{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:55Z","timestamp":1786650115774,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      The calcium ion (Ca\n                      <jats:sup>2+<\/jats:sup>\n                      ) signaling is a fundamental cellular process vital for proliferation and differentiation. Its dysregulation is a recognized driver of carcinogenesis, contributing to uncontrolled cellular growth, survival, and metastasis. The inositol 1,4,5-triphosphate receptor (IP3R), a pivotal Ca\n                      <jats:sup>2+<\/jats:sup>\n                      channel located primarily on the endoplasmic reticulum, is critical for mediating intracellular Ca\n                      <jats:sup>2+<\/jats:sup>\n                      release and is implicated in cancer development.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim and Objectives:<\/jats:title>\n                    <jats:p>To evaluate the immunolocalization of IP3R-1 in normal skin, squamous cell dysplasia, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC), and to determine its association with clinicopathological features such as genesis, infiltration, differentiation, and aggressiveness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>This investigation employed a descriptive and analytical study design to examine IP3R-1 expression within human tissue samples. The methodology involved collecting and analyzing archival specimens from patients diagnosed with non-melanoma skin cancers and pre-malignant lesions, as well as normal skin samples for comparative assessment. The role of IP3R-1 in skin cancer was assessed by immunohistochemistry. Expression patterns were analyzed using an IP3R-1 antibody and correlated with clinicopathological data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Immunohistochemical analysis revealed distinct patterns of IP3R-1 expression. IP3R-1 was consistently expressed within the basal layer of normal epidermis, but was absent in suprabasal cells. A marked increase in IP3R-1 expression was observed in atypical cells within dysplastic lesions. Furthermore, significant overexpression of IP3R-1 was evident in SCC and BCC, irrespective of histological subtype or differentiation. However, no correlation was found between IP3R-1 expression and clinicopathological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>The findings lack confirmation through direct molecular assays and are based solely on immunohistochemical expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>These findings strongly suggest that IP3R-1 plays a significant role in the development and progression of skin cancer, with its altered expression observed early in carcinogenesis. Nevertheless, its expression does not correlate with typical clinical-pathological aspects of neoplasia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/idoj.idoj_694_25","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:00:06Z","timestamp":1776229206000},"page":"380-385","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of Immunolocalization of IP3R-1 in Skin Epithelium and its Changes in Non-Melanoma Skin Cancer: An Immuno-Histochemical and Clinical-Pathological Study"],"prefix":"10.4103","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-2534","authenticated-orcid":false,"given":"Cristiane R.","family":"Gruber","sequence":"first","affiliation":[{"name":"Mackenzie Evangelical School of Medicine Paran\u00e1, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7699-3542","authenticated-orcid":false,"given":"Thelma L.","family":"Skare","sequence":"additional","affiliation":[{"name":"Mackenzie Evangelical School of Medicine Paran\u00e1, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9899-5493","authenticated-orcid":false,"given":"Marcos F.","family":"Sigwalt","sequence":"additional","affiliation":[{"name":"Mackenzie Evangelical School of Medicine Paran\u00e1, Curitiba, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4235-1410","authenticated-orcid":false,"given":"Graziela J. 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