{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:54:31Z","timestamp":1789170871395,"version":"build-2803163510"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"\n Background and Aims:<\/jats:title>\n Postextubation airway complications are more common in paediatric patients than in adults. Intravenous lignocaine effectively prevents extubation response; however, data on using intracuff lignocaine in microcuff endotracheal tubes is scarce. The primary aim of this study was to compare the incidence of postextubation cough between intracuff lignocaine and intracuff air in the paediatric population during tracheal extubation.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n This randomised controlled study was conducted in 120 paediatric patients aged 1 month to 12 years who were scheduled to undergo surgeries under general anaesthesia. They were randomised to Group C (intracuff air) and Group L (intracuff 2% lignocaine). After administering general anaesthesia, the airway was secured with an age-appropriate microcuff endotracheal tube. According to groups, the cuff was inflated with air or lignocaine to achieve a cuff pressure of 10 cm H\n 2<\/jats:sub>\n O. Incidences of cough, desaturation, laryngospasm, apnoea and haemodynamic changes were recorded after tracheal extubation. Categorical variables were compared using the Chi-square or Fisher\u2019s exact test, and continuous variables were compared using the Student\u2019s\n t<\/jats:italic>\n -test or Mann\u2013Whitney U test. Intergroup differences between the variables were analysed by a two-way repeated measure analysis of variance.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The incidence of postextubation cough was significantly higher in Group C [17 (28.3%) (confidence interval {CI} = 17.4\u201341.4)] when compared to Group L [8 (13.3%) (CI = 5.9\u201324.6)], with\n P<\/jats:italic>\n = 0.043. One patient in Group C had laryngospasm compared to none in Group L. In Group C, there was also a significant increase in heart rate at all time points (1\u20135 min after extubation) from the baseline, and this increase was also significantly higher when compared to Group L (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The incidence of postextubation cough was significantly lower with intracuff lignocaine compared to that with intracuff air in paediatric patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ija.ija_1013_23","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T06:00:42Z","timestamp":1712901642000},"page":"486-491","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of endotracheal tube cuff lignocaine in the prevention of postextubation cough in children undergoing elective surgeries \u2013 A randomised controlled trial"],"prefix":"10.4103","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0698-5747","authenticated-orcid":false,"given":"M. B.","family":"Kavyashree","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-7932","authenticated-orcid":false,"given":"Pankaj","family":"Kundra","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7177-2962","authenticated-orcid":false,"given":"Stalin","family":"Vinayagam","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"R1-20260504","doi-asserted-by":"crossref","first-page":"210","DOI":"10.4103\/ija.IJA_948_19","article-title":"A descriptive survey of tracheal extubation practices among Indian anaesthesiologists","volume":"65","author":"Thakore","year":"2021","journal-title":"Indian J Anaesth"},{"key":"R2-20260504","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bjae.2021.10.003","article-title":"Extubation of children in the operating theatre","volume":"22","author":"Egbuta","year":"2022","journal-title":"BJA Educ"},{"key":"R3-20260504","doi-asserted-by":"crossref","first-page":"e07737","DOI":"10.1016\/j.heliyon.2021.e07737","article-title":"Lidocaine versus propofol administration on the attenuation of hemodynamic responses during extubation in the adult elective surgical patient: A prospective cohort","volume":"7","author":"Nigussie","year":"2021","journal-title":"Heliyon"},{"key":"R4-20260504","doi-asserted-by":"crossref","first-page":"763","DOI":"10.4103\/ija.IJA_391_19","article-title":"Postoperative anaesthetic concerns in children: Postoperative pain, emergence delirium and postoperative nausea and vomiting","volume":"63","author":"Mehrotra","year":"2019","journal-title":"Indian J Anaesth"},{"key":"R5-20260504","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF03012520","article-title":"In vitro diffusion of lidocaine across endotracheal tube cuffs","volume":"46","author":"Huang","year":"1999","journal-title":"Can J Anesth"},{"key":"R6-20260504","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1213\/01.ANE.0000097185.70171.89","article-title":"The incidence of laryngospasm with a \u201cno touch\u201d extubation technique after tonsillectomy and adenoidectomy","volume":"98","author":"Tsui","year":"2004","journal-title":"Anesth Analg"},{"key":"R7-20260504","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/anae.13764","article-title":"The effects of tracheal tube cuffs filled with air, saline or alkalinised lidocaine on hemodynamic changes and laryngotracheal morbidity in children: A randomised, controlled trial","volume":"72","author":"Soares","year":"2017","journal-title":"Anesthesia"},{"key":"R8-20260504","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1213\/00000539-200007000-00038","article-title":"The effects of intracuff lidocaine on endotracheal-tube-induced emergence phenomena after general anesthesia","volume":"91","author":"Fagan","year":"2000","journal-title":"Anesth Analg"},{"key":"R9-20260504","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF03018969","article-title":"Lidocaine added to a tracheostomy tube cuff reduces tube discomfort","volume":"47","author":"Hirota","year":"2000","journal-title":"Can J Anaesth"},{"key":"R10-20260504","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1213\/00000539-199008000-00008","article-title":"Fundamental properties of local anesthetics. 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