{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:24:38Z","timestamp":1788452678055,"version":"build-2803163510"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Introduction:<\/jats:title>\n Narrow-band (NB) ultraviolet B (UVB) phototherapy has been shown to halt disease progression in vitiligo, but whether there is any difference in the response to NB-UVB seen in patients with progressive vitiligo versus non-progressive vitiligo has not been evaluated.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To evaluate the effect of NB-UVB on progressive versus non-progressive non-segmental vitiligo.<\/jats:p>\n <\/jats:sec>\n \n Study Design:<\/jats:title>\n Prospective observational comparative study.<\/jats:p>\n <\/jats:sec>\n \n Duration:<\/jats:title>\n April 2016-November 2017.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Adult patients having non-segmental vitiligo involving 2-50% body surface area were divided into two subsets; patients developing >5 lesions in the last 1 month or >15 lesions in the last 3 months (progressive vitiligo, Group I) and patients with static disease for the last 6 months (non-progressive vitiligo, Group II). Both groups were treated with NB-UVB for 6 months (26 weeks) cumulatively and its efficacy in halting disease progression, re-pigmentation, side effects and psychosocial impact were evaluated.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Nineteen out of 24 patients with progressive vitiligo had arrest of disease progression. Rest five patients developed lesions at a slower pace. Group II had earlier onset of re-pigmentation, while Group I had more NB-UVB fluence (34.73 J\/cm\n 2<\/jats:sup>\n vs 25.2 J\/cm\n 2<\/jats:sup>\n ,\n P<\/jats:italic>\n value = 0.034), more time for the fluence to be fixed (\n P<\/jats:italic>\n value = 0.001) and more pruritus (\n P<\/jats:italic>\n value = 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n NB-UVB has the potential to halt disease progression in some patients with progressive vitiligo; but is associated with more total NB-UVB fluence and time taken for fixing it. Progressive vitiligo patients have more pruritus as compared to patients with non-progressive vitiligo.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/idoj.idoj_40_21","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T05:38:04Z","timestamp":1627882684000},"page":"701-705","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of NB-UVB in Progressive Versus Non-Progressive Non-Segmental Vitiligo: A Prospective Comparative Study"],"prefix":"10.4103","volume":"12","author":[{"given":"Saurabh","family":"Bhatia","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binod K.","family":"Khaitan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujay","family":"Khandpur","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanika","family":"Sahni","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnubhatla","family":"Sreenivas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, 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