-26-00042","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:00:15Z","timestamp":1792170015000},"page":"e0042","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparable Inpatient Costs and Resource Utilization with TCR\u03b1\u03b2+\/CD19+-Depleted Compared with Conventional Stem Cell Transplant for Pediatric Hematologic Malignancies"],"prefix":"10.4103","volume":"19","author":[{"given":"Alexander W.","family":"Rankin","sequence":"first","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemalatha G.","family":"Rangarajan","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Stanek","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita","family":"Pai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"College of Pharmacy, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajinder P.","family":"Bajwa","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabanita","family":"Bhunia","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Lamb","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dean A.","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolla F.","family":"Abu-Arja","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplant, Nationwide Children\u2019s Hospital, Columbus, OH, USA"},{"name":"Department of Pediatrics, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6]]},"reference":[{"key":"R1-20261016","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1182\/blood-2014-05-576041","article-title":"Nonpermissive HLA-DPB1 mismatch increases mortality 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A three-year follow-up of procedure efficiency","volume":"22","author":"Li Pira","year":"2016","journal-title":"Biol Blood Marrow Transplant"},{"key":"R37-20261016","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1080\/14653240600932787","article-title":"Determination of residual T- and B-cell content after immunomagnetic depletion: proposal for flow cytometric analysis and results from 103 separations","volume":"8","author":"Schumm","year":"2006","journal-title":"Cytotherapy"},{"key":"R38-20261016","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jcyt.2013.05.014","article-title":"Depletion of T-cell receptor alpha\/beta and CD19 positive cells from apheresis products with the CliniMACS device","volume":"15","author":"Schumm","year":"2013","journal-title":"Cytotherapy"}],"container-title":["Hematology\/Oncology and Stem Cell Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/hemoncstem.hemoncstem-D-26-00042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:00:19Z","timestamp":1792170019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/hemoncstem.hemoncstem-D-26-00042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/hemoncstem.hemoncstem-d-26-00042","relation":{},"ISSN":["1658-3876","2589-0646"],"issn-type":[{"value":"1658-3876","type":"print"},{"value":"2589-0646","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-07-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}