{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:56:26Z","timestamp":1790621786551,"version":"4.1.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian Dermatol Online J"],"published-print":{"date-parts":[[2019]]},"DOI":"10.4103\/idoj.idoj_287_18","type":"journal-article","created":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T08:54:17Z","timestamp":1558083257000},"page":"244","source":"Crossref","is-referenced-by-count":37,"title":["Newer treatment modalities in epidermolysis bullosa"],"prefix":"10.4103","volume":"10","author":[{"given":"Leena","family":"Bruckner-Tuderman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/2229-5178.258595-1","first-page":"931","volume-title":"The classification of inherited epidermolysis bullosa (EB): Report of the third international consensus meeting on diagnosis and classification of EB","author":"Fine","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"key-10.4103\/2229-5178.258595-2","first-page":"313","volume-title":"Epidermolysis bullosa: Molecular pathology of connective tissue components in the cutaneous basement membrane zone","author":"Has","year":"2018","journal-title":"Matrix Biol"},{"key":"key-10.4103\/2229-5178.258595-3","first-page":"117","volume-title":"Inherited epidermolysis bullosa and squamous cell carcinoma: A systematic review of 117 cases","author":"Montaudi\u00e9","year":"2016","journal-title":"Orphanet J Rare Dis"},{"key":"key-10.4103\/2229-5178.258595-4","first-page":"658","volume-title":"Recently identified forms of epidermolysis bullosa","author":"McGrath","year":"2015","journal-title":"Ann Dermatol"},{"key":"key-10.4103\/2229-5178.258595-5","first-page":"825","volume-title":"Impact of next generation sequencing on diagnostics in a genetic skin disease clinic","author":"Takeichi","year":"2013","journal-title":"Exp Dermatol"},{"key":"key-10.4103\/2229-5178.258595-6","doi-asserted-by":"crossref","unstructured":"Has C, Fischer J. Inherited epidermolysis bullosa: New diagnostics and new clinical phenotypes. Exp Dermatol 2018. doi: 10.1111\/exd.13668.","DOI":"10.1111\/exd.13668"},{"key":"key-10.4103\/2229-5178.258595-7","first-page":"1508","volume-title":"Integrin a3 mutations with kidney, lung and skin disease","author":"Has","year":"2012","journal-title":"N Engl J Med"},{"key":"key-10.4103\/2229-5178.258595-8","first-page":"1624","volume-title":"Development of a clinical diagnostic matrix for characterizing inherited epidermolysis bullosa","author":"Yenamandra","year":"2017","journal-title":"Br J Dermatol"},{"key":"key-10.4103\/2229-5178.258595-9","first-page":"428","volume-title":"Diagnosis, treatment and management of epidermolysis bullosa","author":"Watkins","year":"2016","journal-title":"Br J Nurs"},{"key":"key-10.4103\/2229-5178.258595-10","first-page":"1010","volume-title":"Progress in epidermolysis bullosa research: Towards treatment and cure","author":"Uitto","year":"2018","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-11","first-page":"330","volume-title":"Therapies for genetic extracellular matrix diseases of the skin","author":"Nystr\u00f6m","year":"2018","journal-title":"Matrix Biol"},{"key":"key-10.4103\/2229-5178.258595-12","first-page":"547","volume-title":"Injury- and inflammation-driven skin fibrosis: The paradigm of epidermolysis bullosa","author":"Nystr\u00f6m","year":"2018","journal-title":"Matrix Biol"},{"key":"key-10.4103\/2229-5178.258595-13","first-page":"1397","volume-title":"Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells","author":"Mavilio","year":"2006","journal-title":"Nat Med"},{"key":"key-10.4103\/2229-5178.258595-14","first-page":"327","volume-title":"Regeneration of the entire human epidermis using transgenic stem cells","author":"Hirsch","year":"2017","journal-title":"Nature"},{"key":"key-10.4103\/2229-5178.258595-15","first-page":"778","volume-title":"Closure of a large chronic wound through transplantation of gene-corrected epidermal stem cells","author":"Bauer","year":"2017","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-16","first-page":"S89 (abstract)","volume-title":"Phase I\/IIa clinical trial for recessive dystrophic epidermolysis bullosa using genetically corrected autologous keratinocytes","author":"Siprashvili","year":"2017","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-17","first-page":"745","volume-title":"High-efficiency RNA-based reprogramming of human primary fibroblasts.Nat Commun","author":"Kogut","year":"2018","journal-title":""},{"key":"key-10.4103\/2229-5178.258595-18","first-page":"5676","volume-title":"Site-specific genome editing for correction of induced pluripotent stem cells derived from dominant dystrophic epidermolysis bullosa","author":"Shinkuma","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2229-5178.258595-19","first-page":"2585","volume-title":"Cut and paste: Efficient homology-directed repair of a dominant negative KRT14 mutation via CRISPR\/Cas9 nickases","author":"Kocher","year":"2017","journal-title":"Mol Ther"},{"key":"key-10.4103\/2229-5178.258595-20","first-page":"68","volume-title":"Deletion of a pathogenic mutation-containing exon of COL7A1 allows clonal gene editing correction of RDEB patient epidermal stem cells","author":"Menc\u00eda","year":"2018","journal-title":"Mol Ther Nucleic Acids"},{"key":"key-10.4103\/2229-5178.258595-21","first-page":"336","volume-title":"Highly branched poly(\u03b2-amino ester)s for skin gene therapy","author":"Zhou","year":"2016","journal-title":"J Control Release"},{"key":"key-10.4103\/2229-5178.258595-22","first-page":"1742","volume-title":"Revertant mosaicism in a human skin fragility disorder results from slipped mispairing and mitotic recombination","author":"Kiritsi","year":"2012","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2229-5178.258595-23","first-page":"98","volume-title":"Successful therapeutic transplantation of revertant skin in epidermolysis bullosa","author":"Gosty\u0144ski","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"key-10.4103\/2229-5178.258595-24","first-page":"1605","volume-title":"Mechanisms of fibroblast cell therapy for dystrophic epidermolysis bullosa: High stability of collagen VII favors long-term skin integrity","author":"Kern","year":"2009","journal-title":"Mol Therapy"},{"key":"key-10.4103\/2229-5178.258595-25","first-page":"2179","volume-title":"Potential of fibroblast cell therapy for recessive dystrophic epidermolysis bullosa","author":"Wong","year":"2008","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-26","first-page":"898","volume-title":"A phase II randomized vehicle-controlled trial of intradermal allogeneic fibroblasts for recessive dystrophic epidermolysis bullosa","author":"Venugopal","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"key-10.4103\/2229-5178.258595-27","first-page":"629","volume-title":"Bone marrow transplantation for recessive dystrophic epidermolysis bullosa","author":"Wagner","year":"2010","journal-title":"N Engl J Med"},{"key":"key-10.4103\/2229-5178.258595-28","first-page":"2150","volume-title":"Genotype, clinical course and therapeutic decision-making in 76 infants with severe generalized junctional epidermolysis bullosa","author":"Hammersen","year":"2016","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-29","first-page":"6","volume-title":"Novel and emerging therapies in the treatment of recessive dystrophic epidermolysis bullosa","author":"Rashidghamat","year":"2017","journal-title":"Intractable Rare Dis Res"},{"key":"key-10.4103\/2229-5178.258595-30","first-page":"2319","volume-title":"Potential of systemic allogeneic mesenchymal stromal cell therapy for children with recessive dystrophic epidermolysis bullosa","author":"Petrof","year":"2015","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-31","first-page":"307","volume-title":"Enzyme replacement therapy for lysosomal diseases: Lessons from 20 years of experience and remaining challenges","author":"Desnick","year":"2012","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"key-10.4103\/2229-5178.258595-32","first-page":"425","volume-title":"Cell- and protein-based therapy approaches for epidermolysis bullosa","author":"Nystr\u00f6m","year":"2013","journal-title":"Methods Mol Biol"},{"key":"key-10.4103\/2229-5178.258595-33","first-page":"26","volume-title":"Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa","author":"Remington","year":"2009","journal-title":"Mol Ther"},{"key":"key-10.4103\/2229-5178.258595-34","first-page":"2387","volume-title":"Targeted exon skipping restores type VII collagen expression and anchoring fibril formation in an in vivo RDEB model","author":"Turczynski","year":"2016","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-35","first-page":"1302","volume-title":"Analysis of the functional consequences of targeted exon deletion in COL7A1 reveals prospects for dystrophic epidermolysis bullosa therapy","author":"Bornert","year":"2016","journal-title":"Mol Ther"},{"key":"key-10.4103\/2229-5178.258595-36","first-page":"1037","volume-title":"A meta-analysis of nonsense mutations causing human genetic disease","author":"Mort","year":"2008","journal-title":"Hum Mutat"},{"key":"key-10.4103\/2229-5178.258595-37","first-page":"1741","volume-title":"Aminoglycosides restore full-length type VII collagen by overcoming premature termination codons: Therapeutic implications for dystrophic epidermolysis bullosa","author":"Cogan","year":"2014","journal-title":"Mol Ther"},{"key":"key-10.4103\/2229-5178.258595-38","first-page":"E6536","volume-title":"Gentamicin induces LAMB3 nonsense mutation readthrough and restores functional laminin 332 in junctional epidermolysis bullosa","author":"Lincoln","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2229-5178.258595-39","first-page":"3028","volume-title":"Gentamicin induces functional type VII collagen in recessive dystrophic epidermolysis bullosa patients","author":"Woodley","year":"2017","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2229-5178.258595-40","first-page":"3479","volume-title":"Gentamicin B1 is a minor gentamicin component with major nonsense mutation suppression activity","author":"Baradaran-Heravi","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2229-5178.258595-41","first-page":"1842","volume-title":"Amlexanox induces enhances premature termination codon read-through in COL7A1 and expression of full length type VII collagen: Potential therapy for recessive dystrophic epidermolysis bullosa","author":"Atanasova","year":"2017","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-42","first-page":"e0173981","volume-title":"Diacerein inhibits the pro-atherogenic & pro-inflammatory effects of IL-1 on human keratinocytes & endothelial cells","author":"Mohan","year":"2017","journal-title":"PLoS One"},{"key":"key-10.4103\/2229-5178.258595-43","first-page":"892","volume-title":"Diacerein orphan drug development for epidermolysis bullosa simplex: A phase 2\/3 randomized, placebo-controlled, double-blind clinical trial","author":"Wally","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"key-10.4103\/2229-5178.258595-44","first-page":"113","volume-title":"Triterpenes promote keratinocyte differentiation in vitro, ex vivo and in vivo: A role for the transient receptor potential canonical (subtype) 6","author":"Woelfle","year":"2010","journal-title":"J Invest Dermatol"},{"key":"key-10.4103\/2229-5178.258595-45","first-page":"5068969","volume-title":"Betulin-based oleogel to improve wound healing in dystrophic epidermolysis bullosa: A prospective controlled proof-of-concept study?","author":"Schwieger-Briel","year":"2017","journal-title":"Dermatol Res Pract"},{"key":"key-10.4103\/2229-5178.258595-46","first-page":"1461","volume-title":"Keratin-dependent TSLP expression suggests a link between skin blistering and atopic disease","author":"Kumar","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"key-10.4103\/2229-5178.258595-47","unstructured":"Castela E, Tulic MK, Rozi\u00e8res A, Bourrat E, Nicolas JF, Kanitakis J, et al. Epidermolysis bullosa simplex generalized severe induces a Th17 response and is improved by apremilast treatment. Br J Dermatol 2018 doi: 10.1111\/bjd. 16897."},{"key":"key-10.4103\/2229-5178.258595-48","first-page":"31","volume-title":"Oral epigallocatechin-3-gallate for treatment of dystrophic epidermolysis bullosa: A multicentre, randomized, crossover, double-blind, placebo-controlled clinical trial","author":"Chiaverini","year":"2016","journal-title":"Orphanet J Rare Dis"},{"key":"key-10.4103\/2229-5178.258595-49","first-page":"1669","volume-title":"A hypomorphic mouse model for dystrophic epidermolysis bullosa reveals disease mechanisms and responds to fibroblast therapy","author":"Fritsch","year":"2008","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2229-5178.258595-50","first-page":"3498","volume-title":"Collagen VII plays a dual role in wound healing","author":"Nystr\u00f6m","year":"2013","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2229-5178.258595-51","first-page":"940","volume-title":"Injury-driven stiffening of the dermis expedites skin carcinoma progression","author":"Mittapalli","year":"2016","journal-title":"Cancer Res"},{"key":"key-10.4103\/2229-5178.258595-52","first-page":"790","volume-title":"Targeting the TGFbeta signalling pathway in disease","author":"Akhurst","year":"2012","journal-title":"Nat Rev Drug Discovery"},{"key":"key-10.4103\/2229-5178.258595-53","first-page":"403","volume-title":"TGF-beta in the pathogenesis and prevention of disease: A matter of aneurysmic proportions","author":"Dietz","year":"2010","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2229-5178.258595-54","first-page":"223","volume-title":"Is losartan the drug for all seasons?","author":"Ramirez","year":"2012","journal-title":"Curr Opin Pharmacol"},{"key":"key-10.4103\/2229-5178.258595-55","first-page":"3907","volume-title":"Monozygotic twins discordant for recessive dystrophic epidermolysis bullosa phenotype highlight the role of TGF-beta signalling in modifying disease severity","author":"Odorisio","year":"2014","journal-title":"Hum Mol Genet"},{"key":"key-10.4103\/2229-5178.258595-56","first-page":"1211","volume-title":"Losartan ameliorates dystrophic epidermolysis bullosa and uncovers new disease mechanisms","author":"Nystrom","year":"2015","journal-title":"EMBO Mol Med"},{"key":"key-10.4103\/2229-5178.258595-57","first-page":"6609","volume-title":"PDGFR alpha-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia","author":"Tamai","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2229-5178.258595-58","first-page":"11008","volume-title":"Systemic high-mobility group box 1 administration suppresses skin inflammation by inducing an accumulation of PDGFR\u03b1(+) mesenchymal cells from bone marrow","author":"Aikawa","year":"2015","journal-title":"Sci Rep"},{"key":"key-10.4103\/2229-5178.258595-59","first-page":"S143 (abstract)","volume-title":"Systemic delivery of HMGB1 promotes tissue regeneration by activating PDGFR\u03b1 cells in a mouse model of epidermolysis bullosa","author":"Shimbo,","year":"2018","journal-title":"J Invest Dermatol"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T18:36:38Z","timestamp":1786732598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.IDOJ_287_18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019]]}},"alternative-id":["258595"],"URL":"https:\/\/doi.org\/10.4103\/idoj.idoj_287_18","relation":{},"ISSN":["2229-5178"],"issn-type":[{"value":"2229-5178","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}