{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:25:27Z","timestamp":1787793927223,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Chronic acral hyperkeratotic dermatosis includes several conditions such as lichen simplex chronicus (LSC), hypertrophic lichen planus (HLP), psoriasis vulgaris (Ps), acral acanthosis nigricans, acquired zinc deficiency, and necrolytic acral erythema (NAE). LSC, Ps, and HLP respond to conventional treatments such as topical corticosteroids, immuno-modulators such as tacrolimus, and oral methotrexate. Zinc-responsive acral hyperkeratosis is a novel entity that resembles the above mentioned diagnoses clinically but fails to respond to the above treatment options. NAE is a rare condition, commonly associated with hepatitis C virus infection and manifest similar clinical features of zinc-responsive acral hyperkeratosis, but differs histopathologically. Both conditions show a good response to oral zinc supplementation. As there is a paucity of literature on zinc-responsive acral hyperkeratosis, we are highlighting the case.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/idoj.idoj_557_20","type":"journal-article","created":{"date-parts":[[2021,11,21]],"date-time":"2021-11-21T11:01:13Z","timestamp":1637492473000},"page":"892-895","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Zinc-Responsive Acral Hyperkeratosis"],"prefix":"10.4103","volume":"12","author":[{"given":"Priyanka A.","family":"Kowe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Bhushan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaishali H.","family":"Wankhade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20240828","doi-asserted-by":"crossref","first-page":"136","DOI":"10.4103\/0019-5154.152507","article-title":"Zinc-responsive acral hyperkeratotic dermatosis-A novel entity or a subset of some well-known dermatosis","volume":"60","author":"Ghosh","year":"2015","journal-title":"Indian J Dermatol"},{"key":"R2-16-20240828","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-4362.1996.tb02997.x","article-title":"Necrolyticacral erythema: A cutaneous marker of viral hepatitis C","volume":"35","author":"El Darouti","year":"1996","journal-title":"Int J Dermatol"},{"key":"R3-16-20240828","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/j.1365-4632.2004.02232.x","article-title":"Necrolytic acral erythema: A variant of necrolytic migratory erythema or a distinct entity","volume":"44","author":"Nofal","year":"2005","journal-title":"Int J Dermatol"},{"key":"R4-16-20240828","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jaad.2005.04.049","article-title":"Necrolytic acral erythema: A cutaneous sign of hepatitis C virus infection","volume":"53","author":"Abdallah","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"R5-16-20240828","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/j.1365-4632.2009.04114.x","article-title":"Necrolyticacral erythema seronegative for hepatitis C virus-two cases from India treated with oral zinc","volume":"48","author":"Nikam","year":"2009","journal-title":"Int J Dermatol"},{"key":"R6-16-20240828","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1600-0560.2008.01037.x","article-title":"Necrolytic acral erythema without hepatitis C infection","volume":"36","author":"Wu","year":"2009","journal-title":"J Cutan Pathol"},{"key":"R7-16-20240828","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4103\/0019-5154.70676","article-title":"Seronegative necrolytic acral erythema: A distinct clinical subset","volume":"55","author":"Panda","year":"2010","journal-title":"Indian J Dermatol"},{"key":"R8-16-20240828","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/2229-5178.185464","article-title":"Seronegative necrolytic acral erythema: A report of two cases and literature review","volume":"7","author":"Pandit","year":"2016","journal-title":"Indian Dermatol Online J"},{"key":"R9-16-20240828","first-page":"354","article-title":"Histological study of necrolytic acral erythema","volume":"100","author":"Abdallah","year":"2004","journal-title":"J Ark Med Soc"},{"key":"R10-16-20240828","doi-asserted-by":"crossref","first-page":"492","DOI":"10.4103\/0019-5154.103073","article-title":"Acquired zinc deficiency in an adult female","volume":"57","author":"Saritha","year":"2012","journal-title":"Indian J Dermatol"},{"key":"R11-16-20240828","doi-asserted-by":"crossref","first-page":"709152","DOI":"10.1155\/2014\/709152","article-title":"Zinc therapy in dermatology: A review","volume":"2014","author":"Gupta","year":"2014","journal-title":"Dermatol Res Pract"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.IDOJ_557_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:14:26Z","timestamp":1787166866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.IDOJ_557_20"}},"subtitle":["A Report of a Rare Entity"],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/idoj.idoj_557_20","relation":{},"ISSN":["2229-5178"],"issn-type":[{"value":"2229-5178","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]}}}