{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:00:28Z","timestamp":1787169628789,"version":"build-2736575974"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Systemic sclerosis (SSc) is an autoimmune connective tissue disorder causing microvascular abnormality leading to Raynaud's phenomenon, skin tightening, and nailfold capillary changes. The patient may have systemic involvement, among them interstitial lung disease (ILD) and pulmonary arterial hypertension are mainly associated with disease-related mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To find out an association between nailfold capillaroscopic changes with ILD severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>An institution based cross-sectional study was performed among the patients of SSc above 18 years. Detailed history was taken. Clinical examinations, nailfold capillaroscopy (NFC) with a dermatoscope and high-resolution computed tomography (HRCT) scan of thorax were done. Data were analyzed in MedCalc statistical software version 20.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Out of total 43 patients, 74.4% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 32) were female. Mean age was 35.05 \u00b1 7.24 years and mean duration 4.28 \u00b1 2.81 years. Diffuse SSc was found in 88.37% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 38). On NFC, early, active, and late patterns were found in 30.2% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 13), 25.6% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 11), and 44.2% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 19) cases, respectively. On HRCT, early, active, and late ILD were present in 18.6% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8), 37.2% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 16), and 30.2% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 13) cases, respectively. ILD changes were absent in 14% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6) though NFC changes were present in them. Respiratory symptoms were absent in 20.93% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 9) patients though all had features of early NFC and among them 9.3% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 4) showed early ILD changes on HRCT. Significant associations were found between NFC changes and ILD severity (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0003), NFC changes and respiratory symptoms (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001) and between ILD changes and respiratory symptoms (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>NFC, an inexpensive procedure, can be performed in all patients of SSc to detect development of early ILD even before appearance of respiratory symptoms to prevent further progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/idoj.idoj_393_21","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T00:02:05Z","timestamp":1646265725000},"page":"216-220","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Nailfold Capillaroscopic Changes as a Marker of Interstitial Lung Disease in Systemic Sclerosis"],"prefix":"10.4103","volume":"13","author":[{"given":"Olympia","family":"Rudra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasmita","family":"Baisya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhadeep","family":"Mallick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gobinda","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240828","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/rheumatology\/kel310","article-title":"Nailfold capillaroscopy is useful for the diagnosis and follow-up of autoimmune rheumatic diseases.A future tool for the analysis of microvascular heart involvement?","volume":"45","author":"Cutolo","year":"2006","journal-title":"Rheumatology (Oxford"},{"key":"R2-6-20240828","first-page":"4","article-title":"The emerging problem of oxidative stress and the role of antioxidants in systemic sclerosis","volume":"19","author":"Herrick","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"R5-6-20240828","doi-asserted-by":"crossref","first-page":"439","DOI":"10.4103\/ijdvl.IJDVL_495_18","article-title":"Nail fold dermoscopy in collagen vascular disorders: A cross-sectional study","volume":"85","author":"Chojer","year":"2019","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R6-6-20240828","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"Classification criteria for systemic sclerosis: An American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"Distler","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"R7-6-20240828","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/art.1780160506","article-title":"Patterns of finger capillary abnormalities in connective tissue disease by 'wide field' microscopy","volume":"16","author":"Maricq","year":"1973","journal-title":"Arthritis Rheum"},{"key":"R8-6-20240828","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/RHU.0000000000000815","article-title":"Nailfold videocapillaroscopy changes are associated with the presence and severity of systemic sclerosis-related interstitial lung disease","volume":"25","author":"Caetano","year":"2019","journal-title":"J Clin Rheumatol"},{"key":"R9-6-20240828","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4103\/idoj.IDOJ_264_19","article-title":"Nailfold capillaroscopy and retinal findings in patients with systemic sclerosis: Is there an association?","volume":"11","author":"Jakhar","year":"2020","journal-title":"Indian Dermatol Online J"},{"key":"R11-6-20240828","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jbspin.2010.02.019","article-title":"Nailfold capillaroscopic findings in systemic sclerosis related lung fibrosis and in idiopathic lung fibrosis","volume":"77","author":"Corrado","year":"2010","journal-title":"Joint Bone Spine"},{"key":"R12-6-20240828","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/art.1780280505","article-title":"Relationship between nailfold capillary abnormalities and organ involvement in systemic sclerosis","volume":"28","author":"Lovy","year":"1985","journal-title":"Arthritis Rheum"},{"key":"R13-6-20240828","first-page":"219","article-title":"Nailfold capillaroscopy abnormalities correlate with cutaneous and visceral involvement in systemic sclerosis patients","volume":"34","author":"Sato","year":"2009","journal-title":"Acta Reumatol Port"},{"key":"R14-6-20240828","doi-asserted-by":"crossref","first-page":"102458","DOI":"10.1016\/j.autrev.2020.102458","article-title":"; EULAR Study Group on Microcirculation in Rheumatic Diseases and the Scleroderma Clinical Trials Consortium Group on Capillaroscopy.Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud's phenomenon and systemic sclerosis","volume":"19","author":"Smith","year":"2020","journal-title":"Autoimmun Rev"},{"key":"R15-6-20240828","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3899\/jrheum.140276","article-title":"Association between nailfold capillaroscopy findings and pulmonary function tests in patients with systemic sclerosis","volume":"42","author":"Castellv\u00ed","year":"2015","journal-title":"J Rheumatol"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.idoj_393_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:11:09Z","timestamp":1787166669000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.idoj_393_21"}},"subtitle":["A Cross-Sectional Study in a Tertiary Care Hospital in Eastern India"],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/idoj.idoj_393_21","relation":{},"ISSN":["2229-5178"],"issn-type":[{"value":"2229-5178","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]}}}