{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:23:19Z","timestamp":1787844199473,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>India has a high prevalence of tuberculosis and latent tuberculosis infection (LTBI) is common in the general population. LTBI can progress to active tuberculosis in almost 10% patients and the risk increases with immunosuppression. This predisposes patients of psoriasis on systemic therapy for the development of active tuberculosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To find the prevalence of LTBI in patients with psoriasis planned for systemic therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>It was a prospective observational study conducted in a tertiary care center during period Jan-Dec 2019. Patients older than 18 years with chronic plaque psoriasis planned for systemic therapy and willing to be part of the study were included. Baseline clinical data were collected. Radiograph of chest and tuberculin skin test (TST) was performed in all patients. Detailed evaluation including sputum examination and computed tomography of the chest and abdomen were performed in patients with TST &gt;10 mm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 105 patients met the inclusion criteria of the study, with the mean age of patients being 29.5 \u00b1 2.12 years. Out of these patients, 58 were males and 47 females. The mean duration of psoriasis was 2.95 \u00b1 1.3 years. The mean PASI score was 16.71 \u00b1 4.384. Mantoux was positive (&gt;10 mm) in 33 (31.42%) patients. Two patients were found to have features of active tuberculosis based on imaging and microbiological investigations. Totally, 31 (29.5%) patients had LTBI and were treated with isoniazid and rifampicin for three months while 2 (1.9%) patients were treated with four drugs antitubercular regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>Small sample size, convenience method of sampling and study population limited to those visiting medical college hospital are its major limitations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>LTBI is common in study population and screening for LTBI should be performed in all patients of psoriasis planned for systemic therapy. A thorough search for active tuberculosis should be performed. Timely detection of LTBI helps in the prevention of development of active tuberculosis in the patients on immunosuppressive treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/idoj.idoj_698_20","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T05:39:29Z","timestamp":1620797969000},"page":"429-432","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Latent Tuberculosis in Psoriasis Patients Planned for Systemic Therapy \u2013 A Prospective Observational Study"],"prefix":"10.4103","volume":"12","author":[{"given":"Shekhar","family":"Neema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Radhakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Disha","family":"Dabbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biju","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20240828","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-2004-829504","article-title":"Latent tuberculosis infection","volume":"25","author":"Nuermberger","year":"2004","journal-title":"Semin Respir Crit Care Med"},{"key":"R2-8-20240828","doi-asserted-by":"crossref","first-page":"e89524","DOI":"10.1371\/journal.pone.0089524","article-title":"Latent TB infection diagnosis in population exposed to TB subjects in close and poor ventilated high TB endemic zone in India","volume":"9","author":"Kashyap","year":"2014","journal-title":"PLoS One"},{"key":"R3-8-20240828","doi-asserted-by":"crossref","first-page":"e0219131","DOI":"10.1371\/journal.pone.0219131","article-title":"High risk for latent tuberculosis infection among medical residents and nursing students in India","volume":"14","author":"Kinikar","year":"2019","journal-title":"PLoS One"},{"key":"R4-8-20240828","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tube.2015.04.003","article-title":"Latent tuberculosis infection--Revisiting and revising concepts","volume":"95","author":"Salgame","year":"2015","journal-title":"Tuberculosis (Edinb"},{"key":"R5-8-20240828","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12879-017-2301-4","article-title":"Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: Systematic review and meta-analysis","volume":"17","author":"Auguste","year":"2017","journal-title":"BMC Infect Dis"},{"key":"R8-8-20240828","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jaad.2008.03.023","article-title":"National Psoriasis Foundation consensus statement on screening for latent tuberculosis infection in patients with psoriasis treated with systemic and biologic agents","volume":"59","author":"Doherty","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"R9-8-20240828","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1111\/jdv.12011","article-title":"Latent tuberculosis infection and active tuberculosis in patients with psoriasis: A study on the incidence of tuberculosis and the prevalence of latent tuberculosis disease in patients with moderate\u2013severe psoriasis in Spain. BIOBADADERM registry","volume":"27","author":"S\u00e1nchez-Moya","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R10-8-20240828","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/cid\/ciw778","article-title":"Official American Thoracic Society\/Infectious Diseases Society of America\/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of tuberculosis in adults and children","volume":"64","author":"Lewinsohn","year":"2017","journal-title":"Clin Infect Dis"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.IDOJ_698_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:14:06Z","timestamp":1787843646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.IDOJ_698_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/idoj.idoj_698_20","relation":{},"ISSN":["2229-5178"],"issn-type":[{"value":"2229-5178","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}