{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:24:15Z","timestamp":1787840655540,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Vulvar neoplasia is on the rise and patients often present to dermatologists with lesions of varying morphology associated with pruritus, burning sensation, or pain. Early diagnosis results in an early treatment and improved quality of life. Differentiating vulvar neoplasia and intraepithelial malignancies from benign and inflammatory conditions is imperative. Histopathology and immunohistochemistry (IHC) are helpful. Herein, we report eight women who presented with varying features. Five of them had predisposing factors- four had lichen sclerosus, and one was human immunodeficiency virus (HIV) positive. All women were diagnosed and treated promptly. Vulvar malignancies encompass both invasive vulvar squamous cell carcinoma (SCC) and its precursors, as well as other less common forms like melanoma, basal cell carcinoma, and extramammary Paget\u2019s disease. Vulvar SCC contributes to 80%\u201390% of vulvar malignancies. It\u2019s precursor lesions, vulvar intraepithelial neoplasia (VIN), are now classified as differentiated VIN (dVIN), low-grade squamous intraepithelial neoplasias (LSIL), and high grade squamous intraepithelial neoplasias (HSIL). VIN are of varying morphology and are diagnosed by histopathology and IHC. Dermoscopy of VIN is still evolving. Herein, we also describe the dermoscopic features of lesions encountered. Treatment is resection, wherever possible.<\/jats:p>","DOI":"10.4103\/idoj.idoj_911_24","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T07:00:26Z","timestamp":1756450826000},"page":"773-777","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Varying Faces of Vulvar Neoplasia"],"prefix":"10.4103","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0850-3038","authenticated-orcid":false,"given":"Kavitha","family":"Athota","sequence":"first","affiliation":[{"name":"Dr. Paruchuri Rajaram Memorial Skin and Laser Centre, Kothapet, Guntur, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2410-5208","authenticated-orcid":false,"given":"Smitha S.","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9397-2169","authenticated-orcid":false,"given":"Niranjana","family":"Gopinathan","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"issue":"(Suppl 1)","key":"R1-20250830","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/ijgo.13881","article-title":"Cancer of the vulva:2021 update","volume":"155","author":"Olawaiye","year":"2021","journal-title":"Int J Gynaecol Obstet"},{"key":"R2-20250830","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/s41379-021-00942-3","article-title":"Molecular landscape of vulvovaginal squamous cell carcinoma:New insights into molecular mechanisms of HPV-associated and HPV-independent squamous cell carcinoma","volume":"35","author":"Salama","year":"2022","journal-title":"Mod Pathol"},{"key":"R3-20250830","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.pathol.2016.02.015","article-title":"Squamous precursor lesions of the vulva:Current classification and diagnostic challenges","volume":"48","author":"Hoang","year":"2016","journal-title":"Pathology"},{"key":"R4-20250830","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1002\/ijc.33055","article-title":"Geographic and temporal variations in the incidence of vulvar and vaginal cancers","volume":"147","author":"Bray","year":"2020","journal-title":"Int J Cancer"},{"key":"R6-20250830","doi-asserted-by":"crossref","first-page":"49","DOI":"10.46405\/ejms.v3i2.381","article-title":"Prevalence of vulva carcinoma at BP Koirala Memorial Cancer Hospital, Nepal:A hospital based retrospective study","volume":"3","author":"Rana","year":"2021","journal-title":"Europasian J Med Sci"},{"key":"R7-20250830","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1365-2133.2010.10043.x","article-title":"Features of pigmented vulval lesions on dermoscopy","volume":"164","author":"Ronger-Savle","year":"2011","journal-title":"Br J Dermatol"},{"key":"R8-20250830","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/bjd.14796","article-title":"Dermoscopic findings of vulvar intraepithelial neoplasia:A series of four cases","volume":"176","author":"Barisani","year":"2017","journal-title":"Br J Dermatol"},{"key":"R9-20250830","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3727\/096504020X16076861118243","article-title":"Targeted therapeutic approaches in vulvar squamous cell cancer (VSCC):Case series and review of the literature","volume":"28","author":"Woelber","year":"2021","journal-title":"Oncol Res"},{"key":"R10-20250830","doi-asserted-by":"crossref","first-page":"e2200197","DOI":"10.1200\/GO.22.00197","article-title":"The unmet needs in the management of vulvar cancer and a review of Indian literature","volume":"8","author":"Kaur","year":"2022","journal-title":"JCO Glob Oncol"}],"container-title":["Indian Dermatology Online Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.idoj_911_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:35Z","timestamp":1787837195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/idoj.idoj_911_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/idoj.idoj_911_24","relation":{},"ISSN":["2229-5178","2249-5673"],"issn-type":[{"value":"2229-5178","type":"print"},{"value":"2249-5673","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"2024-09-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}