{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:20:57Z","timestamp":1787764857756,"version":"build-2784847793"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:p>Vulvar squamous cell carcinoma with sarcomatoid features is an extremely rare histological variant of squamous cell carcinoma with co-existence of both epithelial and mesenchymal features. A 70-year-old woman presented with genital lesions for 4 months with associated burning and pain. Examination revealed well-defined bilaterally symmetrical hyperpigmented plaques on labia majora, fleshy erythematous growth on labia minora. Biopsy from the fleshy mass was suggestive of sarcomatoid malignancy. However, immunohistochemistry was positive for cytokeratin AE1\/AE3 and negative for desmin and smooth muscle actin. Biopsy from hyperpigmented plaque was suggestive of Bowens disease. On the basis of histopathology and immunohistochemistry findings, diagnosis of vulvar sarcomatoid squamous cell carcinoma with Bowens disease was made and patient was started on external beam radiation therapy. Sarcomatoid squamous cell carcinoma of vulva is very rare cancer that has an aggressive and fatal course. Diagnosis has traditionally been difficult due to a large ratio of sarcomatous to squamous cell component. Due to its rarity, there are no distinct guidelines to direct therapy and care.<\/jats:p>","DOI":"10.4103\/idoj.idoj_696_22","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T15:03:39Z","timestamp":1698419019000},"page":"856-860","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Vulvar Sarcomatoid Squamous Cell Carcinoma: A Rare Entity"],"prefix":"10.4103","volume":"14","author":[{"given":"Gayatri","family":"Gund","sequence":"first","affiliation":[{"name":"Department of Dermatology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akansha","family":"Chadha","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Dongre","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chitra","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"R2-20260511","first-page":"363","article-title":"Squamous cell carcinoma with sarcomatoid features of the vulva: A case report and review of literature","volume":"103","author":"Choi","year":"2006","journal-title":"GynecolOncol"},{"key":"R3-20260511","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/1097-0142(19830901)52:5<890::AID-CNCR2820520525>3.0.CO;2-T","article-title":"Squamous cell carcinoma with sarcoma-like stroma of the female genital tract. 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