{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:49:20Z","timestamp":1790912960074,"version":"4.1.0"},"reference-count":81,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T00:00:00Z","timestamp":1761523200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sleep plays a crucial role in regulating immune, endocrine, and skin functions. Increasing evidence suggests that sleep deprivation and circadian rhythm disruption can impact skin pigmentation by influencing melanocyte biology, hormonal balance, and inflammatory pathways. Clinical observations and molecular studies have revealed links between poor sleep and various pigmentary disorders. However, the underlying mechanisms remain incompletely understood, and the causal relationships are still under debate due to physiological confounders such as psychological stress and metabolic dysregulation. This review summarizes recent findings from experimental, clinical, and epidemiological studies on the relationship between sleep quality and skin pigmentation. Relevant literature was retrieved through PubMed and cross-referenced sources, focusing on research involving melanocyte activity, circadian genes (e.g.,\n                    <jats:italic toggle=\"yes\">PER1<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">BMAL1<\/jats:italic>\n                    ), hypothalamo-pituitary axis (HPA) activation, and pigmentation-related dermatological conditions. Both human and animal studies were included. Poor sleep has been shown to alter skin parameters including melanin, hemoglobin, hydration, and trans-epidermal water loss, often through keratinocyte barrier impairment and microbiome imbalance. Disruption of the HPA leads to elevated cortisol and proinflammatory cytokines, further affecting melanogenesis. Clinically, sleep disturbances are associated with pigmentary disorders such as melasma, rosacea, floppy eyelid syndrome, and acanthosis nigricans. Obstructive sleep apnea contributes to pigmentation changes via hypoxia-induced inflammation and vascular remodeling. A newly described disorder, maturational dyschromia, may also involve habitual sleep patterns. Future research integrating wearable technology and artificial intelligence-based skin imaging may enable real-time, individualized assessment of sleep-pigmentation interactions.\n                  <\/jats:p>","DOI":"10.4103\/idoj.idoj_1011_24","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T13:25:29Z","timestamp":1761571529000},"page":"887-893","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Sleep Quality on Skin Color"],"prefix":"10.4103","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2645-7223","authenticated-orcid":false,"given":"Jiali","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3386-297X","authenticated-orcid":false,"given":"Jianjun","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4940-9662","authenticated-orcid":false,"given":"Hong","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,27]]},"reference":[{"key":"R1-20251030","first-page":"165345","article-title":"Psychopharmacology of sleep disorders","author":"Singh","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"R2-20251030","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0140-6736(22)00877-7","article-title":"Circadian rhythms and disorders of the timing of sleep","volume":"400","author":"Meyer","year":"2022","journal-title":"Lancet"},{"key":"R3-20251030","first-page":"42","article-title":"Circadian rhythm and the skin:A review of the literature","volume":"12","author":"Lyons","year":"2019","journal-title":"J Clin Aesthet Dermatol"},{"key":"R4-20251030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000518826","article-title":"Influence of ethnicities and skin color variations in different populations:A 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