{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T19:18:21Z","timestamp":1788376701452,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Cutaneous warts are benign epidermal growths caused by low-risk human papillomavirus. Interferon promotes an \u201cantiviral state\u201d in infected cells and neighboring cells through the activation of interferon-stimulated genes. The suppressor of cytokine signaling (SOCS) proteins bind to both Janus kinase and tyrosine kinase receptors, which further inhibit signal transducer and activator of transcription 3 phosphorylation.<\/jats:p>\n <\/jats:sec>\n \n Aim and Objectives:<\/jats:title>\n \n This study aimed to assess the tissue gene expression of\n SOCS3<\/jats:italic>\n and interferons alpha and beta (\n IFN-\u03b1<\/jats:italic>\n and\n \u03b2<\/jats:italic>\n ) in common warts.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods:<\/jats:title>\n \n Forty patients with common warts, aged between 18 and 50 years, and 40 healthy controls were recruited. The gene expression of\n IFN-\u03b1, IFN-\u03b2,<\/jats:italic>\n and\n SOCS3<\/jats:italic>\n by real-time reverse transcription polymerase chain reaction in the skin biopsies from the warts, normal skin of the patients, and healthy controls was estimated.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The median level of\n IFN-\u03b1<\/jats:italic>\n was significantly higher in warts than non-lesional skin (20.8 vs 1) and both were significantly higher than that of control skin (0.7). The median level of\n IFN-\u03b2<\/jats:italic>\n was significantly higher in warts than in non-lesional skin (20.7 vs 1.4) and both were significantly higher than that of control skin (1). The median level of SOCS3 was higher in nonlesional skin than in warts (1.05 vs 1), and both were significantly higher than that of control skin (0.1).\n <\/jats:p>\n <\/jats:sec>\n \n Limitations:<\/jats:title>\n Small sample size.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The expressions of\n IFN-\u03b1, IFN-\u03b2,<\/jats:italic>\n and\n SOCS3<\/jats:italic>\n genes were significantly elevated in the lesional and nonlesional skin of patients with warts than in the control skin.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/idoj.idoj_893_25","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:00:30Z","timestamp":1787756430000},"page":"668-674","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Gene Expression of Suppressor of Cytokine Signaling 3 (SOCS3), Interferons Alpha and Beta (IFN-\u03b1 and \u03b2) in Common Warts"],"prefix":"10.4103","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1686-1388","authenticated-orcid":false,"given":"Zeinab Abu El Baha","family":"Gouda","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9308-8731","authenticated-orcid":false,"given":"Hanan A.","family":"Assaf","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Saber Shafik","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, Faculty of Medicine, Sohag University, Sohag, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham Helal Abu","family":"Elhamd","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Sohag Mental Health and Addiction Treatment Hospital, Sohag, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0100-624X","authenticated-orcid":false,"given":"Mohammed","family":"Abu El-Hamd","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"R1-20260902","doi-asserted-by":"crossref","first-page":"e15935","DOI":"10.1111\/dth.15935","article-title":"Intralesional combined furosemide and digoxin in cutaneous warts treatment: A randomized controlled clinical trial","volume":"35","author":"Lofty","year":"2022","journal-title":"Dermatol 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