{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:20:21Z","timestamp":1787840421330,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Thymic stromal lymphopoietin (TSLP) is a cytokine initially implicated to be associated with allergic disorders inducing Th2 response. Emerging studies have shown that TSLP is also involved in autoimmune diseases. In psoriasis, TSLP acts in synergy with T cell-derived CD40L to promote the release of IL-23 from dendritic cells. IL-23 is responsible for the inappropriate immune reaction and keratinocyte proliferation in psoriasis. Targeting TSLP could be a novel therapeutic approach in the treatment of psoriasis.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To compare the serum levels of TSLP between patients with psoriasis and healthy individuals.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A prospective hospital-based case-control study was carried out on 38 patients with psoriasis. The severity of psoriasis was graded into mild, moderate, and severe according to PASI. A total of 30 healthy individuals with matched age and sex were taken as controls. 5 ml of venous blood was collected, centrifuged, and the collected serum was stored at -80\u00b0C until quantitative assessment by sandwich enzyme-linked immunosorbent assay (ELISA) technique.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n TSLP has been found to be significantly elevated in the sera of cases (0.1380178 pg\/ml) than in controls (0.1125974 pg\/ml). There was also a significant proportionate increase in the mean TSLP with the mean PASI score.<\/jats:p>\n <\/jats:sec>\n \n Limitations:<\/jats:title>\n The sample size was small and we could not follow-up the cases to study the changes in TSLP levels with remission of the lesions.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n We found that serum TSLP was elevated in psoriasis patients and correlated with disease severity, indicating a possible pathogenetic role.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/idoj.idoj_742_23","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T12:20:26Z","timestamp":1714393226000},"page":"449-453","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A Comparative Study on Serum Levels of \u201cThymic Stromal Lymphopoietin\u201d Between Patients with Psoriasis Vulgaris and Healthy Individuals: A Case-Control Study"],"prefix":"10.4103","volume":"15","author":[{"given":"Siri Sri","family":"Kollabathula","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konakanchi","family":"Venkatachalam","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Government Medical College, Srikakulam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kethireddi","family":"Susmitha Divya","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patnala","family":"Guruprasad","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Andhra Medical College, Visakhapatnam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallapati Anila Sunandini","family":"Nayar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy, Government Medical College, Srikakulam, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"R1-20250921","first-page":"11","article-title":"Psoriasis--new insights into pathogenesis and treatment","volume":"106","author":"Mrowietz","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"R2-20250921","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nm0595-442","article-title":"Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis","volume":"1","author":"Gottlieb","year":"1995","journal-title":"Nat 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potently activates CD1c+myeloid dendritic cells to attract and stimulate T cells","volume":"66","author":"Moret","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"R7-20250921","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jaci.2014.04.022","article-title":"Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis","volume":"134","author":"Volpe","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"R8-20250921","first-page":"59","article-title":"Serum TSLP is a potential biomarker of psoriasis vulgaris activity","volume":"9","author":"El-Ghareeb","year":"2019","journal-title":"Psoriasis (Auckl)"},{"key":"R9-20250921","doi-asserted-by":"crossref","first-page":"8006","DOI":"10.4081\/dr.2019.8006","article-title":"Skin tissue expression and serum level of thymic stromal lymphopoietin in patients with psoriasis vulgaris","volume":"11","author":"Suwarsa","year":"2019","journal-title":"Dermatol Rep"},{"key":"R10-20250921","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJMoa1704064","article-title":"Tezepelumab in adults with uncontrolled asthma","volume":"377","author":"Corren","year":"2017","journal-title":"N Engl J Med"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.idoj_742_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:20Z","timestamp":1787836940000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.idoj_742_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/idoj.idoj_742_23","relation":{},"ISSN":["2229-5178","2249-5673"],"issn-type":[{"value":"2229-5178","type":"print"},{"value":"2249-5673","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]},"assertion":[{"value":"2023-09-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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