{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:13:18Z","timestamp":1791925998657,"version":"4.3.4"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acanthosis nigricans (AN) presents a significant challenge for dermatologists, as it is a common condition yet often proves resistant to treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim and Objective:<\/jats:title>\n                    <jats:p>To compare the effects of 0.025% topical tretinoin, 4% retinol peel, and 10% retinol peel, in the management of AN of neck using Acanthosis Nigricans Area Severity Index (ANASI) score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>Patients with AN of neck were recruited to the study with due consideration to the inclusion criteria and were divided into 3 groups based on the treatment administered which was either 0.025% topical tretinoin, 4% retinol peel, or 10% retinol peel. The patients were followed-up every 2 weeks up to 8 weeks with ANASI score and Likert scale.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All the groups demonstrated statistically significant improvement but participants in the topical group achieved a slightly better reduction, with a mean ANASI score of 10 at final follow-up, followed by 10% retinol and 4% retinol peel with a mean ANASI score of 12 and 11, respectively. Overall, though 4% retinol peel group had the least reported side effects, patient satisfaction score was found to be higher among the participants in the topical group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>Small sample size and allocation of patients to different treatment groups was not randomized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Among the three groups, topical tretinoin group showed better response when compared to 4% and 10% retinol peels and, as such, can be a preferred mode of treatment since it is also cost effective over the more expensive chemical peels. Thus, in the era of chemical peels and lasers, topical treatment with retinoids still holds good.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/idoj.idoj_506_24","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T05:00:09Z","timestamp":1744952409000},"page":"414-419","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A Study Comparing 0.025% Topical Tretinoin Versus 4% Retinol Peel and 10% Retinol Peel in the Management of Acanthosis Nigricans"],"prefix":"10.4103","volume":"16","author":[{"given":"Shreya","family":"Srinivasan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8756-9125","authenticated-orcid":false,"given":"C","family":"Balakumaran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Sukanya","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Sakthi","family":"Megalai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aswin","family":"Senthilvel","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Sree Balaji Medical College and Hospital, Chromepet, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,17]]},"reference":[{"key":"R1-20250503","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1370\/afm.678","article-title":"Acanthosis nigricans and diabetes risk factors:Prevalence in young persons seen in south-western US primary care practices","volume":"5","author":"Kong","year":"2007","journal-title":"Ann Fam Med"},{"key":"R2-20250503","doi-asserted-by":"crossref","first-page":"678","DOI":"10.4103\/0019-5154.91828","article-title":"A study of pathogenesis of acanthosis nigricans and its clinical implications","volume":"56","author":"Puri","year":"2011","journal-title":"Indian J Dermatol"},{"key":"R3-20250503","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/pigmentinternational.pigmentinternational_25_23","article-title":"Facial acanthosis nigricans\u2013A narrative review","volume":"10","author":"Sarkar","year":"2023","journal-title":"Pigment Int"},{"key":"R4-20250503","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1007\/s12325-022-02319-7","article-title":"Use of retinoids in topical antiaging treatments:A focused review of clinical evidence for conventional and nanoformulations","volume":"39","author":"Milosheska","year":"2022","journal-title":"Adv Ther"},{"key":"R5-20250503","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/jewd.jewd_65_20","article-title":"Use of a novel quantitative tool for evaluation of pseudo-acanthosis nigricans:Acanthosis nigricans area and severity index (ANASI)","volume":"18","author":"Zaki","year":"2021","journal-title":"J Egypt Womens Dermatol Soc"},{"key":"R6-20250503","first-page":"55","article-title":"A technique for the measurement of attitudes","volume":"22","author":"Likert","year":"1932","journal-title":"Arch Psychology"},{"key":"R7-20250503","first-page":"20","article-title":"Post inflammatory hyperpigmentation:A review of the epidemiology, clinical features, and treatment options in skin of color","volume":"3","author":"Davis","year":"2010","journal-title":"J Clin Aesthet Dermatol"},{"key":"R8-20250503","first-page":"40","article-title":"Tolerability and efficacy of retinoic acid given after full-face peel treatment of photodamaged skin","volume":"4","author":"Gold","year":"2011","journal-title":"J Clin Aesthet Dermatol"},{"key":"R9-20250503","first-page":"170","article-title":"To compare the efficacy and safety of trichloroacetic acid peel with topical tretinoin in the treatment of acanthosis nigricans:A randomized controlled study","volume":"29","author":"Rajegowda","year":"2019","journal-title":"J Pakistan Assoc Dermatologists"},{"key":"R10-20250503","first-page":"273","article-title":"Acanthosis nigricans:An extensive review","volume":"31","author":"Salati","year":"2021","journal-title":"J Pak Assoc Dermatol"},{"key":"R11-20250503","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.clindermatol.2015.04.010","article-title":"Acanthosis nigricans:A fold (intertriginous) dermatosis","volume":"33","author":"Kutlubay","year":"2015","journal-title":"Clin Dermatol"},{"key":"R12-20250503","first-page":"1658","article-title":"FGF21 is associated with acanthosis nigricans in obese patients","volume":"2","author":"Huang","year":"2016","journal-title":"Int J Endocrinol"},{"key":"R13-20250503","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/CCID.S137527","article-title":"Current treatment options for acanthosis nigricans","volume":"11","author":"Patel","year":"2018","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"R14-20250503","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2337\/diacare.26.5.1333","article-title":"The significance of impaired fasting glucose versus impaired glucose tolerance:Importance of insulin secretion and resistance","volume":"26","author":"Carnevale","year":"2003","journal-title":"Diabetes Care"},{"key":"R15-20250503","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/16089677.2014.11073603","article-title":"Acanthosis nigricans:A flag for insulin resistance","volume":"19","author":"Venkatswami","year":"2014","journal-title":"J Endocrinol Metabol Diabetes South Afr"},{"key":"R16-20250503","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/jocd.13544","article-title":"Acanthosis nigricans:A review","volume":"19","author":"Das","year":"2020","journal-title":"J Cosmet Dermatol"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.idoj_506_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:42:49Z","timestamp":1787773369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.idoj_506_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,17]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/idoj.idoj_506_24","relation":{},"ISSN":["2229-5178","2249-5673"],"issn-type":[{"value":"2229-5178","type":"print"},{"value":"2249-5673","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,17]]},"assertion":[{"value":"2024-05-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}