{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:25:52Z","timestamp":1788791152451,"version":"build-2803163510"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There have been sporadic and periodic large-scale epidemics of hand, foot, and mouth disease (HFMD) with cases at risk for significant morbidity and mortality particularly in Southeast Asia since 1997 and in India since early 2003.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>We retrospectively studied 403 cases recorded from 2009 to 2019 and reviewed relevant Indian literature published between 2004 and 2019 to understand clinical, epidemiological, and virological attributes of this long-lasting Indian epidemic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>There were 96.8% children and adolescents (M:F 1.6:1) aged 2 months to 18 years and 84% were aged &lt;5 years. Adult family contacts comprised 3.2%. Only 12 sporadic cases occurred during 2009-2011 followed by increased number from 2012 to 2015 peaking with 30.8% cases in 2013 and declining slowly until the year 2019 with small resurge in 2018. The major peaks occurred during summers with small peaks in autumns. Literature review showed 3332 cases presenting between 2004 and 2019 across Indian states with similar epidemiological trends whereas serotyping identified Coxsackievirus A16 (CV A16) in 83%, Coxsackievirus A6 (CV A6) in 17%, Enterovirus 71 in 4.1%, and multiple strains in 11.7% samples, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The overall features of this long-lasting HFMD epidemic; affecting children aged &lt;5 years more often than adults, none or minimum neurological or pulmonary complications in few patients, peaks occurring during summer and autumn months, and identity of the pathogenic virus coincide with global trends. However, the continuous spread of the disease across the country appears in sync with pre-epidemic periods of China and Taiwan. It calls for a continuous surveillance and making HFMD a notifiable disease in India.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/idoj.idoj_701_21","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T07:16:01Z","timestamp":1653462961000},"page":"310-320","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":20,"title":["Hand, Foot and Mouth Disease"],"prefix":"10.4103","volume":"13","author":[{"given":"Anuj","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram K.","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karaninder S.","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pushpinder S.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujaya","family":"Manvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20240828","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1017\/S0950268817000309","article-title":"Epidemics and aetiology of hand, foot and mouth disease in Xiamen, China, from 2008 to 2015","volume":"145","author":"He","year":"2017","journal-title":"Epidemiol Infect"},{"key":"R2-2-20240828","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1002\/jmv.24798","article-title":"Characterization of genome sequences and clinical features of coxsackievirus A6 strains collected in Hyogo, Japan in 1999\u20132013","volume":"89","author":"Ogi","year":"2017","journal-title":"J Med Virol"},{"key":"R3-2-20240828","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000354533","article-title":"Coxsackievirus A6 and hand, foot and mouth disease:Three case reports of familial child-to-immunocompetent adult transmission and a literature review","volume":"5","author":"Kaminska","year":"2013","journal-title":"Case Rep Dermatol"},{"key":"R4-2-20240828","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/1743-422X-7-300","article-title":"Retrospective seroepidemiology indicated that human enterovirus 71 and coxsackievirus A16 circulated wildly in central and southern China before large scale outbreaks from 2008","volume":"7","author":"Zhu","year":"2010","journal-title":"Virol J"},{"key":"R5-2-20240828","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s12879-015-1233-0","article-title":"Time series analysis of reported cases of hand, foot, and mouth disease from 2010 to 2013 in Wuhan, China","volume":"15","author":"Chen","year":"2015","journal-title":"BMC Infect Dis"},{"key":"R7-2-20240828","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s12250-011-3195-8","article-title":"Hand foot and mouth disease due to enterovirus 71 in Malaysia","volume":"26","author":"Chua","year":"2011","journal-title":"Virol Sin"},{"key":"R8-2-20240828","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. 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