{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:28:23Z","timestamp":1786739303173,"version":"build-2736575974"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mood disorders have been associated with a variety of cardiovascular disease (CVD) risk factors, including inflammation and large arterial stiffness, particularly while depressed, although longitudinal studies have been limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>With measurements at baseline and 8 weeks, the researchers prospectively assessed mood, levels of inflammatory markers (high-sensitivity C-reactive protein and tumor necrosis factor-alpha [TNF-\u03b1]), serum lipids, and large arterial stiffness in a cohort of 26 participants with a diagnosis of a mood disorder, enriched for current depression. Depressive symptoms were measured using the Montgomery\u2013\u0160sberg Depression Rating Scale (MADRS) at baseline and 8 weeks. Associations between depressive symptoms and other measures were assessed using linear mixed models, unadjusted and adjusted for age and body mass index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean age of the participants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 26) was 41.6 (standard deviation [SD] 12.8) years, and 81% were female. During the study, there was a mean (SD) MADRS score improvement of 9.5 (9.4) from baseline to 8 weeks. Reductions in the primary outcome of tumor necrosis factor-\u03b1 with improvement in depression fell short of statistical significance (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.076). In secondary analyses, there was a statistically significant association between improved cholesterol ratio (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.038) and triglycerides (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.042) with improvement in depression. There was no statistically significant change in large arterial stiffness during the study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Improved depressive symptoms were associated with improved cholesterol ratios even after adjustment, suggesting a possible mechanism by which acute mood states may influence CVD risk. Future longitudinal studies with extended and intensive follow-up investigating CVD risk related to acute changes and persistence of mood symptoms are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/hm.hm_24_19","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T01:45:34Z","timestamp":1574646334000},"page":"47-54","source":"Crossref","is-referenced-by-count":7,"title":["Inflammatory and Vascular Correlates of Mood Change Over 8 Weeks"],"prefix":"10.4103","volume":"3","author":[{"given":"Jonathan W.","family":"Birdsall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha L.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluchi J.","family":"Abosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyndsey 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