{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:31:11Z","timestamp":1787841071389,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Nail psoriasis is a relatively unexplored clinical feature in the Indian population. Its correlation with cutaneous, musculoskeletal, and serological manifestations was analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>This study included 45 patients with clinically evident nail psoriasis. Clinical characteristics, Psoriasis Area and Severity Index (PASI), Nail Psoriasis Severity Index (NAPSI), Nail Psoriasis Quality of Life Index 10 (NPQ10) scores and serological markers, Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), and Rheumatoid Arthritis factor (RA factor) were documented, calculated, and assessed to study their correlation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean age was 35.36 \u00b1 13.26 years. Mean NAPSI and NPQ10 were 41.96 \u00b1 29.38 and 5.44 \u00b1 5.31, respectively. Common nail findings were onycholysis (80%), subungual hyperkeratosis (75.5%), and pitting (62.2%). Joint involvement was seen in 31.11% of patients. Positive associations of NAPSI with duration of illness (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001, \u03b2 = 0.57) and PASI scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001, \u03b2 = 0.56) were observed. NPQ10 demonstrated associations with NAPSI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001, \u03b2 = 0.83) and PASI (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001, \u03b2 = 0.83). Elevated ESR and CRP levels were associated with higher NAPSI scores (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001, \u03b2 = 0.55, and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.003, \u03b2 = 0.43, respectively). Furthermore, duration of illness, NAPSI, and NPQ10 scores were positively correlated with joint involvement (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A strong correlation between nail psoriasis severity, disease duration, skin involvement, and nail-specific quality of life was observed. Furthermore, severe nail psoriasis was linked to a higher likelihood of joint involvement and elevated serological markers. These findings emphasize the importance of integrated treatment strategies for affected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/idoj.idoj_474_24","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T05:03:28Z","timestamp":1733979808000},"page":"123-128","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Study on the Clinico-serological Features of Nail Psoriasis"],"prefix":"10.4103","volume":"16","author":[{"family":"Ratnika","sequence":"first","affiliation":[{"name":"Department of Dermatology, Era\u2019s Lucknow Medical College, Era\u2019s University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Adil","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Suhail","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,11]]},"reference":[{"key":"R1-20241226","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jaad.2012.08.015","article-title":"Psoriasis and metabolic syndrome: A systematic review and meta-analysis of observational studies","volume":"68","author":"Armstrong","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"R2-20241226","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4103\/0378-6323.72443","article-title":"Psoriasis in India: Prevalence and pattern","volume":"76","author":"Dogra","year":"2010","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R3-20241226","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaad.2005.07.073","article-title":"Psoriasis of the nail: Anatomy, pathology, clinical presentation, and a review of the literature on therapy","volume":"57","author":"Jiaravuthisan","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"R4-20241226","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000377709","article-title":"Nail Psoriasis in children: Common or uncommon? 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