{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:19:46Z","timestamp":1787750386737,"version":"build-2784847793"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Vitiligo is an autoimmune disorder characterized by the destruction of epidermal melanocytes, leading to white lesions devoid of pigmentation. The destruction of epidermal melanocytes is driven by tissue-resident and circulating immune cells that maintain an inflammatory milieu. Two percent of the global population suffers from vitiligo, with a higher prevalence reported in the Indian population. Narrow-band UV-B (NBUVB) phototherapy is commonly used as an economical, non-invasive, and well-tolerated treatment modality. NBUVB promotes the migration of melanocyte stem cells (MelSC) to the epidermis, thus restoring pigmentation in affected individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims and Objectives:<\/jats:title>\n                    <jats:p>This study aimed to investigate the histological and gene expression changes in Indian vitiligo patients pre- and post-NBUVB phototherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods:<\/jats:title>\n                    <jats:p>Indian patients with stable vitiligo underwent NBUVB monotherapy, administered thrice weekly for three months, to induce repigmentation. Single 3 mm skin biopsies were taken from vitiligo lesions pre- and post-NBUVB phototherapy for histopathological and gene expression analysis. A contralateral pigmented region was considered as the control skin from the same patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Following NBUVB monotherapy, melanocytes were restored in the epidermis of vitiligo patients and produced melanin pigment. The mean area of pigmentation post-NBUVB therapy was 2.94% \u00b1 0.97%, compared to 0.11% \u00b1 0.19% in vitiligo lesions before NBUVB therapy. Following NBUVB phototherapy, melanocytes migrating from the hair bulge upregulated key genes in melanocyte differentiation (PAX3) and melanogenesis (KIT, TYR, DCT\/TRP2). In addition to the favorable clinical outcome of repigmentation, NBUVB was effective in reducing the skin T-cells, indicating successful immunosuppression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Limitations:<\/jats:title>\n                    <jats:p>The major limitation of our study was the limited sample size of our patient cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study reaffirms the therapeutic efficacy of NBUVB in promoting repigmentation in an Indian cohort of vitiligo patients. Furthermore, NBUVB is effective in reducing CD3+ skin-resident T-cells, widely considered a major contributor to the pathogenesis of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/idoj.idoj_703_25","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:00:10Z","timestamp":1782320410000},"page":"504-511","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Melanocytes and T-cells in Vitiliginous Skin Pre- and Post-Narrow-Band UVB Phototherapy"],"prefix":"10.4103","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-7032-1921","authenticated-orcid":false,"given":"Abhik","family":"Dutta","sequence":"first","affiliation":[{"name":"IFOM-InStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bengaluru, Karnataka, India"},{"name":"School of Chemical and Biotechnology (SCBT), Shanmugha Arts, Science, Technology and Research Academy (SASTRA), Thanjavur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-4853","authenticated-orcid":false,"given":"Dyuti","family":"Saha","sequence":"additional","affiliation":[{"name":"IFOM-InStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5677-1637","authenticated-orcid":false,"given":"T S","family":"Nagesh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sapthagiri Institute of Medical Sciences and Research Center, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9581-3907","authenticated-orcid":false,"given":"Shanaya Surendra Phal","family":"Desai","sequence":"additional","affiliation":[{"name":"IFOM-InStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Poojary","sequence":"additional","affiliation":[{"name":"IFOM-InStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-2972","authenticated-orcid":false,"given":"Colin","family":"Jamora","sequence":"additional","affiliation":[{"name":"IFOM-InStem Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis, Institute for Stem Cell Biology and Regenerative Medicine, Bengaluru, Karnataka, 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